HUT57187A - Process for producing carbacyclin derivatives with stereoselective introducing 5,6-duble bond - Google Patents
Process for producing carbacyclin derivatives with stereoselective introducing 5,6-duble bondInfo
- Publication number
- HUT57187A HUT57187A HU896873A HU687389A HUT57187A HU T57187 A HUT57187 A HU T57187A HU 896873 A HU896873 A HU 896873A HU 687389 A HU687389 A HU 687389A HU T57187 A HUT57187 A HU T57187A
- Authority
- HU
- Hungary
- Prior art keywords
- producing
- bond
- duble
- stereoselective
- introducing
- Prior art date
Links
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 bicyclic ketone Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- YSSSPARMOAYJTE-UHFFFAOYSA-N dibenzo-18-crown-6 Chemical compound O1CCOCCOC2=CC=CC=C2OCCOCCOC2=CC=CC=C21 YSSSPARMOAYJTE-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3839155A DE3839155A1 (de) | 1988-11-17 | 1988-11-17 | Verfahren zur herstellung von carbacyclin-derivaten durch stereoselektive einfuehrung der 5,6-doppelbindung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU896873D0 HU896873D0 (en) | 1991-08-28 |
| HUT57187A true HUT57187A (en) | 1991-11-28 |
| HU208116B HU208116B (en) | 1993-08-30 |
Family
ID=6367494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU896873A HU208116B (en) | 1988-11-17 | 1989-11-17 | Process for producing carbacycline derivatives by the stereoselective introduction of double bond in 5,6-position |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0369563B1 (hu) |
| JP (1) | JPH04501721A (hu) |
| AT (1) | ATE88180T1 (hu) |
| AU (1) | AU648498B2 (hu) |
| CA (1) | CA2003260C (hu) |
| DE (2) | DE3839155A1 (hu) |
| ES (1) | ES2055023T3 (hu) |
| HU (1) | HU208116B (hu) |
| WO (1) | WO1990005720A1 (hu) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4915582U (hu) * | 1972-05-15 | 1974-02-08 | ||
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| JPS56145239A (en) * | 1980-04-11 | 1981-11-11 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative and its preparation |
| GB2129427B (en) * | 1982-10-01 | 1986-01-08 | Erba Farmitalia | 15-cycloaliphatic derivatives of 13,14-didehydrocarboprostacyclins and process for their preparation |
| JPS59124231A (ja) * | 1982-12-28 | 1984-07-18 | 株式会社ダイフク | 密封包装体の製造装置 |
-
1988
- 1988-11-17 DE DE3839155A patent/DE3839155A1/de not_active Ceased
-
1989
- 1989-11-17 WO PCT/DE1989/000730 patent/WO1990005720A1/de unknown
- 1989-11-17 ES ES89250091T patent/ES2055023T3/es not_active Expired - Lifetime
- 1989-11-17 DE DE8989250091T patent/DE58904071D1/de not_active Expired - Lifetime
- 1989-11-17 EP EP89250091A patent/EP0369563B1/de not_active Expired - Lifetime
- 1989-11-17 HU HU896873A patent/HU208116B/hu not_active IP Right Cessation
- 1989-11-17 AT AT89250091T patent/ATE88180T1/de active
- 1989-11-17 AU AU46343/89A patent/AU648498B2/en not_active Ceased
- 1989-11-17 CA CA002003260A patent/CA2003260C/en not_active Expired - Fee Related
- 1989-11-17 JP JP2500118A patent/JPH04501721A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990005720A1 (de) | 1990-05-31 |
| HU208116B (en) | 1993-08-30 |
| AU648498B2 (en) | 1994-04-28 |
| ES2055023T3 (es) | 1994-08-16 |
| EP0369563B1 (de) | 1993-04-14 |
| JPH04501721A (ja) | 1992-03-26 |
| DE3839155A1 (de) | 1990-05-23 |
| DE58904071D1 (de) | 1993-05-19 |
| AU4634389A (en) | 1990-06-12 |
| CA2003260C (en) | 1998-04-07 |
| CA2003260A1 (en) | 1990-05-17 |
| ATE88180T1 (de) | 1993-04-15 |
| HU896873D0 (en) | 1991-08-28 |
| EP0369563A1 (de) | 1990-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HMM4 | Cancellation of final prot. due to non-payment of fee |