IE37655L - Derivatives of 1-phenoxy-3-aminopropane-2-ol. - Google Patents
Derivatives of 1-phenoxy-3-aminopropane-2-ol.Info
- Publication number
- IE37655L IE37655L IE730805A IE80573A IE37655L IE 37655 L IE37655 L IE 37655L IE 730805 A IE730805 A IE 730805A IE 80573 A IE80573 A IE 80573A IE 37655 L IE37655 L IE 37655L
- Authority
- IE
- Ireland
- Prior art keywords
- phenoxy
- alkyl
- new derivatives
- propane
- amino
- Prior art date
Links
- JZEHWMUIAKALDN-UHFFFAOYSA-N 1-amino-3-phenoxypropan-2-ol Chemical class NCC(O)COC1=CC=CC=C1 JZEHWMUIAKALDN-UHFFFAOYSA-N 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention relates to pharmacologically valuable new derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production. The new derivatives of 1-phenoxy-3-amino-propane-2-ol are suitable for the treatment and prophylaxis of diseases of the heart. Some possess pronounced beta -adrenalytic or anti-arythmic properties. These new derivatives have the structural formula WHEREIN X signifies AND THE PHENYL NUCLEUS I may be mono-, di- or trisubstituted by alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, phenyl, halogen or the radical -NR1R2, in which R1 stands for alkyl or acyl and R2 for hydrogen or alkyl, together with their aldehyde condensation products and their acid addition salts.
[US3940406A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU65414 | 1972-05-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37655L true IE37655L (en) | 1973-11-24 |
| IE37655B1 IE37655B1 (en) | 1977-09-14 |
Family
ID=19727058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE805/73A IE37655B1 (en) | 1972-05-24 | 1973-05-21 | Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3940406A (en) |
| JP (4) | JPS4948675A (en) |
| AR (4) | AR199904A1 (en) |
| AT (4) | AT326660B (en) |
| BE (1) | BE800005A (en) |
| BG (3) | BG21851A3 (en) |
| CA (1) | CA1015357A (en) |
| CH (4) | CH596180A5 (en) |
| CS (4) | CS183692B2 (en) |
| DD (1) | DD106835A5 (en) |
| DE (1) | DE2323354A1 (en) |
| ES (4) | ES415046A1 (en) |
| FR (1) | FR2185411B1 (en) |
| GB (1) | GB1409959A (en) |
| HU (1) | HU165663B (en) |
| IE (1) | IE37655B1 (en) |
| IL (1) | IL42333A (en) |
| LU (1) | LU65414A1 (en) |
| NL (1) | NL7306691A (en) |
| PH (3) | PH9827A (en) |
| PL (1) | PL91588B1 (en) |
| RO (2) | RO66268A (en) |
| SE (1) | SE399425B (en) |
| SU (4) | SU489309A3 (en) |
| ZA (1) | ZA733513B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066768A (en) * | 1973-12-27 | 1978-01-03 | Cassella Farbwerke Mainkur Aktiengesellschaft | Derivatives of 1-phenoxy-3-amino-propan-2-ol |
| US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| CH591448A5 (en) * | 1974-05-14 | 1977-09-15 | Ciba Geigy Ag | |
| JPS528043A (en) * | 1975-07-10 | 1977-01-21 | Toagosei Chem Ind Co Ltd | Adhesive |
| US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
| US4060601A (en) * | 1976-06-15 | 1977-11-29 | Merck & Co., Inc. | Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines |
| JPH0774714B2 (en) * | 1986-11-18 | 1995-08-09 | 中野冷機株式会社 | Open showcase temperature controller |
| JP2858389B2 (en) * | 1994-02-21 | 1999-02-17 | カシオ計算機株式会社 | Liquid crystal display device and manufacturing method thereof |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| US7244751B2 (en) * | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1047927A (en) * | 1964-03-09 | 1966-11-09 | Ici Ltd | Alkanolamine derivatives |
| US3261829A (en) * | 1964-08-12 | 1966-07-19 | Searle & Co | Spiro(steroidal-6,3'-1-pyrazolines) and process |
| US3679693A (en) * | 1970-09-15 | 1972-07-25 | Smith Kline French Lab | N-pyridylalkyl-{62 -alkoxy-{62 -trifluoromethyl-phenalkylamines |
| CH578532A5 (en) * | 1971-08-03 | 1976-08-13 | Cassella Farbwerke Mainkur Ag | |
| BE787057A (en) * | 1971-08-03 | 1973-02-01 | Cassella Farbwerke Mainkur Ag | DERIVATIVES OF PHENOXY-1 AMINO-3 PROPANOL-2 AND MEDICINES CONTAINING IT |
-
1972
- 1972-05-24 LU LU65414A patent/LU65414A1/xx unknown
-
1973
- 1973-05-09 DE DE2323354A patent/DE2323354A1/en active Pending
- 1973-05-14 NL NL7306691A patent/NL7306691A/xx not_active Application Discontinuation
- 1973-05-16 HU HUCA346A patent/HU165663B/hu unknown
- 1973-05-21 US US05/362,567 patent/US3940406A/en not_active Expired - Lifetime
- 1973-05-21 SU SU1923622A patent/SU489309A3/en active
- 1973-05-21 IE IE805/73A patent/IE37655B1/en unknown
- 1973-05-21 SU SU7301923620A patent/SU582755A3/en active
- 1973-05-21 SU SU1923621A patent/SU563120A3/en active
- 1973-05-22 DD DD170987A patent/DD106835A5/xx unknown
- 1973-05-22 BG BG024936A patent/BG21851A3/en unknown
- 1973-05-22 IL IL42333A patent/IL42333A/en unknown
- 1973-05-22 BG BG023691A patent/BG20782A3/en unknown
- 1973-05-22 JP JP48056387A patent/JPS4948675A/ja active Pending
- 1973-05-22 JP JP48056386A patent/JPS4941380A/ja active Pending
- 1973-05-22 BG BG24934A patent/BG22072A3/xx unknown
- 1973-05-23 ES ES415046A patent/ES415046A1/en not_active Expired
- 1973-05-23 AR AR248189A patent/AR199904A1/en active
- 1973-05-23 ES ES415044A patent/ES415044A1/en not_active Expired
- 1973-05-23 AR AR248187A patent/AR199903A1/en active
- 1973-05-23 CA CA172,038A patent/CA1015357A/en not_active Expired
- 1973-05-23 AT AT450373A patent/AT326660B/en not_active IP Right Cessation
- 1973-05-23 RO RO7300077378A patent/RO66268A/en unknown
- 1973-05-23 CH CH737873A patent/CH596180A5/xx not_active IP Right Cessation
- 1973-05-23 CS CS7300003712A patent/CS183692B2/en unknown
- 1973-05-23 JP JP48056903A patent/JPS4948677A/ja active Pending
- 1973-05-23 CS CS7300003713A patent/CS183701B2/en unknown
- 1973-05-23 RO RO7374886A patent/RO64607A/en unknown
- 1973-05-23 GB GB2458273A patent/GB1409959A/en not_active Expired
- 1973-05-23 AT AT450073A patent/AT326657B/en not_active IP Right Cessation
- 1973-05-23 JP JP48056904A patent/JPS4948678A/ja active Pending
- 1973-05-23 CS CS7300003714A patent/CS181241B2/en unknown
- 1973-05-23 PH PH14648A patent/PH9827A/en unknown
- 1973-05-23 CH CH737773A patent/CH581622A5/xx not_active IP Right Cessation
- 1973-05-23 AT AT450173A patent/AT326658B/en not_active IP Right Cessation
- 1973-05-23 SU SU1922038A patent/SU493958A3/en active
- 1973-05-23 AR AR248190A patent/AR199905A1/en active
- 1973-05-23 ZA ZA733513A patent/ZA733513B/en unknown
- 1973-05-23 SE SE7307242A patent/SE399425B/en unknown
- 1973-05-23 CS CS7300003715A patent/CS183702B2/en unknown
- 1973-05-23 CH CH737673A patent/CH581621A5/xx not_active IP Right Cessation
- 1973-05-23 ES ES415045A patent/ES415045A1/en not_active Expired
- 1973-05-23 PL PL1973162780A patent/PL91588B1/pl unknown
- 1973-05-23 ES ES415047A patent/ES415047A1/en not_active Expired
