HUP9702463A2 - Eljárás és vegyületek anyagok magnetorelaxometriás kimutatásához és ezek alkalmazása - Google Patents

Eljárás és vegyületek anyagok magnetorelaxometriás kimutatásához és ezek alkalmazása

Info

Publication number
HUP9702463A2
HUP9702463A2 HU9702463A HUP9702463A HUP9702463A2 HU P9702463 A2 HUP9702463 A2 HU P9702463A2 HU 9702463 A HU9702463 A HU 9702463A HU P9702463 A HUP9702463 A HU P9702463A HU P9702463 A2 HUP9702463 A2 HU P9702463A2
Authority
HU
Hungary
Prior art keywords
magnetorelaxometric
compounds
analytes
analysis
determination
Prior art date
Application number
HU9702463A
Other languages
English (en)
Inventor
Thomas Bunte
Roman Kötitz
Lutz Trahms
Werner Weitschies
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HUP9702463A2 publication Critical patent/HUP9702463A2/hu
Publication of HUP9702463A3 publication Critical patent/HUP9702463A3/hu
Publication of HU221748B1 publication Critical patent/HU221748B1/hu

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1875—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle coated or functionalised with an antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/916—Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/96—Of magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Endocrinology (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgyai: eljárás anyagők magnetőrelaxőmetriás kvalitatívkiműtatására és/vagy kvantitatív meghatárőzására főlyadék- és szilárdfázisban; a magnetőrelaxőmetriás kiműtatásra szőlgáló vegyületek ésezek alkalmazása az analitikában és az imműnmagnetőgráfiában. A találmány szerinti eljárás és vegyületek különösen a termékenységivizsgálatőkban, a hisztőkőmpatibilitás meghatárőzásában, azallergőlógia, fertőző betegségek, higiénia, genetika, virőlógia,bakteriőlógia, tőxikőlógia, patőlógia, környezetvédelem és őrvősidiagnősztika területén alkalmazhatók. ŕ
HU9702463A 1995-01-27 1996-01-29 Eljárás és vegyületek anyagok magnetorelaxometriás kimutatásához és ezek alkalmazása HU221748B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19503664A DE19503664C2 (de) 1995-01-27 1995-01-27 Magnetorelaxometrische Detektion von Analyten
PCT/EP1996/000339 WO1996023227A1 (de) 1995-01-27 1996-01-29 Verfahren und verbindungen zur magnetorelaxometrischen detektion von analyten und deren verwendung

Publications (3)

Publication Number Publication Date
HUP9702463A2 true HUP9702463A2 (hu) 1998-04-28
HUP9702463A3 HUP9702463A3 (en) 2000-03-28
HU221748B1 HU221748B1 (hu) 2002-12-28

Family

ID=7753173

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702463A HU221748B1 (hu) 1995-01-27 1996-01-29 Eljárás és vegyületek anyagok magnetorelaxometriás kimutatásához és ezek alkalmazása

Country Status (22)

Country Link
US (2) US6027946A (hu)
EP (1) EP0805983B1 (hu)
JP (1) JP3607297B2 (hu)
KR (1) KR100412006B1 (hu)
CN (1) CN1176001A (hu)
AT (1) ATE188778T1 (hu)
AU (1) AU703069B2 (hu)
CA (1) CA2211364A1 (hu)
DE (2) DE19503664C2 (hu)
DK (1) DK0805983T3 (hu)
ES (1) ES2142569T3 (hu)
FI (1) FI973122A0 (hu)
GR (1) GR3033138T3 (hu)
HU (1) HU221748B1 (hu)
IL (1) IL116915A (hu)
NO (1) NO973444D0 (hu)
NZ (1) NZ301665A (hu)
PT (1) PT805983E (hu)
RU (1) RU2176393C2 (hu)
UA (1) UA54384C2 (hu)
WO (1) WO1996023227A1 (hu)
ZA (1) ZA96625B (hu)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19503664C2 (de) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometrische Detektion von Analyten
DE19508772C2 (de) * 1995-03-01 1998-01-29 Schering Ag Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung
DE19615254C2 (de) * 1996-04-18 1999-03-11 Diagnostikforschung Inst Gerät zur höchstempfindlichen magnetischen Detektion von Analyten
WO1998018497A2 (en) * 1996-10-28 1998-05-07 Nycomed Imaging As Contrast agents
US6437563B1 (en) * 1997-11-21 2002-08-20 Quantum Design, Inc. Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
EP1198712A2 (de) * 1999-02-17 2002-04-24 Kilian Hennes Verfahren zum darstellen von biologisch aktivierten induktivitätsändernden partikeln sowie vorrichtung dafür
JP4171139B2 (ja) * 1999-07-21 2008-10-22 住友電気工業株式会社 磁性体標識による免疫検査方法とその装置
JP2003528289A (ja) * 1999-08-06 2003-09-24 インスティテュート・フュア・ディアグノスティクフォルシュンク・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デア・フライエン・ウニヴエアズィテート・ベルリン 磁性粒子の二重屈折の緩和の測定を利用する結合反応を検出するための方法
US6979574B1 (en) * 1999-08-06 2005-12-27 Institut Fuer Diagnostik Forshung Gmbh Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
DE19938372A1 (de) * 1999-08-09 2001-03-08 Diagnostikforschung Inst Verfahren und Vorrichtung zur Trennung magnetischer Teilchen
US6468809B1 (en) * 2000-02-04 2002-10-22 The United States Of America As Represented By The Secretary Of The Navy High efficiency magnetic sensor for magnetic particles
RU2166751C1 (ru) * 2000-03-09 2001-05-10 Никитин Петр Иванович Способ анализа смеси биологических и/или химических компонентов с использованием магнитных частиц и устройство для его осуществления
US20030076087A1 (en) * 2001-08-31 2003-04-24 Imego Ab Method and arrangement relating to substance analysis
US6825655B2 (en) * 2001-08-31 2004-11-30 Imego Ab Method and arrangement for detecting changes of a magnetic response in magnetic particles
WO2003019188A1 (en) 2001-08-31 2003-03-06 Imego Ab Methdo and arrangement for analyzing substances
EP1300684A1 (en) * 2001-10-08 2003-04-09 Barts and The London National Health Service Trust Homogenous ligand binding assay
US8697029B2 (en) * 2002-04-18 2014-04-15 The Regents Of The University Of Michigan Modulated physical and chemical sensors
GB0215185D0 (en) * 2002-07-01 2002-08-07 Genovision As Binding a target substance
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
CN1829916B (zh) * 2003-07-30 2010-09-29 皇家飞利浦电子股份有限公司 用于确定生物活性分子之间结合的磁性粒子的使用
US8118754B1 (en) 2007-11-15 2012-02-21 Flynn Edward R Magnetic needle biopsy
US8060179B1 (en) 2006-11-16 2011-11-15 Scientific Nanomedicine, Inc. Biomagnetic detection and treatment of Alzheimer's Disease
JP3962385B2 (ja) 2004-03-11 2007-08-22 株式会社日立製作所 免疫検査装置及び免疫検査方法
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US7892817B2 (en) * 2004-05-18 2011-02-22 Koninklijke Philips Electronics, N.V. Magnetic rotation to improve signal-over-background in biosensing
CA2575446C (en) * 2004-08-03 2014-03-25 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
US7719265B2 (en) * 2004-11-17 2010-05-18 Honda Motor Co., Ltd. Methods for determining particle size of metal nanocatalyst for growing carbon nanotubes
US9964469B2 (en) 2005-02-28 2018-05-08 Imagion Biosystems, Inc. Magnetic needle separation and optical monitoring
US20080093219A1 (en) * 2005-03-15 2008-04-24 Tufts University Magnetic Protein Nanosensors and Methods of Use
US20070020699A1 (en) * 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
US8735142B2 (en) * 2005-08-16 2014-05-27 Chipotle Business Group, Inc. Systems and methods for immunosorbent assays for single and multiple analytes
US7767404B2 (en) * 2005-08-16 2010-08-03 Chipotle Business Group, Inc. Apparatus and method for single-step immunosorbent assay for single and multiple analytes
DE102006003177A1 (de) * 2006-01-23 2007-08-02 Siemens Ag Vorrichtung und Verfahren zum Nachweis eines Analyten
SE529474C2 (sv) * 2006-04-19 2007-08-21 Imego Ab Detekteringsanordning och förfarande
US8447379B2 (en) 2006-11-16 2013-05-21 Senior Scientific, LLC Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
US9068977B2 (en) * 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
AT503845B1 (de) * 2007-04-11 2008-03-15 Arc Austrian Res Centers Gmbh Optische messverfahren zur molekularen detektion anhand von relaxationsmessungen in optisch anisotropen nanopartikeln
JP5205807B2 (ja) 2007-05-17 2013-06-05 株式会社日立製作所 磁気信号計測装置
ES2665280T3 (es) * 2007-06-29 2018-04-25 Becton, Dickinson And Company Métodos para la extracción y purificación de componentes de muestras biológicas
EP2217928B1 (en) * 2007-12-04 2017-08-09 Pacific Biosciences of California, Inc. Alternate labeling strategies for single molecule sequencing
DE102008013997B4 (de) 2008-03-13 2012-10-31 Bundesrepublik Deutschland, vertr. durch d. Bundesministerium f. Wirtschaft und Technologie, dieses vertreten durch d. Präsidenten d. Physikalisch-Technischen Bundesanstalt Verfahren zum quantitativen Nachweis von Analyten in flüssigem Medium
US8241854B2 (en) * 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
US9167983B2 (en) * 2008-08-15 2015-10-27 The University Of Houston System Imaging method for obtaining spatial distribution of nanoparticles in the body
US9081004B2 (en) * 2009-09-28 2015-07-14 International Business Machines Corporation Circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads
AU2010315007B2 (en) 2009-11-06 2015-05-21 Imagion Biosystems, Inc. Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
US10194825B2 (en) 2009-11-06 2019-02-05 Imagion Biosystems Inc. Methods and apparatuses for the localization and treatment of disease such as cancer
WO2012027747A2 (en) 2010-08-27 2012-03-01 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation sensing systems and methods
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
DE102010043276A1 (de) * 2010-11-03 2012-05-03 Siemens Aktiengesellschaft Magnetische Zelldetektion
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads
WO2012142179A2 (en) 2011-04-11 2012-10-18 The Regents Of The University Of Michigan Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells
US8855957B2 (en) 2011-05-03 2014-10-07 International Business Machines Corporation Method for calibrating read sensors of electromagnetic read-write heads
US9040311B2 (en) 2011-05-03 2015-05-26 International Business Machines Corporation Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
RU2497128C2 (ru) * 2011-12-30 2013-10-27 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" Способ одновременного определения двух аналитов биолюминесцентным молекулярным микроанализом
US20130289383A1 (en) * 2012-04-27 2013-10-31 Edward R. Flynn Magnetic Relaxometry using Brownian Randomization, Neel Relaxation, or Combinations Thereof
US9797817B2 (en) 2012-05-03 2017-10-24 The Regents Of The University Of Michigan Multi-mode separation for target detection
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
US9983110B2 (en) 2013-11-04 2018-05-29 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes
US10338029B2 (en) * 2014-12-10 2019-07-02 General Electric Company Systems and methods for improved physiological monitoring
CN104614513B (zh) * 2015-01-26 2016-05-25 国家纳米科学中心 一种基于磁分离的弛豫时间免疫传感分析方法
DE102015225849A1 (de) * 2015-12-18 2017-06-22 Robert Bosch Gmbh Verfahren zum Nachweis von Partikeln in einer Probe, Nachweisvorrichtung und mikrofluidisches System zum Untersuchen einer Probe
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN106518598A (zh) * 2016-10-09 2017-03-22 大连理工大学 采用n、n‑二甲基乙酰胺溶剂纯化正己烷的装置及方法
WO2019068204A1 (en) * 2017-10-06 2019-04-11 Jin Zhang BIOCATORS BASED ON GIANT MAGNETORESISTANCE
CN111208287B (zh) * 2020-01-16 2022-07-26 长沙理工大学 一种磁共振传感器的构建方法
US11136543B1 (en) 2020-02-11 2021-10-05 Edward R. Flynn Magnetic cell incubation device

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
JP2938918B2 (ja) * 1990-01-25 1999-08-25 ティーディーケイ株式会社 磁気微粒子の粒度測定方法
GB9007408D0 (en) * 1990-04-02 1990-05-30 Nycomed As Compositions
US5164297A (en) * 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
GB9120508D0 (en) * 1991-09-26 1991-11-06 Nycomed As Diagnostic agents
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
DE19503664C2 (de) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometrische Detektion von Analyten

Also Published As

Publication number Publication date
DE19503664A1 (de) 1996-08-01
NO973444L (no) 1997-07-25
EP0805983A1 (de) 1997-11-12
FI973122A (fi) 1997-07-25
NO973444D0 (no) 1997-07-25
WO1996023227A1 (de) 1996-08-01
DE19503664C2 (de) 1998-04-02
KR100412006B1 (ko) 2005-09-30
CA2211364A1 (en) 1996-08-01
UA54384C2 (uk) 2003-03-17
DK0805983T3 (da) 2000-04-25
MX9705543A (es) 1997-10-31
ES2142569T3 (es) 2000-04-16
AU4714996A (en) 1996-08-14
PT805983E (pt) 2000-04-28
IL116915A0 (en) 1996-05-14
HU221748B1 (hu) 2002-12-28
KR19980701711A (ko) 1998-06-25
EP0805983B1 (de) 2000-01-12
GR3033138T3 (en) 2000-08-31
ATE188778T1 (de) 2000-01-15
US6485985B1 (en) 2002-11-26
ZA96625B (en) 1997-07-21
HUP9702463A3 (en) 2000-03-28
IL116915A (en) 2000-12-06
FI973122A0 (fi) 1997-07-25
AU703069B2 (en) 1999-03-11
US6027946A (en) 2000-02-22
JPH10513551A (ja) 1998-12-22
NZ301665A (en) 1999-03-29
CN1176001A (zh) 1998-03-11
RU2176393C2 (ru) 2001-11-27
DE59604171D1 (de) 2000-02-17
JP3607297B2 (ja) 2005-01-05

Similar Documents

Publication Publication Date Title
HUP9702463A2 (hu) Eljárás és vegyületek anyagok magnetorelaxometriás kimutatásához és ezek alkalmazása
ES2112057T3 (es) Metodo de deteccion y/o cuantificacion y/o separacion de celulas apoptosicas dentro de o en una muestra.
TR200000113T2 (tr) Tüberkülozu teşhis etmek için bileşikler ve bunları kullanma yöntemleri.
CA2412121A1 (en) Method for the detection of influenza a/b viruses
MX9801687A (es) Compuestos y metodos para el diagnostico de tuberculosis.
ES2114727T3 (es) Inmunoensayo rapido para deteccion de anticuerpos o antigenos que incorpora extraccion de la muestra y reaccion inmunogena simultaneas.
WO1996007761A3 (en) Method for testing for mutations in dna from a patient sample
DE59108006D1 (de) Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
AU3538195A (en) Assays and devices for the detection of extrahepatic biliary atresia
DE69428958D1 (de) Vorrichtung zum Sammeln und in-vitro-Transport von Proben, insbesondere für Diagnoseverwendungen
BR8906988A (pt) Tetrapiptidio,peptidio,composicao farmaceutica,processo para uso de peptidio e reagente para diagnostico
JP2002504222A (ja) 抗原の ｉｎ ｓｉｔｕ 免疫検出
IT1291913B1 (it) Metodo che prevede l'uso di batteriofagi per la rivelazione della presenza di molecole di interesse in campioni biologici
CA2385830A1 (en) Probe for protein-protein interaction analysis, and method of using it for analysis of protein-protein interaction
IT7922812A0 (it) Dispositivo composito perl'esercizio positivo di segnaletica stradale, e metodo per la sua utilizzazione.
ATE397215T1 (de) Entstörung von immunoassays durch substanzen, die aus den framework-regionen von antikörpern abgeleitet sind
MX9706437A (es) Proceso y compuestos para la deteccion de analitos usando medicion de remanencia y el uso de los mismos.
WO2002015559A3 (en) High-resolution digital image processing in the analysis of pathological materials
PT100731A (pt) Estojo de imunoensaio para a deteccao simultanea de anticorpos de hiv-1,hiv-2,htlv-i e htlv-ii e metodo para a sua preparacao
KR100270632B1 (ko) 표적 항원을 검출하기 위한 동일계 면역 검정 킷
SE8901127D0 (sv) Reagenssats och dess anvaending foer att bilda (spap-anti-spap) -immunkomplex samt diagnostiskt foerfarand vid vilket spap detekteras
DE69731388D1 (de) Nukleinsäure-fragmente, die spezifische für die mitglieder des m. tuberculosis komplexes sind, deren anwendung zur detektion und differentiale diagnose der mitglieder des m. tuberculosis komplexes
CA2213083A1 (en) Detection of antibody production
IE40645B1 (en) Visual method for the detection of syphilis and other treponemal diseases, and an antigen preparation useful therein
RU2000127463A (ru) Способ качественного определения гомеопатического лекарственного препарата или потенцированной формы вещества

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees