IE34588B1 - Improvements in or relating to penicillin esters - Google Patents

Improvements in or relating to penicillin esters

Info

Publication number
IE34588B1
IE34588B1 IE656/70A IE65670A IE34588B1 IE 34588 B1 IE34588 B1 IE 34588B1 IE 656/70 A IE656/70 A IE 656/70A IE 65670 A IE65670 A IE 65670A IE 34588 B1 IE34588 B1 IE 34588B1
Authority
IE
Ireland
Prior art keywords
degrees
pref
relating
phenol
alcohol
Prior art date
Application number
IE656/70A
Other versions
IE34588L (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE34588L publication Critical patent/IE34588L/en
Publication of IE34588B1 publication Critical patent/IE34588B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Penicillin esters (I) are produced by (a) contacting a salt of penicillanic acid with a chloroformic or bromo-formic acid with an alcohol or phenol (pref. 2,2,2-trichloroethanol), in an inert, anhydrous organic solvent, pref. at -20 degrees to + 30 degrees C, and in the absence of a substantial excess of base, until a mixed anhydride (II) is obtained, (b) decarboxylating II by contact with a weak tertiary base (pref. at -10 degrees to + 30 degrees C), to obtain I, and the alcohol or phenol I are intermediates for penicillins and cephalosporins. [FR2048490A5]
IE656/70A 1969-05-20 1970-05-19 Improvements in or relating to penicillin esters IE34588B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2574669 1969-05-20
GB3638569 1969-07-18

Publications (2)

Publication Number Publication Date
IE34588L IE34588L (en) 1970-11-20
IE34588B1 true IE34588B1 (en) 1975-06-25

Family

ID=26257851

Family Applications (1)

Application Number Title Priority Date Filing Date
IE656/70A IE34588B1 (en) 1969-05-20 1970-05-19 Improvements in or relating to penicillin esters

Country Status (9)

Country Link
AT (1) AT310351B (en)
BE (1) BE750558A (en)
CH (1) CH555858A (en)
DE (1) DE2024359A1 (en)
ES (1) ES379816A1 (en)
FR (1) FR2048490A5 (en)
IE (1) IE34588B1 (en)
IL (1) IL34551A (en)
NL (1) NL7007192A (en)

Also Published As

Publication number Publication date
AT310351B (en) 1973-09-25
IE34588L (en) 1970-11-20
FR2048490A5 (en) 1971-03-19
BE750558A (en) 1970-11-19
IL34551A (en) 1974-06-30
CH555858A (en) 1974-11-15
ES379816A1 (en) 1972-09-16
IL34551A0 (en) 1970-07-19
NL7007192A (en) 1970-11-24
DE2024359A1 (en) 1970-11-26

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