IE44428B1 - New derivatives of pleuromutilin and compositions containig same - Google Patents
New derivatives of pleuromutilin and compositions containig sameInfo
- Publication number
- IE44428B1 IE44428B1 IE1943/76A IE194376A IE44428B1 IE 44428 B1 IE44428 B1 IE 44428B1 IE 1943/76 A IE1943/76 A IE 1943/76A IE 194376 A IE194376 A IE 194376A IE 44428 B1 IE44428 B1 IE 44428B1
- Authority
- IE
- Ireland
- Prior art keywords
- mutilin
- mercaptoacetoxy
- diethylaminoethyl
- neutral fumarate
- deoxy
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical class C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 84
- 230000007935 neutral effect Effects 0.000 claims abstract description 48
- STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 claims abstract description 41
- OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229960002771 retapamulin Drugs 0.000 claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 58
- -1 2-diethylaminoethyl Chemical group 0.000 claims description 24
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- 239000001530 fumaric acid Substances 0.000 description 17
- ZRZNJUXESFHSIO-BKUNHTPHSA-N 3de4a80mz1 Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-BKUNHTPHSA-N 0.000 description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 description 9
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61808775A | 1975-09-30 | 1975-09-30 | |
| US05/709,983 US4086359A (en) | 1975-09-30 | 1976-07-30 | Derivatives of pleuromutilin and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44428L IE44428L (en) | 1977-03-30 |
| IE44428B1 true IE44428B1 (en) | 1981-12-02 |
Family
ID=27088148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1943/76A IE44428B1 (en) | 1975-09-30 | 1976-08-31 | New derivatives of pleuromutilin and compositions containig same |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS6029383B2 (enrdf_load_stackoverflow) |
| AT (1) | AT350835B (enrdf_load_stackoverflow) |
| CA (1) | CA1077056A (enrdf_load_stackoverflow) |
| CH (1) | CH595339A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2643672C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2326186A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1547437A (enrdf_load_stackoverflow) |
| IE (1) | IE44428B1 (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2526019A1 (fr) * | 1982-04-28 | 1983-11-04 | Sandoz Sa | Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments |
-
1976
- 1976-08-31 CA CA260,231A patent/CA1077056A/en not_active Expired
- 1976-08-31 IE IE1943/76A patent/IE44428B1/en not_active IP Right Cessation
- 1976-09-23 GB GB39543/76A patent/GB1547437A/en not_active Expired
- 1976-09-28 DE DE2643672A patent/DE2643672C2/de not_active Expired
- 1976-09-29 AT AT722976A patent/AT350835B/de not_active IP Right Cessation
- 1976-09-29 CH CH1230476A patent/CH595339A5/xx not_active IP Right Cessation
- 1976-09-30 JP JP51118409A patent/JPS6029383B2/ja not_active Expired
- 1976-09-30 FR FR7629398A patent/FR2326186A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH595339A5 (enrdf_load_stackoverflow) | 1978-02-15 |
| DE2643672A1 (de) | 1977-04-07 |
| ATA722976A (de) | 1978-11-15 |
| AT350835B (de) | 1979-06-25 |
| IE44428L (en) | 1977-03-30 |
| DE2643672C2 (de) | 1986-07-24 |
| JPS6029383B2 (ja) | 1985-07-10 |
| JPS5244221A (en) | 1977-04-07 |
| FR2326186A1 (fr) | 1977-04-29 |
| CA1077056A (en) | 1980-05-06 |
| FR2326186B1 (enrdf_load_stackoverflow) | 1978-11-17 |
| GB1547437A (en) | 1979-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |