HUT40123A - Process for preparing nalidixic acid - Google Patents
Process for preparing nalidixic acidInfo
- Publication number
- HUT40123A HUT40123A HU68485A HU68485A HUT40123A HU T40123 A HUT40123 A HU T40123A HU 68485 A HU68485 A HU 68485A HU 68485 A HU68485 A HU 68485A HU T40123 A HUT40123 A HU T40123A
- Authority
- HU
- Hungary
- Prior art keywords
- mixt
- acid
- soln
- general formula
- nalidixic
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Nalidixic-acid (I) is purified by heating the mixt. (A) contg. cpds. of general formula (IV) and (VI) as well as e.g. (II), (V) with acid, filtering the solid mixt. (B) contg. nalidixic-acid and cpds. of general formula (III) and (IV) from the soln. of cpd. (V) in the reaction mixt. and either: (a) dissolving it in a two-phase system contg. water and alcohol or dialkyl-ether at pH 9-11, neutralising the soln. and sepg. by filtration mixt. (C) contg. nalidixic-acid and cpds. of general formula (IV), or (b) dissolving the mixt. (B) in an acid-amide, cooling the soln. and sepg. by filtration the solid mixt. (C) from the complex of general formula (III) remaining in soln. subsequently dissolving mixt. (C) in alkaline water, binding cpds. of general formula (IV) on a mineral adsorbent, acidifying the soln. opt. in the presence of an alkanol and sepg. nalidixic-acid by filtration. - In the formulae, R1 = 1-3C alkyl, A is an anion, R2 is hydrogen or 1-2C alkyl (R is not defined).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU68485A HU192325B (en) | 1985-02-25 | 1985-02-25 | Process for preparing nalidixic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU68485A HU192325B (en) | 1985-02-25 | 1985-02-25 | Process for preparing nalidixic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
HUT40123A true HUT40123A (en) | 1986-11-28 |
HU192325B HU192325B (en) | 1987-05-28 |
Family
ID=10950837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU68485A HU192325B (en) | 1985-02-25 | 1985-02-25 | Process for preparing nalidixic acid |
Country Status (1)
Country | Link |
---|---|
HU (1) | HU192325B (en) |
-
1985
- 1985-02-25 HU HU68485A patent/HU192325B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU192325B (en) | 1987-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HU90 | Patent valid on 900628 | ||
HMM4 | Cancellation of final prot. due to non-payment of fee |