IE36939L - Imidazole derivatives of rifamycin - Google Patents
Imidazole derivatives of rifamycinInfo
- Publication number
- IE36939L IE36939L IE721666A IE166672A IE36939L IE 36939 L IE36939 L IE 36939L IE 721666 A IE721666 A IE 721666A IE 166672 A IE166672 A IE 166672A IE 36939 L IE36939 L IE 36939L
- Authority
- IE
- Ireland
- Prior art keywords
- rifamycin
- alkyl
- imidazole derivatives
- desacetyl
- mono
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1388880 3-Imidazole derivatives of rifamycin SV GRUPPO LEPETIT SpA 28 Dec 1972 [19 Jan 1972] 59832/72 Heading C2C Novel 3-imidazole derivatives of rifamycin SV having the general Formula (I) and the corresponding 25-desacetyl and 16, 17, 18, 19, 28, 29-hexahydro derivatives, wherein R is hydrogen, C 1-6 alkyl, phenyl or phenyl- C 1-6 alkyl; and R 1 and R 2 together represent a carbocyclic residue forming with the double bond of the adjacent imidazol moiety a benzene ring; a mono- or poly-substituted benzene ring wherein the substituents are selected from C 1-6 alkyl, C 1-6 alkoxy, halo, carbalkoxy, carboxy, sulpho, sulphamoyl, nitro, trifluoromethyl, carbamyl, mono- and di-C 1-6 alkylcarbamyl and methylenedioxy; or a substituted or unsubstituted polynuclear aromatic radical composed of 2 or 3 fused rings each of 5-6 carbon atoms, are prepared by reacting 3-formylrifamycin SV or a 25-desacetyl or 16, 17, 18, 19, 28, 29-hexahydro derivative thereof, with an orthodiamine of formula wherein R, R 1 and R 2 are as defined above, and then oxidizing the product with air, a cupric salt, mercuric oxide, manganese dioxide, isoamyl nitrite, potassium ferricyanide or lead tetraacetate, and if the rifamycin moiety in the obtained compound is in the quinone form, reducing it to the corresponding hydroquinone with aqueous ascorbic acid. The compounds (I) have antibacterial, antiviral and anti-cancer activity and may be admixed with a pharmaceutical carrier to provide pharmaceutical compositions having such activity.
[GB1388880A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1952572 | 1972-01-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36939L true IE36939L (en) | 1973-07-19 |
| IE36939B1 IE36939B1 (en) | 1977-03-30 |
Family
ID=11158763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1666/72A IE36939B1 (en) | 1972-01-19 | 1972-11-30 | Imidazole derivatives of rifamycin |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS518959B2 (en) |
| AR (1) | AR193313A1 (en) |
| AT (1) | AT320855B (en) |
| AU (1) | AU466810B2 (en) |
| BE (1) | BE794298A (en) |
| CA (1) | CA991636A (en) |
| CH (1) | CH564554A5 (en) |
| DD (1) | DD103236A5 (en) |
| DE (1) | DE2301766C3 (en) |
| DK (1) | DK135995B (en) |
| ES (1) | ES410755A1 (en) |
| FR (1) | FR2181676B1 (en) |
| GB (1) | GB1388880A (en) |
| HU (1) | HU165387B (en) |
| IE (1) | IE36939B1 (en) |
| IL (1) | IL41017A (en) |
| LU (1) | LU66851A1 (en) |
| NL (1) | NL159388B (en) |
| RO (1) | RO62774A (en) |
| SE (1) | SE383152B (en) |
| SU (1) | SU444372A3 (en) |
| ZA (1) | ZA728306B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5480960U (en) * | 1977-11-18 | 1979-06-08 | ||
| US4447432A (en) * | 1981-11-17 | 1984-05-08 | Farmitalia Carlo Erba S.P.A. | Azino rifamycins |
| US7247634B2 (en) | 2004-01-13 | 2007-07-24 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives effective against drug-resistant microbes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA930734A (en) * | 1969-08-11 | 1973-07-24 | Bickel Hans | Antibiotically active rifamycin compounds and processes for their manufacture |
-
0
- BE BE794298D patent/BE794298A/en unknown
-
1972
- 1972-11-23 ZA ZA728306A patent/ZA728306B/en unknown
- 1972-11-30 IE IE1666/72A patent/IE36939B1/en unknown
- 1972-12-06 IL IL41017A patent/IL41017A/en unknown
- 1972-12-28 GB GB5983272A patent/GB1388880A/en not_active Expired
-
1973
- 1973-01-15 CH CH52873A patent/CH564554A5/xx not_active IP Right Cessation
- 1973-01-15 AU AU51099/73A patent/AU466810B2/en not_active Expired
- 1973-01-15 DE DE2301766A patent/DE2301766C3/en not_active Expired
- 1973-01-16 NL NL7300610.A patent/NL159388B/en unknown
- 1973-01-16 DD DD168274A patent/DD103236A5/xx unknown
- 1973-01-16 AR AR246143A patent/AR193313A1/en active
- 1973-01-17 AT AT37173A patent/AT320855B/en not_active IP Right Cessation
- 1973-01-17 SU SU1872137A patent/SU444372A3/en active
- 1973-01-17 LU LU66851A patent/LU66851A1/xx unknown
- 1973-01-18 FR FR7301784A patent/FR2181676B1/fr not_active Expired
- 1973-01-18 CA CA161,561A patent/CA991636A/en not_active Expired
- 1973-01-18 HU HULE675A patent/HU165387B/hu unknown
- 1973-01-18 DK DK28173AA patent/DK135995B/en unknown
- 1973-01-18 SE SE7300711A patent/SE383152B/en unknown
- 1973-01-18 JP JP48008230A patent/JPS518959B2/ja not_active Expired
- 1973-01-18 ES ES410755A patent/ES410755A1/en not_active Expired
- 1973-01-19 RO RO7300073551A patent/RO62774A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO62774A (en) | 1978-02-15 |
| ZA728306B (en) | 1973-07-25 |
| AU466810B2 (en) | 1975-11-13 |
| CH564554A5 (en) | 1975-07-31 |
| DD103236A5 (en) | 1974-01-12 |
| FR2181676A1 (en) | 1973-12-07 |
| IL41017A (en) | 1976-06-30 |
| JPS4880600A (en) | 1973-10-29 |
| AT320855B (en) | 1975-03-10 |
| DK135995B (en) | 1977-07-25 |
| CA991636A (en) | 1976-06-22 |
| DE2301766B2 (en) | 1980-02-28 |
| AR193313A1 (en) | 1973-04-11 |
| DE2301766A1 (en) | 1973-07-26 |
| NL7300610A (en) | 1973-07-23 |
| ES410755A1 (en) | 1976-01-01 |
| JPS518959B2 (en) | 1976-03-22 |
| FR2181676B1 (en) | 1976-05-14 |
| HU165387B (en) | 1974-08-28 |
| BE794298A (en) | 1973-05-16 |
| DE2301766C3 (en) | 1980-11-20 |
| SE383152B (en) | 1976-03-01 |
| SU444372A3 (en) | 1974-09-25 |
| IE36939B1 (en) | 1977-03-30 |
| AU5109973A (en) | 1974-07-18 |
| NL159388B (en) | 1979-02-15 |
| IL41017A0 (en) | 1973-02-28 |
| GB1388880A (en) | 1975-03-26 |
| LU66851A1 (en) | 1973-03-19 |
| DK135995C (en) | 1978-01-23 |
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