- 1973-05-23 CH CH737573A patent/CH581620A5/xx not_active IP Right Cessation
- 1973-05-23 AT AT450273A patent/AT326659B/en not_active IP Right Cessation
- 1973-05-24 FR FR7318866A patent/FR2185411B1/fr not_active Expired
- 1973-05-24 BE BE131502A patent/BE800005A/en unknown
-
1974
- 1974-03-08 PH PH15602*UA patent/PH9369A/en unknown
- 1974-03-08 PH PH15601*A patent/PH9508A/en unknown
- 1974-05-23 AR AR248188A patent/AR200869A1/en active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE37655L (en) | Derivatives of 1-phenoxy-3-aminopropane-2-ol. | |
| RO78465A (en) | PROCESS FOR THE PREPARATION OF 1,2-BENZISOXAZOLCARBOXYLIC ACID DERIVATIVES | |
| ES405276A1 (en) | Pyrimidinylphrazolone derivative and process of preparing the same | |
| GB1188154A (en) | New Pyridine Derivatives and process for their preparation | |
| IE37717B1 (en) | N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture | |
| ZA711800B (en) | Process for the production of new aryloxy-and arylthioalkanoic acids,of their salts and functional derivatives | |
| GB1363658A (en) | Benzobicycloalkane compounds | |
| CH550182A (en) | PROCESS FOR THE PREPARATION OF BASIC SUBSTITUTED DERIVATIVES OF 2,4- (1H, 3H) -CHINAZOLINDIONE. | |
| ES408023A1 (en) | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES DECEFALESPERINE AND PENICILLIN. | |
| SE429963B (en) | ADDITION PRODUCTS OF ETHYLENOXIDE, PROPYLENOXIDE OR GLYCID WITH COMPOUNDS RECOVERED BY THE TRANSACTION OF EPSILON-CAPROLACTAM WITH ALKANDIAMINES, PROCEDURES FOR THE PRODUCTION OF THEREOF AND USE AS ANTIMICRO ... | |
| IE39049B1 (en) | New 1,4-dihydroquinoline derivatives their production and their medicinal use | |
| BE770256A (en) | PROCESS FOR THE PREPARATION OF PHOSPHORIC POLYCONDENSATION PRODUCTS, THE PRODUCTS OBTAINED, AS WELL AS THEIR USE AS FLAMING AGENTS | |
| ES427198A1 (en) | Novel cyclopentane derivatives | |
| GB599013A (en) | Improvements in or relating to the production of aromatic amine n-pentosides | |
| AT203504B (en) | Process for the preparation of new derivatives of piperazine | |
| BE808971A (en) | PROCESS FOR PREPARING NEW 1,4-DISUBSTITUDE DERIVATIVES OF PIPERAZINE AS WELL AS THE PRODUCTS OBTAINED | |
| HU168381B (en) | Process for production of derivatives of 8,12-diizoprostanic acid | |
| ATA555874A (en) | PROCESS FOR THE PREPARATION OF THE NEW 6- (N-METHYL-AMINDOCARBONYLOXYMETHYL) -2-PYRIDYLMETHYLESTER OF 2- (P-CHLOROPHENOXY) -2,2-DIMETHYL ACID ACID AND ITS ACID ADDITION SALTS | |
| GB870575A (en) | Benzothiadiazines and the production thereof | |
| BE791947A (en) | NEW FORMAMIDIN DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR APPLICATION AS ACARICIDES | |
| BE788591R (en) | PROCESS FOR PREPARING PHOSPHORIC POLYCONDENSATION PRODUCTS, THE PRODUCTS OBTAINED, AS WELL AS THEIR USE AS AGENTS | |
| CH551980A (en) | PROCESS FOR THE PREPARATION OF BASIC SUBSTITUTED DERIVATIVES OF 2,4- (1H, 3H) -CHINAZOLINDIONE. | |
| GB1284051A (en) | Process for the preparation of 3,4-dihydroisoquinoline derivatives | |
| AT340436B (en) | PROCESS FOR THE PRODUCTION OF NEW DERIVATIVES OF 1-PHENOXY-3-AMINO-PROPAN-2-OL, THEIR ALDEHYDE CONDENSATION PRODUCTS AND ACID ADDITION SALTS AND THEIR STEREO AND OPTICAL ISOMERS | |
| GB715212A (en) | Novel derivatives of pyridoxine and the manufacture thereof |