IE41671L - Amidated immune globulins. - Google Patents
Amidated immune globulins.Info
- Publication number
- IE41671L IE41671L IE751944A IE194475A IE41671L IE 41671 L IE41671 L IE 41671L IE 751944 A IE751944 A IE 751944A IE 194475 A IE194475 A IE 194475A IE 41671 L IE41671 L IE 41671L
- Authority
- IE
- Ireland
- Prior art keywords
- immunoglobulins
- amidated
- immune globulins
- gb1517026a
- sulphydryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Amidated immunoglobulins suitable for intravenous administration are prepared by reacting immunoglobulins with a molar excess of a primary monoamine and a carbodiimide or its salt in weakly acidic to neutral aqueous solution. As a result of the amidation, the undesired complement binding by the immunoglobulins is prevented or at least substantially decreased without the antibody action of the immunoglobulins being impaired. The process can be applied to reduced immunoglobulins, in which at least one disulphide bond has been converted to two sulphydryl bonds.
[GB1517026A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2442655A DE2442655C3 (en) | 1974-09-06 | 1974-09-06 | Amidated immunoglobulins and their use for intravenous administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41671L true IE41671L (en) | 1976-03-06 |
| IE41671B1 IE41671B1 (en) | 1980-02-27 |
Family
ID=5925019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1944/75A IE41671B1 (en) | 1974-09-06 | 1975-09-05 | Modified imune globulins and process for their preparation |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5161623A (en) |
| AR (1) | AR212909A1 (en) |
| AT (1) | AT342763B (en) |
| AU (1) | AU499871B2 (en) |
| BE (1) | BE833186A (en) |
| BR (1) | BR7505721A (en) |
| CA (1) | CA1056819A (en) |
| CH (1) | CH615194A5 (en) |
| DE (1) | DE2442655C3 (en) |
| DK (1) | DK399175A (en) |
| EG (1) | EG11813A (en) |
| FR (1) | FR2283695A1 (en) |
| GB (1) | GB1517026A (en) |
| IE (1) | IE41671B1 (en) |
| IL (1) | IL48049A (en) |
| IT (1) | IT1048485B (en) |
| LU (1) | LU73328A1 (en) |
| NL (1) | NL7510289A (en) |
| NZ (1) | NZ178580A (en) |
| SE (1) | SE403704B (en) |
| ZA (1) | ZA755687B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004697A (en) * | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3704282A (en) * | 1971-04-09 | 1972-11-28 | Sidney Spector | Catecholamine antigens and antibodies specific therefor |
-
1974
- 1974-09-06 DE DE2442655A patent/DE2442655C3/en not_active Expired
-
1975
- 1975-09-01 NL NL7510289A patent/NL7510289A/en not_active Application Discontinuation
- 1975-09-04 CH CH1147275A patent/CH615194A5/en not_active IP Right Cessation
- 1975-09-04 GB GB36451/75A patent/GB1517026A/en not_active Expired
- 1975-09-04 LU LU73328A patent/LU73328A1/xx unknown
- 1975-09-04 IT IT26918/75A patent/IT1048485B/en active
- 1975-09-04 AU AU84536/75A patent/AU499871B2/en not_active Expired
- 1975-09-04 IL IL48049A patent/IL48049A/en unknown
- 1975-09-04 NZ NZ178580A patent/NZ178580A/en unknown
- 1975-09-05 IE IE1944/75A patent/IE41671B1/en unknown
- 1975-09-05 FR FR7527354A patent/FR2283695A1/en active Granted
- 1975-09-05 CA CA235,134A patent/CA1056819A/en not_active Expired
- 1975-09-05 BR BR7505721*A patent/BR7505721A/en unknown
- 1975-09-05 DK DK399175A patent/DK399175A/en not_active Application Discontinuation
- 1975-09-05 SE SE7509898A patent/SE403704B/en unknown
- 1975-09-05 AT AT689475A patent/AT342763B/en not_active IP Right Cessation
- 1975-09-05 ZA ZA00755687A patent/ZA755687B/en unknown
- 1975-09-06 JP JP50107581A patent/JPS5161623A/ja active Pending
- 1975-09-06 EG EG521/75A patent/EG11813A/en active
- 1975-09-08 BE BE159842A patent/BE833186A/en unknown
- 1975-09-14 AR AR260263A patent/AR212909A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2283695B1 (en) | 1978-09-22 |
| DE2442655A1 (en) | 1976-03-18 |
| IL48049A (en) | 1978-08-31 |
| SE7509898L (en) | 1976-03-08 |
| ZA755687B (en) | 1976-08-25 |
| FR2283695A1 (en) | 1976-04-02 |
| CH615194A5 (en) | 1980-01-15 |
| DE2442655B2 (en) | 1979-02-01 |
| AR212909A1 (en) | 1978-11-15 |
| SE403704B (en) | 1978-09-04 |
| LU73328A1 (en) | 1977-05-11 |
| BE833186A (en) | 1976-03-08 |
| IT1048485B (en) | 1980-11-20 |
| DK399175A (en) | 1976-03-07 |
| NL7510289A (en) | 1976-03-09 |
| DE2442655C3 (en) | 1979-09-20 |
| AT342763B (en) | 1978-04-25 |
| JPS5161623A (en) | 1976-05-28 |
| NZ178580A (en) | 1978-03-06 |
| GB1517026A (en) | 1978-07-05 |
| CA1056819A (en) | 1979-06-19 |
| BR7505721A (en) | 1976-08-03 |
| AU8453675A (en) | 1977-03-10 |
| EG11813A (en) | 1978-09-30 |
| IE41671B1 (en) | 1980-02-27 |
| IL48049A0 (en) | 1975-11-25 |
| ATA689475A (en) | 1977-08-15 |
| AU499871B2 (en) | 1979-05-03 |
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