IE40794B1 - Influenza vaccines - Google Patents

Influenza vaccines

Info

Publication number
IE40794B1
IE40794B1 IE59/75A IE5975A IE40794B1 IE 40794 B1 IE40794 B1 IE 40794B1 IE 59/75 A IE59/75 A IE 59/75A IE 5975 A IE5975 A IE 5975A IE 40794 B1 IE40794 B1 IE 40794B1
Authority
IE
Ireland
Prior art keywords
influenza
components
virus
type
cationic detergent
Prior art date
Application number
IE59/75A
Other versions
IE40794L (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE40794L publication Critical patent/IE40794L/en
Publication of IE40794B1 publication Critical patent/IE40794B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

1498261 Influenza vaccines SANDOZ Ltd 13 Jan 1975 [14 Jan 1974] 1290/75 Heading A5B The haemagglutinin and neuramuridase components are isolated from influenza virus by treating the virus in an aqueous medium with a cationic detergent to selectively solubilise such components, and separating the resulting solubilised such components from residual sub-viral particles. The virus concentrate may have a pH of from 6.5 to 8.5 and may inactivated with formaldehyde prior to the addition of the cationic detergent. After addition of the cationic detergent, the resulting mixture is preferably allowed to stand for 30 minutes to 16 hours at 4‹C to 37‹C. Influenza vaccines comprise a mixture of the haemagglutinin and neuramuridase components of an influenza virus, in the substantial absence of other components of the influenza viral particle in association with -an inertliquid diluent such as physiological saline optionally phosphate buffered. The vaccine may additionally comprise a preserving or inactivating agent such as formaldehyde and/or an immunological adjuvant such as aluminium hydroxide or aluminium phosphate. The influenza virus may be an influenza Type A, A 1 , A 2 or B virus, strain A2/Aichi/68, MRC-2 (recombination of Type A2/England/42/72), MRC-11 (recombination of Type A2/Port Chalmers/73), A/Pasteur/30C (Mutagrip), or B/Mass/67. [GB1498261A]
IE59/75A 1974-01-14 1975-01-13 Influenza vaccines IE40794B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH44774A CH589453A5 (en) 1974-01-14 1974-01-14

Publications (2)

Publication Number Publication Date
IE40794L IE40794L (en) 1975-07-14
IE40794B1 true IE40794B1 (en) 1979-08-15

Family

ID=4187233

Family Applications (1)

Application Number Title Priority Date Filing Date
IE59/75A IE40794B1 (en) 1974-01-14 1975-01-13 Influenza vaccines

Country Status (27)

Country Link
JP (2) JPS58407B2 (en)
AT (1) AT345449B (en)
AU (1) AU500250B2 (en)
BE (1) BE824372A (en)
CA (1) CA1049406A (en)
CH (1) CH589453A5 (en)
CS (1) CS191254B2 (en)
DD (1) DD116239A5 (en)
DE (1) DE2500785B2 (en)
DK (1) DK140003B (en)
ES (1) ES433759A1 (en)
FI (1) FI54053C (en)
FR (1) FR2257305B1 (en)
GB (1) GB1498261A (en)
HK (1) HK56380A (en)
HU (1) HU173920B (en)
IE (1) IE40794B1 (en)
IL (1) IL46426A (en)
MY (1) MY8100204A (en)
NL (1) NL166622C (en)
NO (1) NO143128C (en)
PH (1) PH14458A (en)
PL (1) PL93689B1 (en)
SE (1) SE427238B (en)
SU (1) SU616997A3 (en)
YU (1) YU41289B (en)
ZA (1) ZA75259B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2829089A1 (en) * 1977-07-13 1979-02-01 Sandoz Ag SUBUNIT VACCINE
JPH0688911B2 (en) * 1985-06-06 1994-11-09 国立予防衛生研究所長 Influenza vaccine and method for producing the same
TW570803B (en) * 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
EP0919243A1 (en) 1997-11-25 1999-06-02 Duphar International Research B.V Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant
DE19938767C2 (en) * 1999-08-16 2002-10-24 Tad Pharma Gmbh subunit vaccines
ES2359214T5 (en) * 2005-11-01 2014-10-08 Novartis Vaccines And Diagnostics Gmbh Viral vaccines derived from cells with reduced levels of residual cellular DNA by treatment with beta-propiolactone
SI2192917T1 (en) * 2007-08-28 2014-05-30 Baxter International Inc. Method for producing viral vaccines
EP3068791B1 (en) 2013-11-15 2020-07-29 Novartis AG Removal of residual cell culture impurities

Also Published As

Publication number Publication date
FR2257305B1 (en) 1982-03-19
DD116239A5 (en) 1975-11-12
ZA75259B (en) 1976-08-25
AU500250B2 (en) 1979-05-17
IE40794L (en) 1975-07-14
JPS50100224A (en) 1975-08-08
NO143128B (en) 1980-09-15
NL166622C (en) 1981-09-15
NL166622B (en) 1981-04-15
DK1475A (en) 1975-09-01
FI750014A (en) 1975-07-15
SU616997A3 (en) 1978-07-25
SE427238B (en) 1983-03-21
NO750031L (en) 1975-08-11
JPS58407B2 (en) 1983-01-06
ATA21475A (en) 1978-01-15
HU173920B (en) 1979-09-28
DE2500785A1 (en) 1975-07-31
DE2500785B2 (en) 1980-01-03
SE7500130L (en) 1975-07-15
ES433759A1 (en) 1977-02-16
BE824372A (en) 1975-07-14
AU7730575A (en) 1976-07-15
YU5875A (en) 1984-04-30
DK140003C (en) 1979-10-29
PH14458A (en) 1981-07-29
DE2500785C3 (en) 1980-09-11
FR2257305A1 (en) 1975-08-08
IL46426A0 (en) 1975-04-25
FI54053B (en) 1978-06-30
GB1498261A (en) 1978-01-18
JPS56127319A (en) 1981-10-06
HK56380A (en) 1980-10-16
DK140003B (en) 1979-06-05
CH589453A5 (en) 1977-07-15
CA1049406A (en) 1979-02-27
MY8100204A (en) 1981-12-31
NO143128C (en) 1980-12-29
IL46426A (en) 1978-01-31
FI54053C (en) 1978-10-10
JPS6035326B2 (en) 1985-08-14
CS191254B2 (en) 1979-06-29
NL7500301A (en) 1975-07-16
YU41289B (en) 1987-02-28
PL93689B1 (en) 1977-06-30
AT345449B (en) 1978-09-11

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