HUP9700744A1 - Eljárás 2-[2-[4-[(4-klór-fenil)-fenil-meti]-1-piperazinil]-etoxi]-ecetsav és sói előállítására - Google Patents

Eljárás 2-[2-[4-[(4-klór-fenil)-fenil-meti]-1-piperazinil]-etoxi]-ecetsav és sói előállítására

Info

Publication number
HUP9700744A1
HUP9700744A1 HU9700744A HUP9700744A HUP9700744A1 HU P9700744 A1 HUP9700744 A1 HU P9700744A1 HU 9700744 A HU9700744 A HU 9700744A HU P9700744 A HUP9700744 A HU P9700744A HU P9700744 A1 HUP9700744 A1 HU P9700744A1
Authority
HU
Hungary
Prior art keywords
phenylmethyl
chlorophenyl
piperazinyl
ethoxy
acetic acid
Prior art date
Application number
HU9700744A
Other languages
English (en)
Inventor
Guy Bodson
Guy Duchene
Vincent Zimmermann
Original Assignee
Ucb, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb, S.A. filed Critical Ucb, S.A.
Publication of HU9700744D0 publication Critical patent/HU9700744D0/hu
Publication of HUP9700744A1 publication Critical patent/HUP9700744A1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya új eljárás 2-[2-[4-[(4-klór-fenil)-fenil-metil]-1-piperazinil]-etőxi]-ecetsav, ismert nevén cetirizin vagy sóielőállítására, melynek sőrán 1-[(4-klór-fenil)-fenil-metil]-piperazint2-klór-ető-ecetsavval reagáltatnak inert őldószerben savmegkötő szerjelenlétében. A kapőtt 2-[2-[4-[(4-klór-fenil)-fenil-metil]-2-piperazinil]-etőxi]-ecetsavat előnyösen dihidrőklőridsóvá alakítják. Acetirizin allergiás megbetegedések kezelésére alkalmas. ŕ
HU9700744A 1996-04-10 1997-04-10 Eljárás 2-[2-[4-[(4-klór-fenil)-fenil-meti]-1-piperazinil]-etoxi]-ecetsav és sói előállítására HUP9700744A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE9600311A BE1010095A3 (fr) 1996-04-10 1996-04-10 Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.

Publications (2)

Publication Number Publication Date
HU9700744D0 HU9700744D0 (en) 1997-05-28
HUP9700744A1 true HUP9700744A1 (hu) 2000-06-28

Family

ID=3889664

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700744A HUP9700744A1 (hu) 1996-04-10 1997-04-10 Eljárás 2-[2-[4-[(4-klór-fenil)-fenil-meti]-1-piperazinil]-etoxi]-ecetsav és sói előállítására

Country Status (5)

Country Link
EP (1) EP0801064A1 (hu)
AR (1) AR006555A1 (hu)
BE (1) BE1010095A3 (hu)
HU (1) HUP9700744A1 (hu)
NO (1) NO306860B1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
US6239277B1 (en) * 1999-10-20 2001-05-29 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003237394A1 (en) * 2002-06-05 2003-12-22 Dr. Reddy's Laboratories Limited Crystalline (2-(4-((4-chlorophenyl)-phenyl methyl)-1-piperazinyl) ethoxy) acetic acid dihydrochloride
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505116A (it) * 1966-11-21 1971-03-31 Crc Ricerca Chim Metodo per l'ottenimento di derivati della piperazina
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Also Published As

Publication number Publication date
HU9700744D0 (en) 1997-05-28
NO306860B1 (no) 2000-01-03
AR006555A1 (es) 1999-09-08
BE1010095A3 (fr) 1997-12-02
NO971583L (no) 1997-10-13
NO971583D0 (no) 1997-04-07
EP0801064A1 (fr) 1997-10-15

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