IE32444B1 - (-) (cis-1,2-epoxypropyl)phosphonic acid derivatives - Google Patents
(-) (cis-1,2-epoxypropyl)phosphonic acid derivativesInfo
- Publication number
- IE32444B1 IE32444B1 IE1253/68A IE125368A IE32444B1 IE 32444 B1 IE32444 B1 IE 32444B1 IE 1253/68 A IE1253/68 A IE 1253/68A IE 125368 A IE125368 A IE 125368A IE 32444 B1 IE32444 B1 IE 32444B1
- Authority
- IE
- Ireland
- Prior art keywords
- salt
- epoxypropyl
- cis
- phosphonic acid
- reacting
- Prior art date
Links
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title abstract 2
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title abstract 2
- -1 methylene, ethylene, propylene Chemical group 0.000 abstract 9
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- 150000005690 diesters Chemical class 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical class [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000003512 tertiary amines Chemical class 0.000 abstract 2
- 150000003573 thiols Chemical class 0.000 abstract 2
- RQEUFEKYXDPUSK-SSDOTTSWSA-N (1R)-1-phenylethanamine Chemical class C[C@@H](N)C1=CC=CC=C1 RQEUFEKYXDPUSK-SSDOTTSWSA-N 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- ZJEHRMYJNACSLL-UHFFFAOYSA-N 1-[butoxy(chloro)phosphoryl]oxybutane Chemical compound CCCCOP(Cl)(=O)OCCCC ZJEHRMYJNACSLL-UHFFFAOYSA-N 0.000 abstract 1
- YYTYLIVWHBVGKW-UHFFFAOYSA-N 1-[butoxy(prop-1-ynyl)phosphoryl]oxybutane Chemical compound C(CCC)OP(OCCCC)(=O)C#CC YYTYLIVWHBVGKW-UHFFFAOYSA-N 0.000 abstract 1
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 abstract 1
- WUEAMTVQNGYLRI-UHFFFAOYSA-N 2-dichlorophosphoryl-1,3,5-tri(propan-2-yl)benzene Chemical compound CC(C)C1=CC(C(C)C)=C(P(Cl)(Cl)=O)C(C(C)C)=C1 WUEAMTVQNGYLRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- DRUIESSIVFYOMK-UHFFFAOYSA-N Trichloroacetonitrile Chemical compound ClC(Cl)(Cl)C#N DRUIESSIVFYOMK-UHFFFAOYSA-N 0.000 abstract 1
- XWCIXXXLOAAWPU-IHWYPQMZSA-N [(z)-prop-1-enyl]phosphonic acid Chemical compound C\C=C/P(O)(O)=O XWCIXXXLOAAWPU-IHWYPQMZSA-N 0.000 abstract 1
- DXMAARCZJITWJZ-UHFFFAOYSA-L [Mg+2].[Br-].[Br-].CC#C Chemical compound [Mg+2].[Br-].[Br-].CC#C DXMAARCZJITWJZ-UHFFFAOYSA-L 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 150000003009 phosphonic acids Chemical class 0.000 abstract 1
- XWCIXXXLOAAWPU-UHFFFAOYSA-N prop-1-enylphosphonic acid Chemical compound CC=CP(O)(O)=O XWCIXXXLOAAWPU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 150000003378 silver Chemical class 0.000 abstract 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72944468A | 1968-05-15 | 1968-05-15 | |
| US75580568A | 1968-08-28 | 1968-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32444L IE32444L (en) | 1969-11-15 |
| IE32444B1 true IE32444B1 (en) | 1973-08-08 |
Family
ID=27111879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1253/68A IE32444B1 (en) | 1968-05-15 | 1968-10-21 | (-) (cis-1,2-epoxypropyl)phosphonic acid derivatives |
Country Status (14)
| Country | Link |
|---|---|
| AT (3) | AT294120B (ro) |
| BE (1) | BE723075A (ro) |
| BG (1) | BG16345A3 (ro) |
| CH (1) | CH537953A (ro) |
| ES (1) | ES359543A1 (ro) |
| FR (1) | FR2008585B1 (ro) |
| GB (1) | GB1239986A (ro) |
| HU (1) | HU163312B (ro) |
| IE (1) | IE32444B1 (ro) |
| IL (1) | IL30921A0 (ro) |
| LU (1) | LU57188A1 (ro) |
| MT (1) | MTP594B (ro) |
| NL (1) | NL6814984A (ro) |
| ZM (1) | ZM14368A1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6814984A (ro) * | 1968-05-15 | 1969-11-18 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6814984A (ro) * | 1968-05-15 | 1969-11-18 |
-
1968
- 1968-10-18 NL NL6814984A patent/NL6814984A/xx unknown
- 1968-10-21 IE IE1253/68A patent/IE32444B1/xx unknown
- 1968-10-21 IL IL30921A patent/IL30921A0/xx unknown
- 1968-10-21 CH CH1570168A patent/CH537953A/de not_active IP Right Cessation
- 1968-10-24 GB GB50631/68A patent/GB1239986A/en not_active Expired
- 1968-10-25 ES ES359543A patent/ES359543A1/es not_active Expired
- 1968-10-25 HU HUME999A patent/HU163312B/hu unknown
- 1968-10-29 BE BE723075D patent/BE723075A/xx unknown
- 1968-10-29 BG BG010911A patent/BG16345A3/bg unknown
- 1968-10-29 LU LU57188D patent/LU57188A1/xx unknown
- 1968-10-30 AT AT1055868A patent/AT294120B/de not_active IP Right Cessation
- 1968-10-30 AT AT358770A patent/AT299247B/de not_active IP Right Cessation
- 1968-10-30 ZM ZM143/68A patent/ZM14368A1/xx unknown
- 1968-10-30 AT AT358870A patent/AT299246B/de not_active IP Right Cessation
- 1968-12-30 MT MT594A patent/MTP594B/xx unknown
-
1969
- 1969-05-14 FR FR6915696A patent/FR2008585B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH537953A (de) | 1973-06-15 |
| IL30921A0 (en) | 1968-12-26 |
| GB1239986A (en) | 1971-07-21 |
| DE1805682A1 (de) | 1969-12-11 |
| LU57188A1 (ro) | 1969-05-16 |
| FR2008585B1 (ro) | 1973-12-21 |
| AT299247B (de) | 1972-06-12 |
| AT294120B (de) | 1971-11-10 |
| HU163312B (ro) | 1973-07-28 |
| AT299246B (de) | 1972-06-12 |
| ZM14368A1 (en) | 1970-06-18 |
| NL6814984A (ro) | 1969-11-18 |
| BE723075A (ro) | 1969-04-29 |
| BG16345A3 (bg) | 1972-08-20 |
| IE32444L (en) | 1969-11-15 |
| ES359543A1 (es) | 1970-08-16 |
| FR2008585A1 (ro) | 1970-01-23 |
| MTP594B (en) | 1971-04-14 |
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