HUT47092A - Process for producing thiadiazol derivatives and pharmaceutical compositions containing them as active components - Google Patents

Process for producing thiadiazol derivatives and pharmaceutical compositions containing them as active components

Info

Publication number
HUT47092A
HUT47092A HU865218A HU521886A HUT47092A HU T47092 A HUT47092 A HU T47092A HU 865218 A HU865218 A HU 865218A HU 521886 A HU521886 A HU 521886A HU T47092 A HUT47092 A HU T47092A
Authority
HU
Hungary
Prior art keywords
alkyl
producing
pharmaceutical compositions
compositions containing
active components
Prior art date
Application number
HU865218A
Other languages
Hungarian (hu)
Other versions
HU198461B (en
Inventor
Brent J Rieder
Chyun-Yeh E Wu
William B Blanchard
Wayne A Spitzer
Charles J Paget Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to HU893086A priority Critical patent/HU207218B/en
Publication of HUT47092A publication Critical patent/HUT47092A/en
Publication of HU198461B publication Critical patent/HU198461B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

(1) 1,3,4-Thiadiazole-2-cyanamide and derivs. of formula (I) and their salts are new. In (I), R1 = H; R2 = CN; or R1+R2 = =C(SR6)NH2 or =C(NH2)2; R6 = 1-4C alkyl, cyano-(1-4C)alkyl or pyridyl-(1-4C)alkyl. (2) In vitro antiviral method for protecting mammalian cells in culture comprises adding to the culture a cpd. (I) in which either (A) R1 = H; R2 = CN or =CH-NHR3; or R1+R2 = =C(NH2)2 or =CR5-NHR3(1); R3 = COOR4; R3(1) = H or COOR4; R4 = 1-10C alkyl, 2-10C alkenyl or Ph, each opt. substd.; R5 = H or SR6; R6 = 1-4C alkyl, cyano-(1-4C)alkyl or pyridyl-(1-4C)alkyl; or (B) as defined for (A) except that R1+R2 = =CR5NHR31 only; and R3, R31 = H or COOR4.
HU865218A 1985-12-16 1986-12-15 Process for producing thiadiazole derivatives and pharmaceutical compositions comprising same as active ingredient HU198461B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU893086A HU207218B (en) 1985-12-16 1986-12-15 Process for producing antiviral pharmaceutical composition containing thiadiazol derivatives as active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80966985A 1985-12-16 1985-12-16

Publications (2)

Publication Number Publication Date
HUT47092A true HUT47092A (en) 1989-01-30
HU198461B HU198461B (en) 1989-10-30

Family

ID=25201936

Family Applications (1)

Application Number Title Priority Date Filing Date
HU865218A HU198461B (en) 1985-12-16 1986-12-15 Process for producing thiadiazole derivatives and pharmaceutical compositions comprising same as active ingredient

Country Status (15)

Country Link
KR (1) KR890004197B1 (en)
CN (1) CN1014242B (en)
AT (1) ATE59405T1 (en)
DE (1) DE3676673D1 (en)
DK (1) DK602786A (en)
EG (1) EG17724A (en)
GR (1) GR3001371T3 (en)
HK (1) HK2792A (en)
HU (1) HU198461B (en)
IL (1) IL80962A (en)
MY (1) MY101918A (en)
NZ (1) NZ218648A (en)
PT (1) PT83930B (en)
SG (1) SG98891G (en)
ZA (1) ZA869439B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108374182B (en) * 2018-02-27 2019-08-16 广西师范大学 A kind of new method of electrochemistry formated 1,2,4- thiadiazole compound

Also Published As

Publication number Publication date
ZA869439B (en) 1988-08-31
ATE59405T1 (en) 1991-01-15
HK2792A (en) 1992-01-10
GR3001371T3 (en) 1992-09-11
KR870006026A (en) 1987-07-08
IL80962A (en) 1991-12-15
EG17724A (en) 1990-08-30
HU198461B (en) 1989-10-30
SG98891G (en) 1992-01-17
PT83930A (en) 1987-01-01
DK602786A (en) 1987-06-17
DK602786D0 (en) 1986-12-15
CN1014242B (en) 1991-10-09
PT83930B (en) 1989-06-30
CN86108507A (en) 1987-08-05
MY101918A (en) 1992-02-15
DE3676673D1 (en) 1991-02-07
KR890004197B1 (en) 1989-10-27
IL80962A0 (en) 1987-03-31
NZ218648A (en) 1989-07-27

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee