HUP9801086A2 - Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them - Google Patents
Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of themInfo
- Publication number
- HUP9801086A2 HUP9801086A2 HU9801086A HUP9801086A HUP9801086A2 HU P9801086 A2 HUP9801086 A2 HU P9801086A2 HU 9801086 A HU9801086 A HU 9801086A HU P9801086 A HUP9801086 A HU P9801086A HU P9801086 A2 HUP9801086 A2 HU P9801086A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- optionally substituted
- active ingredient
- alkoxy
- phenyl
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- -1 biphenylyl Chemical group 0.000 abstract 2
- 150000001907 coumarones Chemical class 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New benzofuran derivatives (I). Benzofuran derivatives of formula (I) are new. R1, R2 = H or 1-4C alkyl; X = O or S; Y = H or OH; Z' = H, halo, 1-4C alkyl, 1-4C alkoxy, NH2, NO2, CN, CF3, COOR3, NHCOR3 or SO2NR3R4; R3 = H or 1-4C alkyl; R4 = 1-4C alkyl; A = CH, COH, CCN, CCOOR3, COR4; or N-(CH2)n-Ar'; B = methylene group; or A + B = C=C; Ar = H; 1-4C alkyl, phenyl (1-4C alkyl), biphenylyl or naphthyl (optionally substituted by 1-4C alkoxy or 2-4C alkenyl); partially saturated 5- to 6-membered heterocyclic group (optionally substituted by 1-3 1-4C alkyl) condensed with a phenyl group and containing O atom(s); 5-6 membered heterocyclic group containing N and/or O and/or S; or phenyl substituted by R5-R7; R5-R7 = H, halo, CF3, 1-4C alkyl, methylenedioxy, phenoxy (optionally substituted by 1-4C alkoxy or halo); 2-4C alkenyl, 2-4C alkenyloxy, 1-4C alkoxy (optionally substituted by di(1-4C alkyl)amino) or 5 or 6 membered, saturated heterocyclic group containing one or two N or 1 N and 1 O, where the heterocyclic group is optionally substituted by 1-4C alkyl); Ar' = diphenylmethyl, pyrimidinyl, naphthyl (optionally substituted by 1-4C alkoxy or 2-4C alkenyloxy), partially saturated 5-6 membered heterocyclic (optionally substituted by 1-4C alkyl) condensed with a phenyl group and containing O atom(s); or phenyl substituted by R5-R7; n = 0 or 1; or NR3R4 = 5-10 membered heterocyclic group containing N, O and/or S heteroatoms. Independent claims are included for: (1) preparation of (I); (2) intermediates of formula (II) and (V). Hal = halo.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9801086A HUP9801086A3 (en) | 1998-05-14 | 1998-05-14 | Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them |
| SK1721-2000A SK17212000A3 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| EP99923772A EP1077973A2 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| AU40529/99A AU753706B2 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| PCT/HU1999/000038 WO1999058527A2 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| CA002332275A CA2332275A1 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| JP2000548331A JP2002514643A (en) | 1998-05-14 | 1999-05-13 | A benzofuran derivative, a pharmaceutical composition containing the same and a method for producing the active ingredient thereof. |
| PL99345309A PL345309A1 (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| KR1020007012773A KR20010043618A (en) | 1998-05-14 | 1999-05-13 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| HR20000750A HRP20000750A2 (en) | 1998-05-14 | 2000-11-03 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
| US10/736,714 US20040186170A1 (en) | 1998-05-14 | 2003-12-15 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9801086A HUP9801086A3 (en) | 1998-05-14 | 1998-05-14 | Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9801086D0 HU9801086D0 (en) | 1998-07-28 |
| HUP9801086A2 true HUP9801086A2 (en) | 2000-08-28 |
| HUP9801086A3 HUP9801086A3 (en) | 2000-09-28 |
Family
ID=89996543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801086A HUP9801086A3 (en) | 1998-05-14 | 1998-05-14 | Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9801086A3 (en) |
-
1998
- 1998-05-14 HU HU9801086A patent/HUP9801086A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9801086D0 (en) | 1998-07-28 |
| HUP9801086A3 (en) | 2000-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |