IE40657B1 - Unsymmetrically substituted 1,4-dioxane-2,5-diones - Google Patents
Unsymmetrically substituted 1,4-dioxane-2,5-dionesInfo
- Publication number
- IE40657B1 IE40657B1 IE2680/74A IE268074A IE40657B1 IE 40657 B1 IE40657 B1 IE 40657B1 IE 2680/74 A IE2680/74 A IE 2680/74A IE 268074 A IE268074 A IE 268074A IE 40657 B1 IE40657 B1 IE 40657B1
- Authority
- IE
- Ireland
- Prior art keywords
- diones
- dioxane
- alpha
- formula
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Dental Preparations (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
The 1,4-dioxane-2,5-diones conform to the formula <IMAGE> in which R1, R2, R3 and R4 are as defined in Claim 1. They are prepared by a1) reacting an alpha -halo-, alpha -(lower alkanoyl)oxy- or alpha -(lower alkyl)sulphonyloxyacetic acid which is appropriately substituted by R1 and R2 with an alpha -hydroxyacetic acid which is appropriately substituted by R3 and R4 in the presence of a strongly acidic catalyst, or a2) reacting monochloroacetic acid with L-lactide or poly-(D,L-lactic acid) in the presence of antimony trioxide, titanium dioxide or tetraisopropyl titanate, b) rendering the resultant product alkaline, and c) cyclising the product. The homopolymers and copolymers of the 1,4-dioxane-2,5-diones of the formula I are compatible with living human and mammal tissue, can be used surgically and are biodegradable to give tissue-compatible components which are absorbed by living tissues. At least 2% by weight of the 1,4-dioxane-2,5-diones are copolymerised with compounds of the formula <IMAGE> in which R5, R6, R7 and R8 are as defined in Claim 6, by heating in the presence of a catalyst, giving polymers which contain at least 2% by weight of copolymerised compounds of the formula I. The polymers can be used for the production of shaped surgical aids which can be absorbed by living tissue.
[GB1494781A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43536574A | 1974-01-21 | 1974-01-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40657L IE40657L (en) | 1975-07-21 |
| IE40657B1 true IE40657B1 (en) | 1979-07-18 |
Family
ID=23728099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2680/74A IE40657B1 (en) | 1974-01-21 | 1974-12-31 | Unsymmetrically substituted 1,4-dioxane-2,5-diones |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS50101367A (en) |
| AR (1) | AR205454A1 (en) |
| AT (1) | AT339902B (en) |
| BE (1) | BE824535A (en) |
| CA (1) | CA1052046A (en) |
| CH (1) | CH616417A5 (en) |
| CS (1) | CS196258B2 (en) |
| DD (1) | DD119259A5 (en) |
| DE (1) | DE2501448A1 (en) |
| DK (1) | DK15275A (en) |
| FR (1) | FR2279745A1 (en) |
| GB (1) | GB1494781A (en) |
| HU (1) | HU173692B (en) |
| IE (1) | IE40657B1 (en) |
| IN (1) | IN141151B (en) |
| IT (1) | IT1044114B (en) |
| NL (1) | NL7500689A (en) |
| PH (1) | PH12680A (en) |
| PL (1) | PL101805B1 (en) |
| RO (1) | RO70688A (en) |
| SE (1) | SE7500594L (en) |
| ZA (1) | ZA7538B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56157422A (en) * | 1980-05-07 | 1981-12-04 | Mitsui Toatsu Chem Inc | Acetylated polyglycolic acid and preparation thereof |
| EP0264926B1 (en) * | 1986-10-24 | 1992-04-08 | Boehringer Ingelheim Kg | Process for the preparation and purification of thermally instable compounds |
| EP0318567B1 (en) * | 1987-06-16 | 1992-03-18 | Boehringer Ingelheim Kg | ''meso-lactide'' and process for manufacturing it |
| EP0339882A1 (en) * | 1988-04-27 | 1989-11-02 | MITSUI TOATSU CHEMICALS, Inc. | Process for the production of lactide |
| DE4321355A1 (en) * | 1993-06-26 | 1995-01-05 | Basf Ag | Polylactide with long chain branches |
| DE4440095A1 (en) * | 1994-11-10 | 1996-05-15 | Braun B Surgical Gmbh | Surgical sutures, their use in surgery, and methods of making them |
| EP0789080B1 (en) | 1996-02-08 | 2002-01-16 | Gesellschaft für ökologische Technologie und Systemanalyse e.V. | Process for the preparation of organic aminium lactates and their use in the preparation of dilactide |
| FR2873371B1 (en) * | 2004-07-26 | 2008-07-04 | Sod Conseils Rech Applic | NEW METHOD OF SYNTHESIS OF 2,5 DIOXANE 1,4 DIONES |
| US20090138041A1 (en) * | 2006-05-15 | 2009-05-28 | Stopek Joshua B | Halogenated Cyclic Lactones and Polymers Made Therefrom |
| BR112014003981A2 (en) | 2011-08-23 | 2017-03-07 | Endo Pharmaceuticals Inc | pyrimido-pyridazinone compounds and their use |
| AU2013216828B2 (en) * | 2012-02-09 | 2017-01-12 | Novus International Inc. | Functionalized polymer compositions |
-
1974
- 1974-12-24 CA CA216,765A patent/CA1052046A/en not_active Expired
- 1974-12-31 IE IE2680/74A patent/IE40657B1/en unknown
-
1975
- 1975-01-01 AR AR257269A patent/AR205454A1/en active
- 1975-01-02 ZA ZA00750038A patent/ZA7538B/en unknown
- 1975-01-03 IN IN23/CAL/1975A patent/IN141151B/en unknown
- 1975-01-09 GB GB1003/75A patent/GB1494781A/en not_active Expired
- 1975-01-10 PH PH16698A patent/PH12680A/en unknown
- 1975-01-13 RO RO7581101A patent/RO70688A/en unknown
- 1975-01-14 CS CS75253A patent/CS196258B2/en unknown
- 1975-01-15 DE DE19752501448 patent/DE2501448A1/en not_active Withdrawn
- 1975-01-20 BE BE152494A patent/BE824535A/en unknown
- 1975-01-20 IT IT47760/75A patent/IT1044114B/en active
- 1975-01-20 SE SE7500594A patent/SE7500594L/xx unknown
- 1975-01-20 DD DD183736A patent/DD119259A5/xx unknown
- 1975-01-20 PL PL1975177442A patent/PL101805B1/en unknown
- 1975-01-20 CH CH61375A patent/CH616417A5/en not_active IP Right Cessation
- 1975-01-20 AT AT39075A patent/AT339902B/en not_active IP Right Cessation
- 1975-01-20 DK DK15275*BA patent/DK15275A/da not_active Application Discontinuation
- 1975-01-20 HU HU75AE436A patent/HU173692B/en unknown
- 1975-01-21 NL NL7500689A patent/NL7500689A/en not_active Application Discontinuation
- 1975-01-21 JP JP50008413A patent/JPS50101367A/ja active Pending
- 1975-01-21 FR FR7501823A patent/FR2279745A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE2501448A1 (en) | 1975-07-24 |
| PH12680A (en) | 1979-07-18 |
| AU7708575A (en) | 1976-07-08 |
| ZA7538B (en) | 1976-01-28 |
| JPS50101367A (en) | 1975-08-11 |
| NL7500689A (en) | 1975-07-23 |
| IT1044114B (en) | 1980-03-20 |
| AT339902B (en) | 1977-11-10 |
| SE7500594L (en) | 1975-07-22 |
| GB1494781A (en) | 1977-12-14 |
| DK15275A (en) | 1975-09-15 |
| ATA39075A (en) | 1977-03-15 |
| PL101805B1 (en) | 1979-02-28 |
| RO70688A (en) | 1982-05-10 |
| CA1052046A (en) | 1979-04-03 |
| BE824535A (en) | 1975-07-22 |
| DD119259A5 (en) | 1976-04-12 |
| AR205454A1 (en) | 1976-05-07 |
| CS196258B2 (en) | 1980-03-31 |
| HU173692B (en) | 1979-07-28 |
| FR2279745B1 (en) | 1978-02-24 |
| IN141151B (en) | 1977-01-22 |
| IE40657L (en) | 1975-07-21 |
| CH616417A5 (en) | 1980-03-31 |
| FR2279745A1 (en) | 1976-02-20 |
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