IE35968L - s-TRIAZOLO [4, 3-a] [1, 4] BENZODIAZEPINES - Google Patents
s-TRIAZOLO [4, 3-a] [1, 4] BENZODIAZEPINESInfo
- Publication number
- IE35968L IE35968L IE720038A IE3872A IE35968L IE 35968 L IE35968 L IE 35968L IE 720038 A IE720038 A IE 720038A IE 3872 A IE3872 A IE 3872A IE 35968 L IE35968 L IE 35968L
- Authority
- IE
- Ireland
- Prior art keywords
- substd
- opt
- alkyl
- give
- r2hn
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cpds of formula (I): (where Q is NR2R3;R1 is H or 1-3C alkyl, R2 and R3 are H, 1-6C alkyl, 2-6C hydroxyalkyl or 7-9C aralkyl, or NR2R3 is 5- to 7- membered polymethyleneimino or morpholino, both opt. substd by lower alkyl and contg. =10C; A is 1-3C alkylene, rings B and C are opt substd by F,Cl,Br,CF3,NO2,1-6C alkyl or alkoxy) and their 5-oxides and acid addn salts are CNS depressants. They may be prepd. by reacting a reactive ester of (I;Q=OH) with R2R3NH or its alkali metal deriv; reacting a 2-X-3-R1-5-Ph-3H-1,4-benzodiazepine with R2R3NACONHNH2 (where X=SH lower alkoxy or alkylthio (opt. activated by a substd) or opt. substd amino); hydrolysis of (I;Q=R2R3'N) (where R3'=acyl) to give (I;Q=R2HN); reaction of (I;Q=phthalimido) with N2H4 and/or strong acid to give (I;Q=NH2); redn of (I;Q=N3) to give (I;Q=NH2); or reaction of (IfQ=R2HN) with a 1-6C satd aliphatic oxo cpd and reducing the product.
[CH544764A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH89171 | 1971-01-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35968L true IE35968L (en) | 1972-07-21 |
| IE35968B1 IE35968B1 (en) | 1976-07-07 |
Family
ID=4197579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE38/72A IE35968B1 (en) | 1971-01-21 | 1972-01-11 | Diazepine derivatives and processes for their production |
Country Status (19)
| Country | Link |
|---|---|
| AR (1) | AR192612A1 (en) |
| AT (3) | AT315848B (en) |
| AU (1) | AU475348B2 (en) |
| BE (1) | BE778215A (en) |
| CA (1) | CA965786A (en) |
| CH (2) | CH544764A (en) |
| CS (2) | CS185640B2 (en) |
| DD (1) | DD95010A5 (en) |
| DE (1) | DE2201210A1 (en) |
| ES (1) | ES399064A1 (en) |
| FR (1) | FR2122485B1 (en) |
| GB (2) | GB1393256A (en) |
| HU (1) | HU166550B (en) |
| IE (1) | IE35968B1 (en) |
| IL (1) | IL38553A (en) |
| NL (1) | NL7200538A (en) |
| PL (2) | PL83109B1 (en) |
| SU (1) | SU481156A3 (en) |
| ZA (1) | ZA72253B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4932874B1 (en) | 1970-12-11 | 1974-09-03 | ||
| GB1381158A (en) * | 1971-09-13 | 1975-01-22 | Upjohn Co | Benzodiazepines and the manufacture thereof |
| US3767661A (en) * | 1971-09-13 | 1973-10-23 | Upjohn Co | 4h-s-triazolo(4,3-a)(1,4)benzodiazepines |
| US3767660A (en) * | 1971-09-13 | 1973-10-23 | Upjohn Co | 4h-s-triazolo(4,3-a)(1,4)benzodiazepines |
| BE790838A (en) * | 1971-11-02 | 1973-04-30 | Upjohn Co | NEWS 1-AMINOPHENYL-6-PHENYL-S-TRIAZOLO (4,3-A) (1,4) - BENZODIAZEPINES, THEIR METHOD OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM |
| DE2356369C2 (en) * | 1972-11-24 | 1984-08-23 | The Upjohn Co., Kalamazoo, Mich. | Pharmaceutical preparation containing one or more benzodiazepine compounds |
| US3842090A (en) * | 1973-02-14 | 1974-10-15 | Upjohn Co | Certain 1-aminomethyl-6-phenyl 4h-s-triazolo(4,3-a)(1,4)benzodiazepines |
