IE33374L - 7-aminocephalosporanic acid - Google Patents
7-aminocephalosporanic acidInfo
- Publication number
- IE33374L IE33374L IE690828A IE82869A IE33374L IE 33374 L IE33374 L IE 33374L IE 690828 A IE690828 A IE 690828A IE 82869 A IE82869 A IE 82869A IE 33374 L IE33374 L IE 33374L
- Authority
- IE
- Ireland
- Prior art keywords
- aminocephalosporanic acid
- oxide
- added
- propiolactone
- aca
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04F—FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
- E04F21/00—Implements for finishing work on buildings
- E04F21/02—Implements for finishing work on buildings for applying plasticised masses to surfaces, e.g. plastering walls
- E04F21/06—Implements for applying plaster, insulating material, or the like
- E04F21/08—Mechanical implements
- E04F21/12—Mechanical implements acting by gas pressure, e.g. steam pressure
Landscapes
- Engineering & Computer Science (AREA)
- Architecture (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1281172 Preparing 7-aminocephalosporanic acid ELI LILLY & CO 17 June 1969 [19 June 1968 (2)] 30674/69 Heading C2A 7-Aminocephalosporanic acid is prepared by a process of reacting cephalosporin C or a salt thereof with a nitrosating agent, a carbocyclic arenediazonium salt or a compound that provides positive halogen, at a temperature below 60 C. in a solvent, and hydrolysing the resulting intermediate to give the 7-aminocephalosporanic acid, in which process an alkylene oxide containing 2 to 4 carbon atoms or #-propiolactone is added to the reaction mixture to obtain the 7- aminocephalosporanic acid. The alkylene oxide or propiolactone may be added to the hydrolysed reaction mixture resulting from treatment of the intermediate with water and/or a C 1 -C 3 alkanol, in which case its function is to precipitate the 7-aminocephalosporanic acid (7-ACA). Alternatively it may be added to the residue left after evaporating the reaction solvent before hydrolysis, when hydrolysis is brought about without the use of water and/or alkanol and 7- ACA is precipitated directly on adding the alkylene oxide or propiolactone. The reaction solvent is preferably a mixture of formic acid and nitroalkane with or without acetonitrile. Excess of the nitrosating agent, arenediazonium salt or compound providing halogen is preferably destroyed after the reaction, e.g. by adding ammonium sulphamate. Suitable alkylene oxides are ethylene oxide (i.e. oxirane), 1,2- propylene oxide, butene-1-oxide and butene-2- oxide. They may be added in a solvent, preferably all at once, suitable solvents being acetonitrile, ketones, esters, dioxane and tetrahydrofuran, which are poor solvents for the 7-ACA. 3-30 moles of alkylene oxide per mole of cephalosporin C starting material are used. Reference has been directed by the Comptroller to Specification 948858.
[GB1281172A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73808568A | 1968-06-19 | 1968-06-19 | |
US73808468A | 1968-06-19 | 1968-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE33374L true IE33374L (en) | 1969-12-19 |
IE33374B1 IE33374B1 (en) | 1974-06-12 |
Family
ID=27113310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE828/69A IE33374B1 (en) | 1968-06-19 | 1969-06-17 | Improved process for preparing 7-aminocephalosporanic acid |
Country Status (10)
Country | Link |
---|---|
AT (1) | AT292920B (en) |
BE (1) | BE734720A (en) |
CH (1) | CH513208A (en) |
DE (1) | DE1930956C3 (en) |
FR (1) | FR2011244A1 (en) |
GB (1) | GB1281172A (en) |
IE (1) | IE33374B1 (en) |
IL (1) | IL32407A (en) |
NL (1) | NL6909332A (en) |
SE (1) | SE369603B (en) |
-
1969
- 1969-06-17 IL IL32407A patent/IL32407A/en unknown
- 1969-06-17 GB GB30674/69A patent/GB1281172A/en not_active Expired
- 1969-06-17 IE IE828/69A patent/IE33374B1/en unknown
- 1969-06-18 BE BE734720D patent/BE734720A/xx unknown
- 1969-06-18 SE SE08648/69A patent/SE369603B/xx unknown
- 1969-06-18 NL NL6909332A patent/NL6909332A/xx unknown
- 1969-06-19 AT AT582469A patent/AT292920B/en not_active IP Right Cessation
- 1969-06-19 FR FR6920591A patent/FR2011244A1/fr not_active Withdrawn
- 1969-06-19 CH CH939769A patent/CH513208A/en not_active IP Right Cessation
- 1969-06-19 DE DE1930956A patent/DE1930956C3/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL32407A0 (en) | 1969-08-27 |
BE734720A (en) | 1969-12-18 |
DE1930956C3 (en) | 1974-01-03 |
FR2011244A1 (en) | 1970-02-27 |
IE33374B1 (en) | 1974-06-12 |
DE1930956B2 (en) | 1973-05-30 |
SE369603B (en) | 1974-09-09 |
GB1281172A (en) | 1972-07-12 |
AT292920B (en) | 1971-09-10 |
DE1930956A1 (en) | 1970-01-02 |
NL6909332A (en) | 1969-12-23 |
CH513208A (en) | 1971-09-30 |
IL32407A (en) | 1973-05-31 |
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