IE35723L - Quinazolone derivatives - Google Patents
Quinazolone derivativesInfo
- Publication number
- IE35723L IE35723L IE711281A IE128171A IE35723L IE 35723 L IE35723 L IE 35723L IE 711281 A IE711281 A IE 711281A IE 128171 A IE128171 A IE 128171A IE 35723 L IE35723 L IE 35723L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- cycloalkyl
- oct
- alkyl
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 abstract 1
- 101500021084 Locusta migratoria 5 kDa peptide Proteins 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DDKMFOUTRRODRE-UHFFFAOYSA-N chloromethanone Chemical compound Cl[C]=O DDKMFOUTRRODRE-UHFFFAOYSA-N 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 125000005442 diisocyanate group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Making Paper Articles (AREA)
Abstract
1333284 Quinazoline derived biscarbamates BAYER AG 11 Oct 1971 [13 Oct 1970] 47212/71 Heading C2C The invention comprises compounds of formula wherein X is O or S, R is alkyl (optionally with its C chain interrupted by O or S), cycloalkyl, aralkyl or aryl, R<SP>1</SP> is alkyl, cycloalkyl or Ph, and any hydrocarbon radicals mentioned may be substituted. In examples, these compounds are prepared by reacting (1) the corresponding diisocyanate or diisothiocyanate with ROH, or (2) the corresponding diamine with ClCO 2 R, or (to obtain a product where R is 2-hydroxyethyl) glycol carbonate. Therapeutic compositions having cytostatic activity comprise compounds of the above formula, and may be administered orally, parenterally or rectally.
[GB1333284A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2050092A DE2050092C3 (en) | 1970-10-13 | 1970-10-13 | Chinazolone diurethanes, processes for their manufacture, and medicines containing these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35723L true IE35723L (en) | 1972-04-13 |
| IE35723B1 IE35723B1 (en) | 1976-04-28 |
Family
ID=5784901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1281/71A IE35723B1 (en) | 1970-10-13 | 1971-10-12 | New quinazolone derivatives their production and their medicinal use |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS551261B1 (en) |
| AR (1) | AR203366A1 (en) |
| AT (2) | AT312630B (en) |
| AU (1) | AU452967B2 (en) |
| BE (1) | BE773818A (en) |
| BR (1) | BR7106855D0 (en) |
| CH (2) | CH564540A5 (en) |
| CS (1) | CS200248B2 (en) |
| DD (1) | DD95568A5 (en) |
| DE (1) | DE2050092C3 (en) |
| DK (1) | DK129163B (en) |
| ES (2) | ES395942A1 (en) |
| FI (1) | FI56967C (en) |
| FR (1) | FR2110395B1 (en) |
| GB (1) | GB1333284A (en) |
| HU (1) | HU162725B (en) |
| IE (1) | IE35723B1 (en) |
| IL (1) | IL37888A (en) |
| NL (1) | NL7114093A (en) |
| NO (1) | NO133498C (en) |
| SE (1) | SE380523B (en) |
| SU (1) | SU448647A3 (en) |
| YU (1) | YU34682B (en) |
| ZA (1) | ZA716807B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4343940A (en) | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
| WO2002028841A2 (en) * | 2000-10-02 | 2002-04-11 | Molecular Probes, Inc. | Reagents for labeling biomolecules having aldehyde or ketone moieties |
-
1970
- 1970-10-13 DE DE2050092A patent/DE2050092C3/en not_active Expired
-
1971
- 1971-09-28 AU AU33937/71A patent/AU452967B2/en not_active Expired
- 1971-10-08 IL IL37888A patent/IL37888A/en unknown
- 1971-10-11 GB GB4721271A patent/GB1333284A/en not_active Expired
- 1971-10-11 FI FI2837/71A patent/FI56967C/en active
- 1971-10-11 SU SU1848109A patent/SU448647A3/en active
- 1971-10-12 JP JP7994371A patent/JPS551261B1/ja active Pending
- 1971-10-12 NO NO3744/71A patent/NO133498C/no unknown
- 1971-10-12 DD DD158236A patent/DD95568A5/xx unknown
- 1971-10-12 CH CH1486971A patent/CH564540A5/xx not_active IP Right Cessation
- 1971-10-12 CH CH1139374A patent/CH562808A5/xx not_active IP Right Cessation
- 1971-10-12 DK DK494471AA patent/DK129163B/en unknown
- 1971-10-12 SE SE7112932A patent/SE380523B/en unknown
- 1971-10-12 BE BE773818A patent/BE773818A/en unknown
- 1971-10-12 ZA ZA716807A patent/ZA716807B/en unknown
- 1971-10-12 IE IE1281/71A patent/IE35723B1/en unknown
- 1971-10-13 NL NL7114093A patent/NL7114093A/xx not_active Application Discontinuation
- 1971-10-13 ES ES395942A patent/ES395942A1/en not_active Expired
- 1971-10-13 AT AT1018372A patent/AT312630B/en not_active IP Right Cessation
- 1971-10-13 YU YU2600/71A patent/YU34682B/en unknown
- 1971-10-13 HU HUBA2657A patent/HU162725B/hu unknown
- 1971-10-13 AT AT884571A patent/AT312628B/en not_active IP Right Cessation
- 1971-10-13 FR FR7136765A patent/FR2110395B1/fr not_active Expired
- 1971-10-13 CS CS717189A patent/CS200248B2/en unknown
- 1971-10-13 BR BR006855/71A patent/BR7106855D0/en unknown
- 1971-12-18 ES ES398118A patent/ES398118A1/en not_active Expired
-
1972
- 1972-09-19 AR AR244160A patent/AR203366A1/en active
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