| US4009175A (en) * | 1976-03-15 | 1977-02-22 | The Upjohn Company | 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines |
| US4501698A (en) * | 1983-03-31 | 1985-02-26 | The Upjohn Company | Preparing 1-(hydroxymethyl)-triazolobenzodiazepines and 1-(aminomethyl)-triazolobenzodiazepines |
| CA1234810A (en) * | 1983-12-19 | 1988-04-05 | Steve Nichols | Non-hygroscopic adinazolam methanesulfonate salt and process therefor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
1971
- 1971-01-21 CH CH1206173A patent/CH544764A/en not_active IP Right Cessation
- 1971-01-21 CH CH89171A patent/CH545803A/xx not_active IP Right Cessation
-
1972
- 1972-01-11 IE IE38/72A patent/IE35968B1/en unknown
- 1972-01-12 CA CA132,223A patent/CA965786A/en not_active Expired
- 1972-01-12 DE DE19722201210 patent/DE2201210A1/en active Pending
- 1972-01-13 NL NL7200538A patent/NL7200538A/xx not_active Application Discontinuation
- 1972-01-13 IL IL38553A patent/IL38553A/en unknown
- 1972-01-14 GB GB184472A patent/GB1393256A/en not_active Expired
- 1972-01-14 GB GB4320574A patent/GB1394568A/en not_active Expired
- 1972-01-14 ZA ZA720253A patent/ZA72253B/en unknown
- 1972-01-18 FR FR7201534A patent/FR2122485B1/fr not_active Expired
- 1972-01-19 HU HUCI1202A patent/HU166550B/hu unknown
- 1972-01-19 AU AU38047/72A patent/AU475348B2/en not_active Expired
- 1972-01-19 SU SU1959120A patent/SU481156A3/en active
- 1972-01-19 BE BE778215A patent/BE778215A/en unknown
- 1972-01-20 ES ES399064A patent/ES399064A1/en not_active Expired
- 1972-01-20 PL PL1972153001A patent/PL83109B1/en unknown
- 1972-01-20 AT AT46372A patent/AT315848B/en not_active IP Right Cessation
- 1972-01-20 PL PL1972175725A patent/PL86933B1/en unknown
- 1972-01-20 AT AT501873A patent/AT315862B/en not_active IP Right Cessation
- 1972-01-20 CS CS7500008670A patent/CS185640B2/en unknown
- 1972-01-20 DD DD160445A patent/DD95010A5/xx unknown
- 1972-01-20 CS CS7200000387A patent/CS185604B2/en unknown
- 1972-01-20 AT AT501973A patent/AT315863B/en not_active IP Right Cessation
- 1972-01-21 AR AR240178A patent/AR192612A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SU481156A3 (en) | 1975-08-15 |
| AU3804772A (en) | 1973-07-26 |
| CA965786A (en) | 1975-04-08 |
| CH545803A (en) | 1974-02-15 |
| GB1394568A (en) | 1975-05-21 |
| IL38553A0 (en) | 1972-03-28 |
| CS185640B2 (en) | 1978-10-31 |
| FR2122485A1 (en) | 1972-09-01 |
| DD95010A5 (en) | 1973-01-12 |
| IL38553A (en) | 1975-02-10 |
| CS185604B2 (en) | 1978-10-31 |
| BE778215A (en) | 1972-07-19 |
| NL7200538A (en) | 1972-07-25 |
| GB1393256A (en) | 1975-05-07 |
| FR2122485B1 (en) | 1975-02-07 |
| PL83109B1 (en) | 1975-12-31 |
| AU475348B2 (en) | 1976-08-19 |
| HU166550B (en) | 1975-04-28 |
| AT315863B (en) | 1974-06-10 |
| IE35968B1 (en) | 1976-07-07 |
| SU444370A3 (en) | 1974-09-25 |
| PL86933B1 (en) | 1976-06-30 |
| AT315848B (en) | 1974-06-10 |
| DE2201210A1 (en) | 1972-08-03 |
| AT315862B (en) | 1974-06-10 |
| ES399064A1 (en) | 1975-06-01 |
| ZA72253B (en) | 1972-09-27 |
| CH544764A (en) | 1974-01-15 |
| AR192612A1 (en) | 1973-02-28 |
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