IE33502B1 - Analgesic compositions - Google Patents

Analgesic compositions

Info

Publication number
IE33502B1
IE33502B1 IE1066/69A IE106669A IE33502B1 IE 33502 B1 IE33502 B1 IE 33502B1 IE 1066/69 A IE1066/69 A IE 1066/69A IE 106669 A IE106669 A IE 106669A IE 33502 B1 IE33502 B1 IE 33502B1
Authority
IE
Ireland
Prior art keywords
methyl
phenoxyphenyl
hydrogen
analgesic
agent
Prior art date
Application number
IE1066/69A
Other versions
IE33502L (en
Inventor
Jr J A Miller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE33502L publication Critical patent/IE33502L/en
Publication of IE33502B1 publication Critical patent/IE33502B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,250,582. Analgesic compositions. ELI LILLY & CO. 14 Aug., 1969 [15 Aug., 1968 (2)], No. 40770/69. Heading A5B. An analgesic composition comprises a narcotic analgesic agent and a 3- or 4-phenoxyphenylalkanoic acid potentiating agent of the formula or a pharmaceutically acceptable salt thereof, wherein (a) the phenoxy moiety is in the 3- position, R<SP>3</SP> is methyl or ethyl and R<SP>4</SP> is hydrogen, (b) the phenoxy moiety is in the 4-position, R<SP>3</SP> is hydrogen or methyl and when R<SP>3</SP> is hydrogen R<SP>4</SP> is hydrogen, fluoro, ethyl, methyl or methoxy and when R<SP>3</SP> is methyl R<SP>4</SP> is hydrogen. The narcotic analgesic agent may be codeine, morphine, methadon, meperidine, versidyne [1 - (p - chlorophenethyl) - 6,7 - dimethoxy - 2 - methyl - 1,2,3,4 - tetrahydroisoquinoline] or m - (1 - methyl - 3 - propyl - 3 - pyrrolidinyl) phenol. The phenoxyphenyl compound may be in the form of the Na, K, Ca, Mg, ammonium or benzylammonium salt. Preferred phenoxyphenyl compounds include 2 - (3 - phenoxyphenyl) propionic, 2 - (3 - methyl - 4 - phenoxyphenyl) acetic, 2 - (3 - phenoxyphenyl) butyric and 2 - (4 - phenoxyphenyl)- propionic acids. The compositions may be administered orally as tablets, pills, powders, granules, capsules, emulsions, solutions, suspensions, syrups, and elixirs; parenterally in the form of sterile aqueous or non-aqueous solutions, suspensions or emulsions; or rectally as suppositories. The compositions may contain additional active ingredients. The analgesic activity of a narcotic analgesic agent is enhanced by administering, either simultaneously or from one hour before to one hour after the administration of the analgesic, the above potentiating agent. [GB1250582A]
IE1066/69A 1968-08-15 1969-07-31 Analgesic compositions IE33502B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75278868A 1968-08-15 1968-08-15
US75278768A 1968-08-15 1968-08-15

Publications (2)

Publication Number Publication Date
IE33502L IE33502L (en) 1970-02-15
IE33502B1 true IE33502B1 (en) 1974-07-24

Family

ID=27115647

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1066/69A IE33502B1 (en) 1968-08-15 1969-07-31 Analgesic compositions

Country Status (12)

Country Link
BE (1) BE737415A (en)
CA (1) CA974451A (en)
CY (1) CY782A (en)
DE (1) DE1941583C3 (en)
FR (1) FR2015729B1 (en)
GB (1) GB1250582A (en)
IE (1) IE33502B1 (en)
IL (1) IL32781A (en)
LU (1) LU59283A1 (en)
MY (1) MY7500035A (en)
NL (1) NL161669C (en)
SE (1) SE374269B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU528532B2 (en) * 1978-12-18 1983-05-05 Mcniel Laboratories Acetaminophen analgesic potentiation
JPS584720A (en) * 1981-06-26 1983-01-11 ザ・アツプジヨン・カンパニ− Analgesic medicinal composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU38115A1 (en) * 1959-01-07

Also Published As

Publication number Publication date
BE737415A (en) 1970-02-13
DE1941583C3 (en) 1980-06-04
CA974451A (en) 1975-09-16
IE33502L (en) 1970-02-15
CY782A (en) 1975-03-01
SE374269B (en) 1975-03-03
NL161669C (en) 1980-03-17
NL161669B (en) 1979-10-15
DE1941583B2 (en) 1979-08-23
NL6912502A (en) 1970-02-17
DE1941583A1 (en) 1970-07-09
IL32781A (en) 1974-01-14
FR2015729B1 (en) 1974-02-01
MY7500035A (en) 1975-12-31
LU59283A1 (en) 1970-02-13
FR2015729A1 (en) 1970-04-30
GB1250582A (en) 1971-10-20
IL32781A0 (en) 1969-12-31

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