IE40657L - 1,4-dioxane - 2, 5 - diones , polymers thereof and¹surgical sutures produced from such polymers - Google Patents

1,4-dioxane - 2, 5 - diones , polymers thereof and¹surgical sutures produced from such polymers

Info

Publication number
IE40657L
IE40657L IE742680A IE268074A IE40657L IE 40657 L IE40657 L IE 40657L IE 742680 A IE742680 A IE 742680A IE 268074 A IE268074 A IE 268074A IE 40657 L IE40657 L IE 40657L
Authority
IE
Ireland
Prior art keywords
diones
dioxane
polymers
alpha
formula
Prior art date
Application number
IE742680A
Other versions
IE40657B1 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IE40657L publication Critical patent/IE40657L/en
Publication of IE40657B1 publication Critical patent/IE40657B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/121,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • A61L17/105Polyesters not covered by A61L17/12
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Dental Preparations (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The 1,4-dioxane-2,5-diones conform to the formula <IMAGE> in which R1, R2, R3 and R4 are as defined in Claim 1. They are prepared by a1) reacting an alpha -halo-, alpha -(lower alkanoyl)oxy- or alpha -(lower alkyl)sulphonyloxyacetic acid which is appropriately substituted by R1 and R2 with an alpha -hydroxyacetic acid which is appropriately substituted by R3 and R4 in the presence of a strongly acidic catalyst, or a2) reacting monochloroacetic acid with L-lactide or poly-(D,L-lactic acid) in the presence of antimony trioxide, titanium dioxide or tetraisopropyl titanate, b) rendering the resultant product alkaline, and c) cyclising the product. The homopolymers and copolymers of the 1,4-dioxane-2,5-diones of the formula I are compatible with living human and mammal tissue, can be used surgically and are biodegradable to give tissue-compatible components which are absorbed by living tissues. At least 2% by weight of the 1,4-dioxane-2,5-diones are copolymerised with compounds of the formula <IMAGE> in which R5, R6, R7 and R8 are as defined in Claim 6, by heating in the presence of a catalyst, giving polymers which contain at least 2% by weight of copolymerised compounds of the formula I. The polymers can be used for the production of shaped surgical aids which can be absorbed by living tissue. [GB1494781A]
IE2680/74A 1974-01-21 1974-12-31 Unsymmetrically substituted 1,4-dioxane-2,5-diones IE40657B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43536574A 1974-01-21 1974-01-21

Publications (2)

Publication Number Publication Date
IE40657L true IE40657L (en) 1975-07-21
IE40657B1 IE40657B1 (en) 1979-07-18

Family

ID=23728099

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2680/74A IE40657B1 (en) 1974-01-21 1974-12-31 Unsymmetrically substituted 1,4-dioxane-2,5-diones

Country Status (22)

Country Link
JP (1) JPS50101367A (en)
AR (1) AR205454A1 (en)
AT (1) AT339902B (en)
BE (1) BE824535A (en)
CA (1) CA1052046A (en)
CH (1) CH616417A5 (en)
CS (1) CS196258B2 (en)
DD (1) DD119259A5 (en)
DE (1) DE2501448A1 (en)
DK (1) DK15275A (en)
FR (1) FR2279745A1 (en)
GB (1) GB1494781A (en)
HU (1) HU173692B (en)
IE (1) IE40657B1 (en)
IN (1) IN141151B (en)
IT (1) IT1044114B (en)
NL (1) NL7500689A (en)
PH (1) PH12680A (en)
PL (1) PL101805B1 (en)
RO (1) RO70688A (en)
SE (1) SE7500594L (en)
ZA (1) ZA7538B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56157422A (en) * 1980-05-07 1981-12-04 Mitsui Toatsu Chem Inc Acetylated polyglycolic acid and preparation thereof
DE3778111D1 (en) * 1986-10-24 1992-05-14 Boehringer Ingelheim Kg METHOD FOR PRODUCING AND CLEANING THERMOLABILE COMPOUNDS.
JPH02500593A (en) * 1987-06-16 1990-03-01 ベーリンガー インゲルハイム コマンディットゲゼルシャフト Meso-lactide and its manufacturing method
EP0339882A1 (en) * 1988-04-27 1989-11-02 MITSUI TOATSU CHEMICALS, Inc. Process for the production of lactide
DE4321355A1 (en) * 1993-06-26 1995-01-05 Basf Ag Polylactide with long chain branches
DE4440095A1 (en) * 1994-11-10 1996-05-15 Braun B Surgical Gmbh Surgical sutures, their use in surgery, and methods of making them
ATE212062T1 (en) 1996-02-08 2002-02-15 Oekologische Technologie Und S METHOD FOR PRODUCING ORGANIC AMINIUM LACTATES AND THE USE THEREOF FOR PRODUCING DILACTIDE
FR2873371B1 (en) * 2004-07-26 2008-07-04 Sod Conseils Rech Applic NEW METHOD OF SYNTHESIS OF 2,5 DIOXANE 1,4 DIONES
WO2007133783A1 (en) * 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Halogenated cyclic lactones and polymers made therefrom
HUE065564T2 (en) 2011-08-23 2024-06-28 Libertas Bio Inc Pyrimido- pyridazinone compounds and use thereof
WO2013119959A1 (en) * 2012-02-09 2013-08-15 Novus International Inc. Heteroatom containing cyclic dimers

Also Published As

Publication number Publication date
NL7500689A (en) 1975-07-23
CA1052046A (en) 1979-04-03
IT1044114B (en) 1980-03-20
ATA39075A (en) 1977-03-15
CH616417A5 (en) 1980-03-31
HU173692B (en) 1979-07-28
AT339902B (en) 1977-11-10
DK15275A (en) 1975-09-15
AU7708575A (en) 1976-07-08
IE40657B1 (en) 1979-07-18
FR2279745B1 (en) 1978-02-24
BE824535A (en) 1975-07-22
ZA7538B (en) 1976-01-28
PL101805B1 (en) 1979-02-28
DD119259A5 (en) 1976-04-12
SE7500594L (en) 1975-07-22
FR2279745A1 (en) 1976-02-20
GB1494781A (en) 1977-12-14
AR205454A1 (en) 1976-05-07
JPS50101367A (en) 1975-08-11
RO70688A (en) 1982-05-10
PH12680A (en) 1979-07-18
DE2501448A1 (en) 1975-07-24
IN141151B (en) 1977-01-22
CS196258B2 (en) 1980-03-31

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