HUT40123A - Process for preparing nalidixic acid - Google Patents

Process for preparing nalidixic acid

Info

Publication number
HUT40123A
HUT40123A HU68485A HU68485A HUT40123A HU T40123 A HUT40123 A HU T40123A HU 68485 A HU68485 A HU 68485A HU 68485 A HU68485 A HU 68485A HU T40123 A HUT40123 A HU T40123A
Authority
HU
Hungary
Prior art keywords
mixt
acid
soln
general formula
nalidixic
Prior art date
Application number
HU68485A
Other languages
Hungarian (hu)
Other versions
HU192325B (en
Inventor
Csaba Huszar
Karoly Ban
Ferenc Garamszegi
Eva Somfai
Gyulane Hernadi
Lajosne Pali
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to HU68485A priority Critical patent/HU192325B/en
Publication of HUT40123A publication Critical patent/HUT40123A/en
Publication of HU192325B publication Critical patent/HU192325B/en

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nalidixic-acid (I) is purified by heating the mixt. (A) contg. cpds. of general formula (IV) and (VI) as well as e.g. (II), (V) with acid, filtering the solid mixt. (B) contg. nalidixic-acid and cpds. of general formula (III) and (IV) from the soln. of cpd. (V) in the reaction mixt. and either: (a) dissolving it in a two-phase system contg. water and alcohol or dialkyl-ether at pH 9-11, neutralising the soln. and sepg. by filtration mixt. (C) contg. nalidixic-acid and cpds. of general formula (IV), or (b) dissolving the mixt. (B) in an acid-amide, cooling the soln. and sepg. by filtration the solid mixt. (C) from the complex of general formula (III) remaining in soln. subsequently dissolving mixt. (C) in alkaline water, binding cpds. of general formula (IV) on a mineral adsorbent, acidifying the soln. opt. in the presence of an alkanol and sepg. nalidixic-acid by filtration. - In the formulae, R1 = 1-3C alkyl, A is an anion, R2 is hydrogen or 1-2C alkyl (R is not defined).
HU68485A 1985-02-25 1985-02-25 Process for preparing nalidixic acid HU192325B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU68485A HU192325B (en) 1985-02-25 1985-02-25 Process for preparing nalidixic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU68485A HU192325B (en) 1985-02-25 1985-02-25 Process for preparing nalidixic acid

Publications (2)

Publication Number Publication Date
HUT40123A true HUT40123A (en) 1986-11-28
HU192325B HU192325B (en) 1987-05-28

Family

ID=10950837

Family Applications (1)

Application Number Title Priority Date Filing Date
HU68485A HU192325B (en) 1985-02-25 1985-02-25 Process for preparing nalidixic acid

Country Status (1)

Country Link
HU (1) HU192325B (en)

Also Published As

Publication number Publication date
HU192325B (en) 1987-05-28

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee