IE38544B1 - Benzo-or naphtho dipyran-di(n-tetrazolyl)-carboxamide derivatives methods for their production and compositions containing them - Google Patents
Benzo-or naphtho dipyran-di(n-tetrazolyl)-carboxamide derivatives methods for their production and compositions containing themInfo
- Publication number
- IE38544B1 IE38544B1 IE2129/73A IE212973A IE38544B1 IE 38544 B1 IE38544 B1 IE 38544B1 IE 2129/73 A IE2129/73 A IE 2129/73A IE 212973 A IE212973 A IE 212973A IE 38544 B1 IE38544 B1 IE 38544B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- hydrogen
- pairs
- further substituted
- attached
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1449810 Benzo- or naphtho-dipyran-dicarboxamide derivatives FISONS Ltd 16 Nov 1973 [5 Dec 1972 17 Aug 1973 (2)] 55997/72 39046/73 and 39047/73 Heading C2C [Also in Division A5] Novel compounds I and their salts in which two chains of Formula XX (in which each pair of R 9 and R 10 may be different and each R 9 and R 10 are selected from hydrogen, C 1-6 alkyl C 2-6 alkenyl, phenyl, phenyl C 1-6 alkyl, C 2-6 alkanoyl or C 2-6 alkoxycarbonyl) are attached to two pairs of ortho positions on a benzene or naphthalene nucleus which may be further substituted are prepared by (1) replacing a group R 12 with hydrogen (by using a hydrogen halide, catalytic hydrogenation, sodium in liquid ammonia, basic conditions or reactive diamination) in a compound in which two chains of Formula XXd are attached respectively to two pairs of ortho positions on a benzene or naphthalene nucleus which may be further substituted or removing both groups R 12 from a corresponding compound in which R 10 = R 12 to form a compound I (R 10 = H) (2) cyclizing a compound in which two chains of Formula XXe are attached to two pairs of ortho positions of an optionally further substituted benzene or naphthalene nucleus (3) reacting a compound in which two chains are attached to two pairs of ortho positions of an optionally further substituted benzene or naphthelene nucleus or an acid halide, ester or mixed anhydride thereof with a compound of Formula IV to form a compound I (R 9 =H when R 10 =H) (4) cyclizing a compound in which two pairs of groups -OH and (in which Y is -OH or NL 1 L 2 in which L 1 and L 2 are hydrogen phenyl or C 1-6 alkyl or together form a saturated or unsaturated 4 or 5 membered alkylene chain) are attached to two pairs of ortho positions on an optionally further substituted benzene or naphthalene nucleus or (5) selectively dehydrogenating a compound in which two chains of Formula XXf are attached to two pairs of ortho positions on an optionally further substituted benzene or naphthalene nucleus and, if desired, converting a compound I to a salt thereof compounds I prepared are those of Formulµ In, Io and Ip in which R 9 is hydrogen or methyl, R 10 is hydrogen, methyl, allyl carbethoxy, acetyl or benzyl and Pa and Qa are selected from hydrogen, C 1-5 alkyl, allyl, hydroxyl, chlorine, bromine, methoxy, ethoxy, allyloxy benzyloxy, nitro and ethoxymethyl, salts of a compound In (in which Qa, R 9 and R 10 are hydrogen and Pa is methoxy) with lithium, sodium, potassium, calcium, diethanolamine, tri-ethanolamine, tris-hydroxy methyl-methylamine, morpholine and N-methyl glucamine are also prepared. Compounds I inhibit antigen-antibody reactions.
