HUT61985A - New process for producing disulfide-type thiamine derivatives
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New process for producing disulfide-type thiamine derivatives
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Publication number
HUT61985A
HUT61985AHU275892AHU275892AHUT61985AHU T61985 AHUT61985 AHU T61985AHU 275892 AHU275892 AHU 275892AHU 275892 AHU275892 AHU 275892AHU T61985 AHUT61985 AHU T61985A
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Application filed by Takeda Chemical Industries LtdfiledCriticalTakeda Chemical Industries Ltd
Priority to HU275892ApriorityCriticalpatent/HU209921B/en
Publication of HUT61985ApublicationCriticalpatent/HUT61985A/en
Publication of HU209921BpublicationCriticalpatent/HU209921B/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Prodn. of a disulphide form of thiamine or its deriv. comprises mixing of thiamine cpd. of formula (I) and organic thiosulphate of formula (II) with an alkali in aq. soln. In formulae, R1= opt. substd. alkyl or aralkyl; M= ammonium, alkali metal, or alkaline earth metal; R2= H, alkyl, aralkyl, or ester group. - Specifically the reaction system is satd. or super-satd. with NaCl or other inorganic salt; the alkali used is NaOH; (I) and (II) are added to an aq. soln. of alkali; alkali soln. is added to a mixed. aq. soln. of (I) and (II); the mixing is carried out by gradual addn.; and the reaction is seeded with crystals of target cpd.
HU275892A1990-12-281990-12-28New process for producing disulfide-type derivatives of thiamine
HU209921B
(en)