HUS2400004I1 - Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében - Google Patents
Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésébenInfo
- Publication number
- HUS2400004I1 HUS2400004I1 HUS2400004C HUS2400004C HUS2400004I1 HU S2400004 I1 HUS2400004 I1 HU S2400004I1 HU S2400004 C HUS2400004 C HU S2400004C HU S2400004 C HUS2400004 C HU S2400004C HU S2400004 I1 HUS2400004 I1 HU S2400004I1
- Authority
- HU
- Hungary
- Prior art keywords
- diaminopyrimidine
- cough
- treatment
- receptor modulators
- modulators
- Prior art date
Links
- 206010011224 Cough Diseases 0.000 title 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234584P | 2015-09-29 | 2015-09-29 | |
| US201662336381P | 2016-05-13 | 2016-05-13 | |
| EP16852340.5A EP3355889B1 (en) | 2015-09-29 | 2016-09-23 | Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUS2400004I1 true HUS2400004I1 (hu) | 2024-04-28 |
Family
ID=58424436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16852340A HUE061764T2 (hu) | 2015-09-29 | 2016-09-23 | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
| HUS2400004C HUS2400004I1 (hu) | 2015-09-29 | 2024-03-05 | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16852340A HUE061764T2 (hu) | 2015-09-29 | 2016-09-23 | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11260056B2 (hu) |
| EP (2) | EP4215182A1 (hu) |
| JP (1) | JP6877441B2 (hu) |
| KR (1) | KR20180054843A (hu) |
| AU (1) | AU2016330466B2 (hu) |
| CA (1) | CA2998742C (hu) |
| DK (1) | DK3355889T3 (hu) |
| ES (1) | ES2942711T3 (hu) |
| FI (2) | FI3355889T3 (hu) |
| FR (1) | FR24C1010I1 (hu) |
| HR (1) | HRP20230445T1 (hu) |
| HU (2) | HUE061764T2 (hu) |
| LT (1) | LT3355889T (hu) |
| MX (1) | MX2018003893A (hu) |
| NL (1) | NL301260I2 (hu) |
| PL (1) | PL3355889T3 (hu) |
| PT (1) | PT3355889T (hu) |
| RS (1) | RS64155B1 (hu) |
| SI (1) | SI3355889T1 (hu) |
| WO (1) | WO2017058645A1 (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019007163A (es) | 2016-12-20 | 2019-08-29 | Afferent Pharmaceuticals Inc | Sales cristalinas y polimorfos de un antagonista de p2x3. |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| BR112020022553A2 (pt) * | 2018-05-15 | 2021-02-02 | Bayer Aktiengesellschaft | benzamidas substituídas por 1,3-tiazol-2-ila para o tratamento de doenças associadas com a sensibilização de fibras nervosas |
| WO2020071530A1 (ja) * | 2018-10-05 | 2020-04-09 | 塩野義製薬株式会社 | 慢性咳嗽治療用医薬 |
| JP2022530890A (ja) * | 2019-04-30 | 2022-07-04 | ベイジン タイド ファーマシューティカル カンパニー リミテッド | ジアミノピリミジン化合物を使用することによって咳を治療する方法 |
| JP2022534303A (ja) | 2019-05-31 | 2022-07-28 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
| JP2022534434A (ja) | 2019-05-31 | 2022-07-29 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体 |
| WO2021054421A1 (ja) | 2019-09-19 | 2021-03-25 | 塩野義製薬株式会社 | １，３，５－トリアジン誘導体またはその溶媒和物の結晶およびその製造方法 |
| CN111635368B (zh) * | 2020-06-12 | 2021-06-29 | 东莞市东阳光仿制药研发有限公司 | 一种胺化合物的制备方法 |
| EP4251620A1 (en) | 2020-11-27 | 2023-10-04 | Chiesi Farmaceutici S.p.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| WO2022112491A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| MX2023005801A (es) | 2020-11-27 | 2023-05-29 | Chiesi Farm Spa | Derivados de ftalazina como inhibidores de purinoceptor 3 de p2x (p2x3). |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2391636T3 (es) | 2004-03-05 | 2012-11-28 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como antagonistas de P2X3 y P2X2/3 |
| US20060029548A1 (en) | 2004-07-22 | 2006-02-09 | Amir Pelleg | Methods of diagnosing, monitoring and treating pulmonary diseases |
| CA2620129C (en) | 2005-09-01 | 2014-12-23 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2007025898A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Process for synthesis of aryloxy diaminopyrimidines |
| ES2439454T3 (es) | 2005-09-01 | 2014-01-23 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P2X2/3 |
| CA2619919C (en) | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| CA2664305C (en) * | 2006-10-04 | 2016-06-07 | F. Hoffmann-La Roche Ag | Process for synthesis of phenoxy diaminopyrimidine derivatives |
| WO2008104474A1 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Diaminopyrimidines |
| MY195728A (en) | 2013-08-23 | 2023-02-07 | Afferent Pharmaceuticals Inc | Diaminopyrimidine P2x3 and P2x 2/3 Receptor Modulators for Treatment of Acute, Sub-Acute or Chronic Cough |
-
2016
- 2016-09-23 PL PL16852340.5T patent/PL3355889T3/pl unknown
- 2016-09-23 HU HUE16852340A patent/HUE061764T2/hu unknown
- 2016-09-23 CA CA2998742A patent/CA2998742C/en active Active
- 2016-09-23 FI FIEP16852340.5T patent/FI3355889T3/fi active
- 2016-09-23 MX MX2018003893A patent/MX2018003893A/es unknown
- 2016-09-23 ES ES16852340T patent/ES2942711T3/es active Active
- 2016-09-23 JP JP2018535821A patent/JP6877441B2/ja active Active
- 2016-09-23 EP EP23155536.8A patent/EP4215182A1/en active Pending
- 2016-09-23 PT PT168523405T patent/PT3355889T/pt unknown
- 2016-09-23 KR KR1020187011747A patent/KR20180054843A/ko not_active Application Discontinuation
- 2016-09-23 WO PCT/US2016/053223 patent/WO2017058645A1/en active Application Filing
- 2016-09-23 AU AU2016330466A patent/AU2016330466B2/en active Active
- 2016-09-23 LT LTEPPCT/US2016/053223T patent/LT3355889T/lt unknown
- 2016-09-23 EP EP16852340.5A patent/EP3355889B1/en active Active
- 2016-09-23 HR HRP20230445TT patent/HRP20230445T1/hr unknown
- 2016-09-23 DK DK16852340.5T patent/DK3355889T3/da active
- 2016-09-23 SI SI201631686T patent/SI3355889T1/sl unknown
- 2016-09-23 RS RS20230321A patent/RS64155B1/sr unknown
- 2016-09-23 US US15/764,174 patent/US11260056B2/en active Active
-
2022
- 2022-01-24 US US17/582,485 patent/US20220143015A1/en not_active Abandoned
-
2024
- 2024-03-04 NL NL301260C patent/NL301260I2/nl unknown
- 2024-03-05 HU HUS2400004C patent/HUS2400004I1/hu unknown
- 2024-03-12 FR FR24C1010C patent/FR24C1010I1/fr active Active
- 2024-03-13 FI FIC20240006C patent/FIC20240006I1/fi unknown
- 2024-04-19 US US18/640,100 patent/US20240285620A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR24C1010I1 (fr) | 2024-05-24 |
| US20240285620A1 (en) | 2024-08-29 |
| AU2016330466A1 (en) | 2018-03-29 |
| EP4215182A1 (en) | 2023-07-26 |
| CA2998742A1 (en) | 2017-04-06 |
| NL301260I2 (nl) | 2024-03-25 |
| MX2018003893A (es) | 2018-06-22 |
| PT3355889T (pt) | 2023-04-26 |
| EP3355889A4 (en) | 2019-05-22 |
| DK3355889T3 (da) | 2023-05-15 |
| RS64155B1 (sr) | 2023-05-31 |
| LT3355889T (lt) | 2023-05-10 |
| US20220143015A1 (en) | 2022-05-12 |
| FI3355889T3 (fi) | 2023-05-15 |
| US11260056B2 (en) | 2022-03-01 |
| JP2018529776A (ja) | 2018-10-11 |
| KR20180054843A (ko) | 2018-05-24 |
| CA2998742C (en) | 2023-08-29 |
| WO2017058645A1 (en) | 2017-04-06 |
| PL3355889T3 (pl) | 2023-05-22 |
| JP6877441B2 (ja) | 2021-05-26 |
| FIC20240006I1 (fi) | 2024-03-13 |
| ES2942711T3 (es) | 2023-06-06 |
| HRP20230445T1 (hr) | 2023-07-21 |
| HUE061764T2 (hu) | 2023-08-28 |
| AU2016330466B2 (en) | 2021-01-28 |
| SI3355889T1 (sl) | 2023-07-31 |
| EP3355889A1 (en) | 2018-08-08 |
| US20180280388A1 (en) | 2018-10-04 |
| EP3355889B1 (en) | 2023-02-15 |
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