IE36485B1 - Benzothiophene derivatives and process for preparing same - Google Patents

Benzothiophene derivatives and process for preparing same

Info

Publication number
IE36485B1
IE36485B1 IE790/72A IE79072A IE36485B1 IE 36485 B1 IE36485 B1 IE 36485B1 IE 790/72 A IE790/72 A IE 790/72A IE 79072 A IE79072 A IE 79072A IE 36485 B1 IE36485 B1 IE 36485B1
Authority
IE
Ireland
Prior art keywords
formula
reaction
compound
june
prepared
Prior art date
Application number
IE790/72A
Other versions
IE36485L (en
Original Assignee
Labaz Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz Corp filed Critical Labaz Corp
Publication of IE36485L publication Critical patent/IE36485L/en
Publication of IE36485B1 publication Critical patent/IE36485B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Abstract

1357212 Benzothiapine derivatives LABAZ 16 June 1972 [25 June 1971] 30032/71 Heading C2C Novel compounds of Formula I and the pharmaceutically acceptable acid addition salts thereof, for example the oxalate or hydrochloride, wherein R represents hydrogen or a branched or straight-chain alkyl group containing from 1 to 4 carbon atoms, R<SP>1</SP> represents hydrogen or methyl, X and X 1 , which are identical, each represent an atom of chlorine, bromine or iodine, Am represents a dimethylamino, diethylamino, di - n - propylamino, di - n - butylamino, pyrrolidino, piperidino or perhydroazepino group, and n is an integer in the range of from I to 5 inclusive are prepared by reaction of HAm with a compound of Formula IV or in the case where n is 1 or 2 by reaction of a compound II with (Z is halogen or tosyloxy). Intermediates of Formula IV above are prepared by reaction of with an intermediate of Formula II above obtained by the demethylation of the corresponding methyl ether starting material followed by halogenation. Pharmaceutical compositions in conventional forms for oral or rectal administration comprise an above novel compound and a carrier or diluent. The compositions are of use in the treatment of heart conditions. [GB1357212A]
IE790/72A 1971-06-25 1972-06-07 Benzothiophene derivatives and process for preparing same IE36485B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3003271A GB1357212A (en) 1971-06-25 1971-06-25 Benzothiophene derivatives and process for preparing the same

Publications (2)

Publication Number Publication Date
IE36485L IE36485L (en) 1972-12-25
IE36485B1 true IE36485B1 (en) 1976-11-10

Family

ID=10301169

Family Applications (1)

Application Number Title Priority Date Filing Date
IE790/72A IE36485B1 (en) 1971-06-25 1972-06-07 Benzothiophene derivatives and process for preparing same

Country Status (18)

Country Link
JP (1) JPS4844248A (en)
AT (1) AT312597B (en)
AU (1) AU462617B2 (en)
BE (1) BE784260A (en)
CA (1) CA959492A (en)
CH (2) CH548409A (en)
DE (1) DE2230669A1 (en)
ES (1) ES404252A1 (en)
FI (1) FI54477C (en)
FR (1) FR2143250B1 (en)
GB (1) GB1357212A (en)
HU (1) HU166255B (en)
IE (1) IE36485B1 (en)
NL (1) NL7208703A (en)
OA (1) OA04117A (en)
SE (1) SE385482B (en)
SU (2) SU453844A3 (en)
ZA (1) ZA723868B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
JPS5973579A (en) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk Benzofuran or benzothiophene derivative, diuretic agent containing said compound as active constituent and preparation thereof
NO174506B (en) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogous procedure for the preparation of therapeutically active compounds
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals

Also Published As

Publication number Publication date
FI54477B (en) 1978-08-31
FR2143250A1 (en) 1973-02-02
AT312597B (en) 1974-01-10
ZA723868B (en) 1973-03-28
DE2230669A1 (en) 1972-12-28
CH548409A (en) 1974-04-30
SE385482B (en) 1976-07-05
SU453844A3 (en) 1974-12-15
OA04117A (en) 1979-11-30
CA959492A (en) 1974-12-17
CH549042A (en) 1974-05-15
ES404252A1 (en) 1975-06-01
JPS4844248A (en) 1973-06-26
FR2143250B1 (en) 1975-06-20
BE784260A (en) 1972-12-01
HU166255B (en) 1975-02-28
FI54477C (en) 1978-12-11
AU4333872A (en) 1973-12-20
NL7208703A (en) 1972-12-28
SU486510A3 (en) 1975-09-30
IE36485L (en) 1972-12-25
GB1357212A (en) 1974-06-19
AU462617B2 (en) 1975-06-10

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