IE34629B1 - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
IE34629B1
IE34629B1 IE851/70A IE85170A IE34629B1 IE 34629 B1 IE34629 B1 IE 34629B1 IE 851/70 A IE851/70 A IE 851/70A IE 85170 A IE85170 A IE 85170A IE 34629 B1 IE34629 B1 IE 34629B1
Authority
IE
Ireland
Prior art keywords
alkyl
derivative
hydrolysing
treating
product
Prior art date
Application number
IE851/70A
Other versions
IE34629L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IE209/73A priority Critical patent/IE34631B1/en
Priority to IE208/73A priority patent/IE34630B1/en
Publication of IE34629L publication Critical patent/IE34629L/en
Publication of IE34629B1 publication Critical patent/IE34629B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1304707 Benzodiazepines F HOFFMANNLA ROCHE & CO AG 30 June 1970 [2 July 1969 17 Nov 1969 15 April 1970 4 May 1970 13 May 1970] 31501/70 Heading C2C Compounds of the general formula (B=CH 2 , CO; R 1,3,4 =H, C 1-7 alkyl; R 2 =H, halogen) are prepared by (a) diazotizing a corresponding 7-amino derivative, treating the diazonium salt with an alkanoyl group-providing agent and hydrolysing the product, (b) ring- closing a compound of the formula (c) treating a corresponding 7-cyano derivative with an alkyl lithium and hydrolysing the product (B = CH 2 when R 1 = alkyl) or (d) oxidizing the α-methylene group in a corresponding 7-(C 1-8 alkyl) derivative, optionally followed in each case by N-alkylation and/or oxidation of B = CH2 to B=CO. The above compounds are anticonvulsants, muscle relaxants and sedatives and may be administered in the form of pharmaceutical preparations containing them, with or without other (unspecified) active ingredients, in association with a carrier. [GB1304707A]
IE851/70A 1969-07-02 1970-06-30 Benzodiazepine derivatives IE34629B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE209/73A IE34631B1 (en) 1970-04-15 1970-06-30 Benzophenone derivatives
IE208/73A IE34630B1 (en) 1970-04-15 1970-06-30 Benzophenone derivatives

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83867769A 1969-07-02 1969-07-02
US87749069A 1969-11-17 1969-11-17
US2893570A 1970-04-15 1970-04-15
US3453270A 1970-05-04 1970-05-04
US3702170A 1970-05-13 1970-05-13

Publications (2)

Publication Number Publication Date
IE34629L IE34629L (en) 1971-01-02
IE34629B1 true IE34629B1 (en) 1975-07-09

Family

ID=27534252

Family Applications (1)

Application Number Title Priority Date Filing Date
IE851/70A IE34629B1 (en) 1969-07-02 1970-06-30 Benzodiazepine derivatives

Country Status (13)

Country Link
JP (1) JPS4833759B1 (en)
BE (1) BE752832A (en)
CH (1) CH548404A (en)
DE (1) DE2032907A1 (en)
DK (1) DK140282B (en)
FR (1) FR2059466B1 (en)
GB (1) GB1304707A (en)
HU (1) HU164057B (en)
IE (1) IE34629B1 (en)
IL (1) IL34816A (en)
NL (1) NL7009788A (en)
NO (1) NO125930B (en)
SE (1) SE370700B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL120864C (en) * 1945-04-26

Also Published As

Publication number Publication date
JPS4833759B1 (en) 1973-10-16
IL34816A0 (en) 1970-08-19
IE34629L (en) 1971-01-02
NL7009788A (en) 1971-01-05
DK140282B (en) 1979-07-23
NO125930B (en) 1972-11-27
CH548404A (en) 1974-04-30
DK140282C (en) 1979-12-17
GB1304707A (en) 1973-01-31
FR2059466B1 (en) 1975-04-18
SE370700B (en) 1974-10-28
IL34816A (en) 1973-08-29
HU164057B (en) 1973-12-28
BE752832A (en) 1971-01-04
DE2032907A1 (en) 1971-01-07
FR2059466A1 (en) 1971-06-04

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