IE37641B1 - 5-(and 7-)benzoylindolin-2-ones - Google Patents
5-(and 7-)benzoylindolin-2-onesInfo
- Publication number
- IE37641B1 IE37641B1 IE785/73A IE78573A IE37641B1 IE 37641 B1 IE37641 B1 IE 37641B1 IE 785/73 A IE785/73 A IE 785/73A IE 78573 A IE78573 A IE 78573A IE 37641 B1 IE37641 B1 IE 37641B1
- Authority
- IE
- Ireland
- Prior art keywords
- ones
- indolin
- prepared
- substituted indolinones
- benzoylindolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B45/00—Complex metal compounds of azo dyes
- C09B45/02—Preparation from dyes containing in o-position a hydroxy group and in o'-position hydroxy, alkoxy, carboxyl, amino or keto groups
- C09B45/24—Disazo or polyazo compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B35/00—Disazo and polyazo dyes of the type A<-D->B prepared by diazotising and coupling
- C09B35/02—Disazo dyes
- C09B35/039—Disazo dyes characterised by the tetrazo component
- C09B35/08—Disazo dyes characterised by the tetrazo component the tetrazo component being a derivative of biphenyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring (AREA)
Abstract
1432577 Indolin-2-ones A H ROBINS CO Inc 16 May 1973 [17 May 1972] 23374/73 Heading C2C The invention comprises compounds of formula wherein the benzoyl group is in the 5- or 7-position of the indoline ring, and R, R<SP>1</SP> are each H or C 1 -C 6 alkyl, or R<SP>1</SP> is C 1 -C 6 alkoxy, halogen, NO 2 or CF 3 . The 5-substituted indolinones are prepared by reacting an indolin-2-one with R<SP>1</SP>C 6 H 4 COCl; the 7- substituted indolinones are prepared by cyclizing a 2-acetamido-3-benzoylphenylacetic acid or an ethyl ester thereof. Therapeutic compositions which are preferably administered orally comprise compounds of the above formula, which prevent the inflammatory response to pleural irritation.
[GB1432577A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25428472A | 1972-05-17 | 1972-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37641L IE37641L (en) | 1973-11-17 |
| IE37641B1 true IE37641B1 (en) | 1977-09-14 |
Family
ID=22963675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE785/73A IE37641B1 (en) | 1972-05-17 | 1973-05-17 | 5-(and 7-)benzoylindolin-2-ones |
Country Status (17)
| Country | Link |
|---|---|
| JP (2) | JPS5139222B2 (en) |
| AT (1) | AT323731B (en) |
| BE (2) | BE799612A (en) |
| CA (1) | CA1000715A (en) |
| CH (1) | CH577469A5 (en) |
| DE (2) | DE943075C (en) |
| DK (1) | DK139677B (en) |
| ES (1) | ES414802A1 (en) |
| FI (1) | FI56377C (en) |
| FR (1) | FR2184933B1 (en) |
| GB (1) | GB1432577A (en) |
| IE (1) | IE37641B1 (en) |
| IL (1) | IL42216A (en) |
| NL (2) | NL183187C (en) |
| PH (1) | PH9815A (en) |
| SE (1) | SE393980B (en) |
| ZA (1) | ZA733151B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5371842U (en) * | 1976-11-17 | 1978-06-15 | ||
| US4221716A (en) * | 1979-02-16 | 1980-09-09 | A. H. Robins Company, Inc. | Intermediate and process for the preparation of 7-acylindolin-2-ones |
| DE3300522A1 (en) * | 1982-01-21 | 1983-07-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 3,3-DIALKYL AND 3,3-ALKYLENE INDOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
| JPH0349563Y2 (en) * | 1985-08-31 | 1991-10-23 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH232507A (en) * | 1941-02-18 | 1944-05-31 | Chem Ind Basel | Process for the preparation of a disazo dye. |
-
0
- BE BE524637D patent/BE524637A/xx unknown
- NL NL90149D patent/NL90149C/xx active
-
1953
- 1953-11-25 DE DEC8502A patent/DE943075C/en not_active Expired
-
1973
- 1973-05-07 FI FI1452/73A patent/FI56377C/en active
- 1973-05-08 IL IL42216A patent/IL42216A/en unknown
- 1973-05-09 ZA ZA733151A patent/ZA733151B/en unknown
- 1973-05-11 PH PH14608A patent/PH9815A/en unknown
- 1973-05-11 DK DK263073AA patent/DK139677B/en unknown
- 1973-05-15 CH CH689973A patent/CH577469A5/xx not_active IP Right Cessation
- 1973-05-15 SE SE7306853A patent/SE393980B/en unknown
- 1973-05-16 NL NLAANVRAGE7306832,A patent/NL183187C/en not_active IP Right Cessation
- 1973-05-16 GB GB2337473A patent/GB1432577A/en not_active Expired
- 1973-05-16 DE DE2324767A patent/DE2324767C2/en not_active Expired
- 1973-05-16 BE BE131181A patent/BE799612A/en not_active IP Right Cessation
- 1973-05-16 AT AT429973A patent/AT323731B/en not_active IP Right Cessation
- 1973-05-16 FR FR7317755A patent/FR2184933B1/fr not_active Expired
- 1973-05-16 CA CA171,512A patent/CA1000715A/en not_active Expired
- 1973-05-16 ES ES414802A patent/ES414802A1/en not_active Expired
- 1973-05-17 IE IE785/73A patent/IE37641B1/en unknown
- 1973-05-17 JP JP48054204A patent/JPS5139222B2/ja not_active Expired
-
1976
- 1976-05-13 JP JP51054786A patent/JPS5910660B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE799612A (en) | 1973-09-17 |
| IL42216A0 (en) | 1973-07-30 |
| NL7306832A (en) | 1973-11-20 |
| JPS4941366A (en) | 1974-04-18 |
| FI56377B (en) | 1979-09-28 |
| DK139677C (en) | 1979-09-10 |
| JPS5217466A (en) | 1977-02-09 |
| SE393980B (en) | 1977-05-31 |
| FI56377C (en) | 1980-01-10 |
| JPS5139222B2 (en) | 1976-10-26 |
| ES414802A1 (en) | 1976-02-01 |
| AU5584773A (en) | 1974-11-21 |
| NL183187B (en) | 1988-03-16 |
| PH9815A (en) | 1976-03-26 |
| DK139677B (en) | 1979-03-26 |
| DE943075C (en) | 1956-05-09 |
| AT323731B (en) | 1975-07-25 |
| FR2184933B1 (en) | 1976-05-14 |
| GB1432577A (en) | 1976-04-22 |
| JPS5910660B2 (en) | 1984-03-10 |
| NL183187C (en) | 1988-08-16 |
| FR2184933A1 (en) | 1973-12-28 |
| CH577469A5 (en) | 1976-07-15 |
| CA1000715A (en) | 1976-11-30 |
| IE37641L (en) | 1973-11-17 |
| DE2324767C2 (en) | 1985-07-25 |
| DE2324767A1 (en) | 1973-11-29 |
| BE524637A (en) | |
| IL42216A (en) | 1976-08-31 |
| NL90149C (en) | |
| ZA733151B (en) | 1974-04-24 |
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