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Laboratorios Made SA
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Laboratorios Made SA
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Priority to ES539416ApriorityCriticalpatent/ES8602009A1/en
Publication of ES539416A0publicationCriticalpatent/ES539416A0/en
Publication of ES8602009A1publicationCriticalpatent/ES8602009A1/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
(AREA)
Plural Heterocyclic Compounds
(AREA)
Abstract
The process comprises reaction of 2-amino-3-benzoyl-4,5-tetramethylene thiophene with N-phthalimido-acetic acid in the presence of 1-1-carbonyl diimidazol and in various media to give 2-(N-phthalimido acetylamino)-3-benzoyl -4,5-tetramethylene thiophene. The resulting cpd. undergoes hydrazinolising, with spontaneous cyclising and isolation by concn. and filtration. This gives Bentazepam of formula (I).
ES539416A1985-01-091985-01-09Industrial prodn. of thieno:diazepine
ExpiredES8602009A1
(en)