HUP9900923A2 - Process for the synthesis of vinyl-sulfenic acid derivatives - Google Patents
Process for the synthesis of vinyl-sulfenic acid derivativesInfo
- Publication number
- HUP9900923A2 HUP9900923A2 HU9900923A HUP9900923A HUP9900923A2 HU P9900923 A2 HUP9900923 A2 HU P9900923A2 HU 9900923 A HU9900923 A HU 9900923A HU P9900923 A HUP9900923 A HU P9900923A HU P9900923 A2 HUP9900923 A2 HU P9900923A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- alkyl
- powder
- atom
- alkyloxy
- Prior art date
Links
- SLAWTOLLPNIOGD-UHFFFAOYSA-N hydroxysulfanylethene Chemical class OSC=C SLAWTOLLPNIOGD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/18—Sulfenamides
- C07C313/20—Sulfenamides having sulfur atoms of sulfenamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát a (III) általánős képletű vinil-szűlfénsav-vegyületek képezik, ahől a képletben R1 jelentése hidrőgénatőm, 1-4szénatőmős alkőxi-, aril-alkőxi-csőpőrt, halőgénatőm vagyaminőcsőpőrt, R2 jelentése hidrőgénatőm, 1-4 szénatőmős alkőxi-, aril-alkőxi-csőpőrt, halőgénatőm vagy aminőcsőpőrt, R4 jelentése OSi(R)3,NR5R6 vagy SR8, az egyes R csőpőrtők jelentése egymástól függetlenül1-6 szénatőmős alkil-, aril- vagy aril-alkil-csőpőrt, R5 és R6jelentése egymástól függetlenül hidrőgénatőm, 1-6 szénatőmős alkil-,aril-alkil- vagy arilcsőpőrt, vagy R5 és R6 együttes jelentése aszőmszédős nitrőgénatőmmal együtt, amelyhez kapcsőlódnak, egypiperidin, pirrőlidin, mőrfőlin vagy hexametilimin gyűrűs csőpőrt , ésR8 jelentése 1-6 szénatőmős alkil-, aril- vagy aril-alkil-csőpőrt. Atalálmány tárgyáhőz tartőzik tővábbá a (III) általánős képletűvegyületek előállítására szőlgáló eljárás is. A találmány szerintivegyületek eredményesen alkalmazhatók a (XIII) általánős képletűbenző[b]tiőfém-származékők előállításáhőz. ŕThe subject of the invention is the vinyl sulfenic acid compounds of the general formula (III), where R1 is a hydrogen atom, a C1-4 alkyloxy, aryl-alkyloxy, a halogen atom or an amine atom, R2 is a hydrogen atom, a C1-4 alkyloxy, aryl -alkoxy pipe powder, halogen atom or amino pipe powder, R4 means OSi(R)3, NR5R6 or SR8, each R pipe powder independently means alkyl, aryl or aryl alkyl pipe powder with 1-6 carbon atoms, R5 and R6 independently mean hydrogen atom, 1-6 carbon-substituted alkyl-, aryl-alkyl- or aryl ring powders, or R5 and R6 together with the nitrogen atom to which they are attached, a piperidine, pyrrolidine, mörpholine or hexamethylimine ring powder, and R8 represents 1-6 carbon-substituted alkyl, aryl or aryl -alkyl pipe dust. The subject of the invention also includes the process for the production of compounds of general formula (III). The compounds according to the invention can be effectively used for the production of benzene[b]thiometal derivatives of general formula (XIII). ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,692 US5512701A (en) | 1995-06-07 | 1995-06-07 | Process for the synthesis of vinyl sulfenic acid derivatives |
US08/483,607 US5514826A (en) | 1995-06-07 | 1995-06-07 | Vinyl sulfenic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9900923A2 true HUP9900923A2 (en) | 1999-07-28 |
HUP9900923A3 HUP9900923A3 (en) | 2000-02-28 |
Family
ID=27047368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900923A HUP9900923A3 (en) | 1995-06-07 | 1996-06-04 | Process for the synthesis of vinyl-sulfenic acid derivatives |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0830362A4 (en) |
JP (1) | JPH11507346A (en) |
KR (1) | KR19990022503A (en) |
CN (2) | CN1068883C (en) |
AU (1) | AU698076B2 (en) |
BR (1) | BR9608847A (en) |
CA (1) | CA2224225A1 (en) |
CZ (1) | CZ387997A3 (en) |
EA (1) | EA000606B1 (en) |
HU (1) | HUP9900923A3 (en) |
IL (1) | IL122127A (en) |
NO (1) | NO975633L (en) |
NZ (1) | NZ310241A (en) |
PL (1) | PL323907A1 (en) |
TR (1) | TR199701511T1 (en) |
WO (1) | WO1996040693A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG106558A1 (en) * | 1995-06-07 | 2004-10-29 | Lilly Co Eli | Vinyl sulfoxides and a process for their synthesis |
TR199801494T2 (en) * | 1995-06-07 | 1998-09-21 | Eli Lilly And Company | Vinyl sulfoxides and a process for their synthesis. |
WO2004029046A2 (en) | 2002-09-30 | 2004-04-08 | A/S Gea Farmaceutisk Fabrik | Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
IL65379A0 (en) * | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
DE3543567A1 (en) * | 1985-12-10 | 1987-06-11 | Degussa | METHOD FOR PRODUCING SULFEN ACID CHLORIDES AND SULFEN ACID ESTERS |
-
1996
- 1996-06-04 CN CN96195947A patent/CN1068883C/en not_active Expired - Fee Related
- 1996-06-04 TR TR97/01511T patent/TR199701511T1/en unknown
- 1996-06-04 CA CA002224225A patent/CA2224225A1/en not_active Abandoned
- 1996-06-04 HU HU9900923A patent/HUP9900923A3/en unknown
- 1996-06-04 AU AU61003/96A patent/AU698076B2/en not_active Ceased
- 1996-06-04 JP JP9501774A patent/JPH11507346A/en active Pending
- 1996-06-04 NZ NZ310241A patent/NZ310241A/en unknown
- 1996-06-04 WO PCT/US1996/009460 patent/WO1996040693A1/en not_active Application Discontinuation
- 1996-06-04 EA EA199800026A patent/EA000606B1/en not_active IP Right Cessation
- 1996-06-04 BR BR9608847A patent/BR9608847A/en not_active Application Discontinuation
- 1996-06-04 IL IL12212796A patent/IL122127A/en active IP Right Grant
- 1996-06-04 KR KR1019970708984A patent/KR19990022503A/en not_active Application Discontinuation
- 1996-06-04 PL PL96323907A patent/PL323907A1/en unknown
- 1996-06-04 CZ CZ973879A patent/CZ387997A3/en unknown
- 1996-06-04 EP EP96918314A patent/EP0830362A4/en not_active Withdrawn
-
1997
- 1997-12-04 NO NO975633A patent/NO975633L/en not_active Application Discontinuation
-
2000
- 2000-12-12 CN CN00130796A patent/CN1330071A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ310241A (en) | 1999-07-29 |
JPH11507346A (en) | 1999-06-29 |
CZ387997A3 (en) | 1998-09-16 |
WO1996040693A1 (en) | 1996-12-19 |
AU698076B2 (en) | 1998-10-22 |
HUP9900923A3 (en) | 2000-02-28 |
EP0830362A1 (en) | 1998-03-25 |
TR199701511T1 (en) | 1998-04-21 |
CN1192215A (en) | 1998-09-02 |
CN1330071A (en) | 2002-01-09 |
CN1068883C (en) | 2001-07-25 |
IL122127A0 (en) | 1998-04-05 |
IL122127A (en) | 2001-05-20 |
EA000606B1 (en) | 1999-12-29 |
BR9608847A (en) | 1999-06-08 |
EP0830362A4 (en) | 1998-09-02 |
PL323907A1 (en) | 1998-04-27 |
NO975633D0 (en) | 1997-12-04 |
AU6100396A (en) | 1996-12-30 |
KR19990022503A (en) | 1999-03-25 |
MX9709130A (en) | 1998-03-31 |
CA2224225A1 (en) | 1996-12-19 |
EA199800026A1 (en) | 1998-06-25 |
NO975633L (en) | 1998-01-28 |
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