SE8003591L - IMMUNOGLOBULINDERIVAT - Google Patents
IMMUNOGLOBULINDERIVATInfo
- Publication number
- SE8003591L SE8003591L SE8003591A SE8003591A SE8003591L SE 8003591 L SE8003591 L SE 8003591L SE 8003591 A SE8003591 A SE 8003591A SE 8003591 A SE8003591 A SE 8003591A SE 8003591 L SE8003591 L SE 8003591L
- Authority
- SE
- Sweden
- Prior art keywords
- immunoglobulin
- ion
- contrast
- alkali metal
- side effects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Native immunoglobulin is treated, for the selective cleavage of the disulphide bonds between chains, with a sulphite ion in the presence, as oxidising agent, of a compound which is capable of forming a persulphate ion in water. In contrast to the use of oxidising agents which are generally known per se and which give agglutinated immunoglobulin derivatives of increased anticomplementary activity, the immunoglobulin derivatives obtained by this process have reduced anticomplementary activity, can be intravenously injected and are reconverted, within the body of the patient and without side effects, into the original immunoglobulin. By contrast with the known use of alkali metal tetrathionates, iodosobenzoic acid and alkali metal salts thereof, a copper(II) ion or molecular oxygen, the oxidising agents which can be used are industrially prepared, readily available and inexpensive compounds which lead, in a simple manner, to an end product of high purity which can be used without causing any unwanted side effects.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5971079A JPS55153724A (en) | 1979-05-17 | 1979-05-17 | Preparation of immunoglobulin derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8003591L true SE8003591L (en) | 1980-11-18 |
| SE435787B SE435787B (en) | 1984-10-22 |
Family
ID=13121030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8003591A SE435787B (en) | 1979-05-17 | 1980-05-13 | PROCEDURE FOR PREPARING IMMUNOGLOBULIN DERIVATIVES |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS55153724A (en) |
| CH (1) | CH644130A5 (en) |
| DE (1) | DE3018901C2 (en) |
| SE (1) | SE435787B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446233A (en) * | 1982-05-05 | 1984-05-01 | E. I. Du Pont De Nemours And Company | Homogeneous immunoassay using covalent hybrid antibodies |
| NZ215967A (en) * | 1985-05-01 | 1988-05-30 | Commw Serum Lab Commission | Composition of peptides of known weight for determining weight of unknown peptide |
| AU590754B2 (en) * | 1985-05-01 | 1989-11-16 | Commonwealth Serum Laboratories Commission | Novel molecular weight standards and methods of use thereof |
| JPH0346299Y2 (en) * | 1985-11-22 | 1991-09-30 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS511630A (en) * | 1974-06-24 | 1976-01-08 | Teijin Ltd | JOMYAKUCHUSHAYOMENEKIGUROBURINNO SEIZOHO |
-
1979
- 1979-05-17 JP JP5971079A patent/JPS55153724A/en active Granted
-
1980
- 1980-05-13 SE SE8003591A patent/SE435787B/en not_active IP Right Cessation
- 1980-05-14 CH CH379780A patent/CH644130A5/en not_active IP Right Cessation
- 1980-05-16 DE DE19803018901 patent/DE3018901C2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3018901A1 (en) | 1980-11-20 |
| CH644130A5 (en) | 1984-07-13 |
| DE3018901C2 (en) | 1982-04-22 |
| JPS55153724A (en) | 1980-11-29 |
| JPS62886B2 (en) | 1987-01-10 |
| SE435787B (en) | 1984-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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| NUG | Patent has lapsed |
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