EA199800649A1 - METHOD FOR OBTAINING POWDER PREPARATIONS OF THE LUNG SURFACE-ACTIVE SUBSTANCE - Google Patents

METHOD FOR OBTAINING POWDER PREPARATIONS OF THE LUNG SURFACE-ACTIVE SUBSTANCE

Info

Publication number
EA199800649A1
EA199800649A1 EA199800649A EA199800649A EA199800649A1 EA 199800649 A1 EA199800649 A1 EA 199800649A1 EA 199800649 A EA199800649 A EA 199800649A EA 199800649 A EA199800649 A EA 199800649A EA 199800649 A1 EA199800649 A1 EA 199800649A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active substance
lung surface
powder preparations
obtaining powder
pulmonary
Prior art date
Application number
EA199800649A
Other languages
Russian (ru)
Other versions
EA001382B1 (en
Inventor
Клаус Айштеттер
Original Assignee
Бык Гульден Ломберг Хемише Фабрик Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бык Гульден Ломберг Хемише Фабрик Гмбх filed Critical Бык Гульден Ломберг Хемише Фабрик Гмбх
Priority claimed from PCT/EP1997/000230 external-priority patent/WO1997026863A1/en
Publication of EA199800649A1 publication Critical patent/EA199800649A1/en
Publication of EA001382B1 publication Critical patent/EA001382B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

В заявке описан способ получения порошкового препарата легочного ПАВ, содержащего гидрофобные протеины легочного ПАВ, отличающийся тем, что органические раствор или суспензию, содержащие гидрофобные протеины легочного ПАВ и необязательно другие компоненты, подвергают распылительной сушке. Таким путем получают порошковые препараты, которые обладают очень высокой стойкостью при хранении, легко восстанавливаются и пригодны для ингаляторного применения.Международная заявка была опубликована вместе с отчетом о международном поиске.The application describes a method for producing a pulmonary powder surfactant containing hydrophobic proteins of the pulmonary surfactant, characterized in that an organic solution or suspension containing hydrophobic proteins of the pulmonary surfactant and, optionally, other components, is spray dried. In this way, powdered preparations are obtained which have a very high storage stability, are easily recovered and are suitable for inhalation use. The international application was published together with an international search report.

EA199800649A 1996-01-24 1997-01-18 Process for the production of powdered pulmonry surfactant preparations EA001382B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (en) 1996-01-24 1996-01-24 Production of lung surfactant preparation in powder form
PCT/EP1997/000230 WO1997026863A1 (en) 1996-01-24 1997-01-18 Process for the production of powdered pulmonary surfactant preparations

Publications (2)

Publication Number Publication Date
EA199800649A1 true EA199800649A1 (en) 1999-06-24
EA001382B1 EA001382B1 (en) 2001-02-26

Family

ID=7783463

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800649A EA001382B1 (en) 1996-01-24 1997-01-18 Process for the production of powdered pulmonry surfactant preparations

Country Status (9)

Country Link
CN (1) CN1142770C (en)
AU (1) AU714998B2 (en)
BR (1) BR9707299A (en)
DE (1) DE19602332A1 (en)
EA (1) EA001382B1 (en)
HK (1) HK1020016A1 (en)
HU (1) HU224988B1 (en)
IL (1) IL125439A (en)
PL (1) PL187293B1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
JP2005514393A (en) 2001-12-19 2005-05-19 ネクター セラピューティクス Supplying aminoglycosides to the lung
EP2022798A1 (en) * 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Also Published As

Publication number Publication date
IL125439A (en) 2000-10-31
BR9707299A (en) 1999-07-20
EA001382B1 (en) 2001-02-26
HU224988B1 (en) 2006-05-29
DE19602332A1 (en) 1997-07-31
PL187293B1 (en) 2004-06-30
CN1217654A (en) 1999-05-26
CN1142770C (en) 2004-03-24
PL328194A1 (en) 1999-01-18
HUP9900954A2 (en) 1999-08-30
HUP9900954A3 (en) 2000-06-28
AU1593097A (en) 1997-08-20
HK1020016A1 (en) 2000-03-10
AU714998B2 (en) 2000-01-13
IL125439A0 (en) 1999-03-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
TC4A Change in name of a patent proprietor in a eurasian patent
MK4A Patent expired

Designated state(s): BY RU