IE36485L - Benzothiophenes. - Google Patents
Benzothiophenes.Info
- Publication number
- IE36485L IE36485L IE720790A IE79072A IE36485L IE 36485 L IE36485 L IE 36485L IE 720790 A IE720790 A IE 720790A IE 79072 A IE79072 A IE 79072A IE 36485 L IE36485 L IE 36485L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- reaction
- compound
- june
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1357212 Benzothiapine derivatives LABAZ 16 June 1972 [25 June 1971] 30032/71 Heading C2C Novel compounds of Formula I and the pharmaceutically acceptable acid addition salts thereof, for example the oxalate or hydrochloride, wherein R represents hydrogen or a branched or straight-chain alkyl group containing from 1 to 4 carbon atoms, R<SP>1</SP> represents hydrogen or methyl, X and X 1 , which are identical, each represent an atom of chlorine, bromine or iodine, Am represents a dimethylamino, diethylamino, di - n - propylamino, di - n - butylamino, pyrrolidino, piperidino or perhydroazepino group, and n is an integer in the range of from I to 5 inclusive are prepared by reaction of HAm with a compound of Formula IV or in the case where n is 1 or 2 by reaction of a compound II with (Z is halogen or tosyloxy). Intermediates of Formula IV above are prepared by reaction of with an intermediate of Formula II above obtained by the demethylation of the corresponding methyl ether starting material followed by halogenation. Pharmaceutical compositions in conventional forms for oral or rectal administration comprise an above novel compound and a carrier or diluent. The compositions are of use in the treatment of heart conditions.
[GB1357212A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3003271A GB1357212A (en) | 1971-06-25 | 1971-06-25 | Benzothiophene derivatives and process for preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36485L true IE36485L (en) | 1972-12-25 |
| IE36485B1 IE36485B1 (en) | 1976-11-10 |
Family
ID=10301169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE790/72A IE36485B1 (en) | 1971-06-25 | 1972-06-07 | Benzothiophene derivatives and process for preparing same |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS4844248A (en) |
| AT (1) | AT312597B (en) |
| AU (1) | AU462617B2 (en) |
| BE (1) | BE784260A (en) |
| CA (1) | CA959492A (en) |
| CH (2) | CH549042A (en) |
| DE (1) | DE2230669A1 (en) |
| ES (1) | ES404252A1 (en) |
| FI (1) | FI54477C (en) |
| FR (1) | FR2143250B1 (en) |
| GB (1) | GB1357212A (en) |
| HU (1) | HU166255B (en) |
| IE (1) | IE36485B1 (en) |
| NL (1) | NL7208703A (en) |
| OA (1) | OA04117A (en) |
| SE (1) | SE385482B (en) |
| SU (2) | SU453844A3 (en) |
| ZA (1) | ZA723868B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947470A (en) * | 1974-06-20 | 1976-03-30 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| JPS5973579A (en) * | 1982-10-19 | 1984-04-25 | Kotobuki Seiyaku Kk | Benzofuran or benzothiophene derivative, diuretic agent containing said compound as active constituent and preparation thereof |
| NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
| CA2145614A1 (en) * | 1994-03-31 | 1995-10-01 | Jeffrey A. Dodge | Intermediates and processes for preparing benzothiophene compounds |
| CA2231013A1 (en) * | 1997-04-30 | 1998-10-30 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals |
-
1971
- 1971-06-25 GB GB3003271A patent/GB1357212A/en not_active Expired
-
1972
- 1972-06-01 BE BE784260A patent/BE784260A/en unknown
- 1972-06-05 FI FI1578/72A patent/FI54477C/en active
- 1972-06-06 ZA ZA723868A patent/ZA723868B/en unknown
- 1972-06-07 IE IE790/72A patent/IE36485B1/en unknown
- 1972-06-13 AU AU43338/72A patent/AU462617B2/en not_active Expired
- 1972-06-13 HU HULA799A patent/HU166255B/hu unknown
- 1972-06-21 CH CH930272A patent/CH549042A/en not_active IP Right Cessation
- 1972-06-21 SE SE7208187A patent/SE385482B/en unknown
- 1972-06-21 CH CH1795273A patent/CH548409A/en not_active IP Right Cessation
- 1972-06-22 FR FR7222480A patent/FR2143250B1/fr not_active Expired
- 1972-06-23 SU SU1800666A patent/SU453844A3/ru active
- 1972-06-23 CA CA145,600A patent/CA959492A/en not_active Expired
- 1972-06-23 NL NL7208703A patent/NL7208703A/xx not_active Application Discontinuation
- 1972-06-23 DE DE19722230669 patent/DE2230669A1/en active Pending
- 1972-06-23 SU SU721959344A patent/SU486510A3/en active
- 1972-06-24 JP JP47063621A patent/JPS4844248A/ja active Pending
- 1972-06-24 ES ES404252A patent/ES404252A1/en not_active Expired
- 1972-06-26 AT AT545972A patent/AT312597B/en not_active IP Right Cessation
- 1972-06-26 OA OA54619A patent/OA04117A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4333872A (en) | 1973-12-20 |
| SU486510A3 (en) | 1975-09-30 |
| FI54477C (en) | 1978-12-11 |
| AT312597B (en) | 1974-01-10 |
| FR2143250A1 (en) | 1973-02-02 |
| FR2143250B1 (en) | 1975-06-20 |
| NL7208703A (en) | 1972-12-28 |
| AU462617B2 (en) | 1975-06-10 |
| JPS4844248A (en) | 1973-06-26 |
| IE36485B1 (en) | 1976-11-10 |
| CA959492A (en) | 1974-12-17 |
| DE2230669A1 (en) | 1972-12-28 |
| CH549042A (en) | 1974-05-15 |
| HU166255B (en) | 1975-02-28 |
| ZA723868B (en) | 1973-03-28 |
| OA04117A (en) | 1979-11-30 |
| BE784260A (en) | 1972-12-01 |
| ES404252A1 (en) | 1975-06-01 |
| GB1357212A (en) | 1974-06-19 |
| SE385482B (en) | 1976-07-05 |
| SU453844A3 (en) | 1974-12-15 |
| FI54477B (en) | 1978-08-31 |
| CH548409A (en) | 1974-04-30 |
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