HUT45256A - Process for producing 1,3,4,9-tetrahydropyrano/3,4-b/indol-1-acetic acid derivatives and pharmaceutical composition containing them - Google Patents

Process for producing 1,3,4,9-tetrahydropyrano/3,4-b/indol-1-acetic acid derivatives and pharmaceutical composition containing them

Info

Publication number
HUT45256A
HUT45256A HU87815A HU81587A HUT45256A HU T45256 A HUT45256 A HU T45256A HU 87815 A HU87815 A HU 87815A HU 81587 A HU81587 A HU 81587A HU T45256 A HUT45256 A HU T45256A
Authority
HU
Hungary
Prior art keywords
tetrahydropyrano
indol
producing
pharmaceutical composition
acetic acid
Prior art date
Application number
HU87815A
Other languages
English (en)
Other versions
HU196210B (en
Inventor
Alan H Katz
Christopher A Demerson
Leslie G Humber
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of HUT45256A publication Critical patent/HUT45256A/hu
Publication of HU196210B publication Critical patent/HU196210B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
HU87815A 1986-03-11 1987-02-27 Process for producing 1,3,4,9-tetrahydropyrano/3,4-b/ indole-1-acetic acid derivatives and pharmaceutics comprising such compounds HU196210B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/838,510 US4670462A (en) 1986-03-11 1986-03-11 Substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids

Publications (2)

Publication Number Publication Date
HUT45256A true HUT45256A (en) 1988-06-28
HU196210B HU196210B (en) 1988-10-28

Family

ID=25277271

Family Applications (1)

Application Number Title Priority Date Filing Date
HU87815A HU196210B (en) 1986-03-11 1987-02-27 Process for producing 1,3,4,9-tetrahydropyrano/3,4-b/ indole-1-acetic acid derivatives and pharmaceutics comprising such compounds

Country Status (17)

Country Link
US (1) US4670462A (hu)
JP (1) JPH0737459B2 (hu)
KR (1) KR940009788B1 (hu)
AR (1) AR246523A1 (hu)
CA (1) CA1327202C (hu)
CS (1) CS274612B2 (hu)
DK (2) DK168216B1 (hu)
FI (1) FI85857C (hu)
GE (1) GEP19981260B (hu)
HU (1) HU196210B (hu)
IL (1) IL81602A (hu)
MX (1) MX9203642A (hu)
PH (1) PH24248A (hu)
PT (1) PT84382B (hu)
RU (1) RU2001916C1 (hu)
SU (1) SU1531856A3 (hu)
ZA (1) ZA871338B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810699A (en) * 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4742076A (en) * 1987-06-03 1988-05-03 American Home Products Corporation Etodolac for lowering rheumatoid factor
US4897493A (en) * 1987-08-27 1990-01-30 American Home Products Corporation Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
US4824961A (en) * 1987-08-27 1989-04-25 American Home Products Corporation Production of substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
EP0337585A1 (en) * 1987-08-27 1989-10-18 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-l-acetic acids
US4822893A (en) * 1988-02-08 1989-04-18 American Home Products Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
US4925955A (en) * 1989-02-28 1990-05-15 American Home Products Corporation Resolution of (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-B]indole-1-acetic acid using brucine
TW200400818A (en) 2002-05-21 2004-01-16 Wyeth Corp Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
US20060058532A1 (en) * 2004-09-10 2006-03-16 Warren Chew Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
WO2012164085A1 (en) 2011-06-03 2012-12-06 Merz Pharma Gmbh & Co. Kgaa Glycine b antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939178A (en) * 1971-06-01 1976-02-17 American Home Products Corporation Certain pyrano [3,4-b]indoles and thiopyrano[3,4-b]indoles
US3974179A (en) * 1971-06-01 1976-08-10 American Home Products Corporation 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives
US3843681A (en) * 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
US4012417A (en) * 1972-05-16 1977-03-15 American Home Products Corporation Process for preparing pyrano[3,4-b]indole or thio pyrano[3,4-b]indole derivatives
US4076831A (en) * 1972-05-16 1978-02-28 American Home Products Corporation Pyrano[3,4-b]-indole derivatives, pharmaceutical compositions and methods of use
US4070371A (en) * 1972-05-16 1978-01-24 American Home Products Corporation Derivatives of 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
US4003913A (en) * 1973-07-09 1977-01-18 Ayerst Mckenna And Harrison Ltd. Pyrano- and thiopyranoindole derivatives, compositions and methods of use

Also Published As

Publication number Publication date
DK103987D0 (da) 1987-02-27
KR940009788B1 (ko) 1994-10-17
FI870627A (fi) 1987-09-12
IL81602A (en) 1991-03-10
FI85857B (fi) 1992-02-28
DK168216B1 (da) 1994-02-28
KR870008890A (ko) 1987-10-21
US4670462A (en) 1987-06-02
PH24248A (en) 1990-05-04
DK69493A (da) 1993-06-11
RU2001916C1 (ru) 1993-10-30
CS274612B2 (en) 1991-09-15
SU1531856A3 (ru) 1989-12-23
FI85857C (fi) 1992-06-10
JPS62221688A (ja) 1987-09-29
MX9203642A (es) 1992-07-01
JPH0737459B2 (ja) 1995-04-26
CS107487A2 (en) 1990-11-14
PT84382B (pt) 1989-10-04
HU196210B (en) 1988-10-28
PT84382A (en) 1987-03-01
FI870627A0 (fi) 1987-02-13
AR246523A1 (es) 1994-08-31
DK169338B1 (da) 1994-10-10
DK103987A (da) 1987-09-12
ZA871338B (en) 1988-09-28
GEP19981260B (en) 1998-04-01
DK69493D0 (da) 1993-06-11
CA1327202C (en) 1994-02-22
IL81602A0 (en) 1987-09-16

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee