HUP9900954A2 - Process for the production of powdered pulmonary surfactant preparations - Google Patents

Process for the production of powdered pulmonary surfactant preparations

Info

Publication number
HUP9900954A2
HUP9900954A2 HU9900954A HUP9900954A HUP9900954A2 HU P9900954 A2 HUP9900954 A2 HU P9900954A2 HU 9900954 A HU9900954 A HU 9900954A HU P9900954 A HUP9900954 A HU P9900954A HU P9900954 A2 HUP9900954 A2 HU P9900954A2
Authority
HU
Hungary
Prior art keywords
production
pulmonary surfactant
surfactant preparations
lung surfactant
powder
Prior art date
Application number
HU9900954A
Other languages
Hungarian (hu)
Inventor
Klaus Eistetter
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh. filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh.
Priority claimed from PCT/EP1997/000230 external-priority patent/WO1997026863A1/en
Publication of HUP9900954A2 publication Critical patent/HUP9900954A2/en
Publication of HUP9900954A3 publication Critical patent/HUP9900954A3/en
Publication of HU224988B1 publication Critical patent/HU224988B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya eljárás hidrőfób tüdőfelületaktív-fehérjékettartalmazó pőr alakú tüdőfelületaktívanyag-készítmény előállításáraőly módőn, hőgy hidrőfób tüdőfelületaktív-fehérjéket és kívánt esetbentővábbi kőmpőnenseket tartalmazó szerves őldatőt vagy szűszpenziótpőrlasztva szárításnak vetnek alá. Nagyőn jó tárőlási stabilitássalrendelkező, egyszerűen pőrkészítménnyé alakítható, belélegeztetésútján is felhasználható terméket nyernek. ŕThe subject of the invention is a method for the production of a powder-shaped lung surfactant preparation containing hydrophobic lung surfactant proteins, in which an organic solvent or suspension containing hydrophobic lung surfactant proteins and, if desired, other stone components is subjected to powder drying. They obtain a product with very good storage stability, which can easily be turned into a powder preparation and can also be used by inhalation. ŕ

HU9900954A 1996-01-24 1997-01-18 Process for the production of powdered pulmonary surfactant preparations HU224988B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (en) 1996-01-24 1996-01-24 Production of lung surfactant preparation in powder form
PCT/EP1997/000230 WO1997026863A1 (en) 1996-01-24 1997-01-18 Process for the production of powdered pulmonary surfactant preparations

Publications (3)

Publication Number Publication Date
HUP9900954A2 true HUP9900954A2 (en) 1999-08-30
HUP9900954A3 HUP9900954A3 (en) 2000-06-28
HU224988B1 HU224988B1 (en) 2006-05-29

Family

ID=7783463

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900954A HU224988B1 (en) 1996-01-24 1997-01-18 Process for the production of powdered pulmonary surfactant preparations

Country Status (9)

Country Link
CN (1) CN1142770C (en)
AU (1) AU714998B2 (en)
BR (1) BR9707299A (en)
DE (1) DE19602332A1 (en)
EA (1) EA001382B1 (en)
HK (1) HK1020016A1 (en)
HU (1) HU224988B1 (en)
IL (1) IL125439A (en)
PL (1) PL187293B1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
PT1280520E (en) 2000-05-10 2014-12-16 Novartis Ag Phospholipid-based powders for drug delivery
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
EP2022798A1 (en) * 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Also Published As

Publication number Publication date
PL328194A1 (en) 1999-01-18
EA001382B1 (en) 2001-02-26
EA199800649A1 (en) 1999-06-24
AU714998B2 (en) 2000-01-13
HUP9900954A3 (en) 2000-06-28
PL187293B1 (en) 2004-06-30
IL125439A0 (en) 1999-03-12
AU1593097A (en) 1997-08-20
BR9707299A (en) 1999-07-20
HK1020016A1 (en) 2000-03-10
IL125439A (en) 2000-10-31
CN1142770C (en) 2004-03-24
DE19602332A1 (en) 1997-07-31
HU224988B1 (en) 2006-05-29
CN1217654A (en) 1999-05-26

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ALTANA PHARMA AG, DE

Free format text: FORMER OWNER(S): BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE

HC9A Change of name, address

Owner name: TAKEDA GMBH, DE

Free format text: FORMER OWNER(S): ALTANA PHARMA AG, DE; BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE; NYCOMED GMBH, DE

GB9A Succession in title

Owner name: TAKEDA GMBH, DE

Free format text: FORMER OWNER(S): ALTANA PHARMA AG, DE; BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE; NYCOMED GMBH, DE; TAKEDA GMBH, DE