[GB1449810A]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5599772 | 1972-12-05 | ||
GB3904673*[A GB1449810A (en) | 1972-12-05 | 1973-08-17 | Benzo-or naphtho-dipyran-di-n-tetrazolyl- -carboxamide derivative methods for their production and compositions containing them |
GB3904773 | 1973-08-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE38544L IE38544L (en) | 1974-06-05 |
IE38544B1 true IE38544B1 (en) | 1978-04-12 |
Family
ID=27259543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE2129/73A IE38544B1 (en) | 1972-12-05 | 1973-11-23 | Benzo-or naphtho dipyran-di(n-tetrazolyl)-carboxamide derivatives methods for their production and compositions containing them |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS4993366A (en) |
AR (1) | AR210310A1 (en) |
CH (1) | CH593277A5 (en) |
DD (1) | DD109387A5 (en) |
DE (1) | DE2360331A1 (en) |
ES (1) | ES421132A1 (en) |
FR (1) | FR2208670B1 (en) |
GB (1) | GB1449810A (en) |
IE (1) | IE38544B1 (en) |
IL (1) | IL43709A (en) |
LU (1) | LU68934A1 (en) |
MW (1) | MW6873A1 (en) |
NL (1) | NL7316658A (en) |
NO (1) | NO141517C (en) |
PL (1) | PL102530B1 (en) |
SE (1) | SE409205B (en) |
SU (1) | SU553934A3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792547A (en) * | 1985-12-26 | 1988-12-20 | Hokuriku Pharmaceutical Co., Ltd. | Pyrazine-2-carboxamide derivatives useful in treating allergic disease |
JP4340545B2 (en) * | 2002-04-23 | 2009-10-07 | ロレアル | Cosmetic composition for promoting hair growth and / or preventing or delaying hair removal |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1354477A (en) * | 1970-04-02 | 1974-06-05 | Fisons Ltd | Benzo di and tri-pyrones |
GB1321879A (en) * | 1970-12-30 | 1973-07-04 | Fisons Ltd | Di-carboxybenzopyrano-benzopyrans |
BE789822A (en) * | 1971-10-08 | 1973-04-06 | Allen & Hanburys Ltd | NEW HETEROCYCLIC COMPOUNDS |
-
1973
- 1973-08-17 GB GB3904673*[A patent/GB1449810A/en not_active Expired
- 1973-11-23 IE IE2129/73A patent/IE38544B1/en unknown
- 1973-11-27 IL IL43709A patent/IL43709A/en unknown
- 1973-11-27 MW MW68/73*UA patent/MW6873A1/en unknown
- 1973-12-03 FR FR7342955A patent/FR2208670B1/fr not_active Expired
- 1973-12-04 PL PL1973167040A patent/PL102530B1/en unknown
- 1973-12-04 ES ES421132A patent/ES421132A1/en not_active Expired
- 1973-12-04 SU SU1977568A patent/SU553934A3/en active
- 1973-12-04 CH CH1694773A patent/CH593277A5/xx not_active IP Right Cessation
- 1973-12-04 SE SE7316373A patent/SE409205B/en unknown
- 1973-12-04 DE DE2360331A patent/DE2360331A1/en not_active Withdrawn
- 1973-12-04 LU LU68934A patent/LU68934A1/xx unknown
- 1973-12-04 NO NO4629/73A patent/NO141517C/en unknown
- 1973-12-05 JP JP48135465A patent/JPS4993366A/ja active Pending
- 1973-12-05 NL NL7316658A patent/NL7316658A/xx not_active Application Discontinuation
- 1973-12-05 DD DD175118A patent/DD109387A5/xx unknown
-
1976
- 1976-12-04 AR AR251356A patent/AR210310A1/en active
Also Published As
Publication number | Publication date |
---|---|
CH593277A5 (en) | 1977-11-30 |
JPS4993366A (en) | 1974-09-05 |
NO141517C (en) | 1980-03-26 |
PL102530B1 (en) | 1979-04-30 |
SU553934A3 (en) | 1977-04-05 |
ES421132A1 (en) | 1976-04-16 |
IE38544L (en) | 1974-06-05 |
IL43709A (en) | 1977-04-29 |
MW6873A1 (en) | 1974-07-10 |
AU6305073A (en) | 1975-05-29 |
IL43709A0 (en) | 1974-03-14 |
AR210310A1 (en) | 1977-07-29 |
DE2360331A1 (en) | 1974-06-06 |
GB1449810A (en) | 1976-09-15 |
FR2208670A1 (en) | 1974-06-28 |
DD109387A5 (en) | 1974-11-05 |
LU68934A1 (en) | 1974-07-05 |
NO141517B (en) | 1979-12-17 |
SE409205B (en) | 1979-08-06 |
NL7316658A (en) | 1974-06-07 |
FR2208670B1 (en) | 1978-01-13 |
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