IE33835B1 - New peptides and process for their manufacture - Google Patents
New peptides and process for their manufactureInfo
- Publication number
- IE33835B1 IE33835B1 IE1403/69A IE140369A IE33835B1 IE 33835 B1 IE33835 B1 IE 33835B1 IE 1403/69 A IE1403/69 A IE 1403/69A IE 140369 A IE140369 A IE 140369A IE 33835 B1 IE33835 B1 IE 33835B1
- Authority
- IE
- Ireland
- Prior art keywords
- thr
- gly
- ala
- phe
- boc
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108010079364 N-glycylalanine Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 3
- 108010037850 glycylvaline Proteins 0.000 abstract 3
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- FHOAKXBXYSJBGX-YFKPBYRVSA-N (2s)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@@H](CO)C(O)=O FHOAKXBXYSJBGX-YFKPBYRVSA-N 0.000 abstract 1
- 229940121799 Hypocalcaemic agent Drugs 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- XZONQWUEBAFQPO-HJGDQZAQSA-N Pro-Gln-Thr Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XZONQWUEBAFQPO-HJGDQZAQSA-N 0.000 abstract 1
- PXQUBKWZENPDGE-CIQUZCHMSA-N Thr-Ala-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)N PXQUBKWZENPDGE-CIQUZCHMSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical class N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 108010092114 histidylphenylalanine Proteins 0.000 abstract 1
- BPISBTXISIPAEQ-XPUUQOCRSA-N methyl 2-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]acetate Chemical compound CC[C@H](C)[C@H](N)C(=O)NCC(=O)OC BPISBTXISIPAEQ-XPUUQOCRSA-N 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- GEMSXPOJLIUVKT-IUCAKERBSA-N tert-butyl (2s)-1-[(2s)-2-aminopropanoyl]pyrrolidine-2-carboxylate Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C GEMSXPOJLIUVKT-IUCAKERBSA-N 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1540168A CH550774A (de) | 1968-10-15 | 1968-10-15 | Verfahren zur herstellung neuer hypocalcaemischer peptide. |
| CH1728668 | 1968-11-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33835L IE33835L (en) | 1970-04-15 |
| IE33835B1 true IE33835B1 (en) | 1974-11-13 |
Family
ID=25716344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1403/69A IE33835B1 (en) | 1968-10-15 | 1969-10-10 | New peptides and process for their manufacture |
Country Status (11)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50117791A (enrdf_load_stackoverflow) * | 1974-03-07 | 1975-09-16 | ||
| US3929758A (en) * | 1974-09-12 | 1975-12-30 | Armour Pharma | Cyclization of cysteine-containing peptides |
| DE2602443A1 (de) | 1975-04-04 | 1976-10-21 | Univ California | Biologisch aktive polypeptide |
| AT367453B (de) | 1980-04-03 | 1982-07-12 | Voest Alpine Ag | Verfahren und vorrichtung zur herstellung von fluessigem roheisen oder stahlvormaterial |
| US4401593A (en) * | 1982-02-12 | 1983-08-30 | Armour Pharmaceutical Company | Glycine - 8 calcitonin |
| DE3822394A1 (de) * | 1988-07-01 | 1990-01-04 | Walter Frenkel | Massagegeraet mit abnehmbarem griff |
| CS89491A3 (en) * | 1990-04-09 | 1992-01-15 | Chugai Pharmaceutical Co Ltd | Hybrid calcitonin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5835M (enrdf_load_stackoverflow) * | 1965-07-30 | 1968-03-04 | ||
| GB1230631A (enrdf_load_stackoverflow) * | 1967-05-12 | 1971-05-05 | ||
| CA919590A (en) * | 1967-05-24 | 1973-01-23 | Neher Robert | Process for the manufacture of thyrocalcitonin |
-
1969
- 1969-10-08 DE DE19691950711 patent/DE1950711A1/de active Pending
- 1969-10-10 IE IE1403/69A patent/IE33835B1/xx unknown
- 1969-10-13 GB GB50087/69A patent/GB1287125A/en not_active Expired
- 1969-10-13 SE SE14000/69A patent/SE366543B/xx unknown
- 1969-10-13 SE SE7216700A patent/SE374913B/xx unknown
- 1969-10-14 BE BE740256D patent/BE740256A/xx unknown
- 1969-10-14 AT AT172971A patent/AT313491B/de not_active IP Right Cessation
- 1969-10-14 HU HUCI929A patent/HU166686B/hu unknown
- 1969-10-14 FR FR6935098A patent/FR2020730B1/fr not_active Expired
- 1969-10-14 DK DK545669AA patent/DK129338B/da unknown
- 1969-10-14 AT AT966769A patent/AT300210B/de not_active IP Right Cessation
- 1969-10-14 NL NL6915540A patent/NL6915540A/xx unknown
- 1969-10-15 CS CS686369A patent/CS155219B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1950711A1 (de) | 1970-04-30 |
| FR2020730A1 (enrdf_load_stackoverflow) | 1970-07-17 |
| IE33835L (en) | 1970-04-15 |
| GB1287125A (en) | 1972-08-31 |
| SE366543B (enrdf_load_stackoverflow) | 1974-04-29 |
| FR2020730B1 (enrdf_load_stackoverflow) | 1974-04-12 |
| SE374913B (enrdf_load_stackoverflow) | 1975-03-24 |
| DK129338B (da) | 1974-09-30 |
| HU166686B (enrdf_load_stackoverflow) | 1975-05-28 |
| CS155219B2 (enrdf_load_stackoverflow) | 1974-05-30 |
| NL6915540A (enrdf_load_stackoverflow) | 1970-04-17 |
| AT300210B (de) | 1972-07-25 |
| AT313491B (de) | 1974-02-25 |
| DK129338C (enrdf_load_stackoverflow) | 1975-02-17 |
| BE740256A (enrdf_load_stackoverflow) | 1970-04-14 |
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