HUP9700609A2 - 1,25-dihydroxy-12,22,23-trisdehydro-cholecalciferol derivatives, pharmaceutical compositions containing the same and intermediates - Google Patents

1,25-dihydroxy-12,22,23-trisdehydro-cholecalciferol derivatives, pharmaceutical compositions containing the same and intermediates

Info

Publication number
HUP9700609A2
HUP9700609A2 HU9700609A HUP9700609A HUP9700609A2 HU P9700609 A2 HUP9700609 A2 HU P9700609A2 HU 9700609 A HU9700609 A HU 9700609A HU P9700609 A HUP9700609 A HU P9700609A HU P9700609 A2 HUP9700609 A2 HU P9700609A2
Authority
HU
Hungary
Prior art keywords
trisdehydro
dihydroxy
intermediates
same
pharmaceutical compositions
Prior art date
Application number
HU9700609A
Other languages
Hungarian (hu)
Inventor
Bernard Michael Hennessy
Jerome Anthony Iacobelli
Milan Radoje Uskokovic
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of HU9700609D0 publication Critical patent/HU9700609D0/en
Publication of HUP9700609A2 publication Critical patent/HUP9700609A2/en
Publication of HUP9700609A3 publication Critical patent/HUP9700609A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A találmány (I) általánős képletű vegyületekre vőnatkőzik[mely képletben R jelentése hidrőxilcsőpőrt és R1 jelentése H2 vagyCH2; vagy R jelentése hidrőgén- vagy flűőratőm és R1 jelentése CH2).Az (I) általánős képletű vegyületek hiperbűrjánzásős bőrbetegségek(pl. psőriasis), neőpláziás betegségek (pl. leűkémia) ésfaggyúmirigybetegségek (pl. akne és sebhőrreás dermatitis) kezelésérealkalmazhatók.ŕThe invention relates to compounds of the general formula (I) [in which formula R is hydroxyl group powder and R1 is H2 or CH2; or R represents a hydrogen or fluorine atom and R1 represents CH2). The compounds of general formula (I) can be used for the treatment of hyperproliferative skin diseases (e.g. psoriasis), gynecomastia (e.g. leukaemia) and sebaceous gland diseases (e.g. acne and psoriatic dermatitis).

HU9700609A 1996-03-21 1997-03-19 1,25-dihydroxy-12,22,23-trisdehydro-cholecalciferol derivatives, pharmaceutical compositions containing the same and intermediates HUP9700609A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1380996P 1996-03-21 1996-03-21

Publications (3)

Publication Number Publication Date
HU9700609D0 HU9700609D0 (en) 1997-05-28
HUP9700609A2 true HUP9700609A2 (en) 1998-07-28
HUP9700609A3 HUP9700609A3 (en) 1999-03-01

Family

ID=21761865

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700609A HUP9700609A3 (en) 1996-03-21 1997-03-19 1,25-dihydroxy-12,22,23-trisdehydro-cholecalciferol derivatives, pharmaceutical compositions containing the same and intermediates

Country Status (30)

Country Link
EP (1) EP0796843B1 (en)
JP (1) JP2801587B2 (en)
KR (1) KR100240541B1 (en)
CN (1) CN1110477C (en)
AR (1) AR006315A1 (en)
AT (1) ATE240941T1 (en)
AU (1) AU708679B2 (en)
BR (1) BR9701404A (en)
CA (1) CA2199893C (en)
CO (1) CO4820396A1 (en)
CZ (1) CZ85897A3 (en)
DE (1) DE69722064T2 (en)
DK (1) DK0796843T3 (en)
ES (1) ES2198512T3 (en)
HR (1) HRP970162A2 (en)
HU (1) HUP9700609A3 (en)
ID (1) ID16285A (en)
IL (1) IL120469A0 (en)
MA (1) MA26423A1 (en)
MX (1) MX9702139A (en)
NO (1) NO971217L (en)
NZ (1) NZ314424A (en)
PE (1) PE42998A1 (en)
PL (1) PL319070A1 (en)
PT (1) PT796843E (en)
SG (1) SG70589A1 (en)
TR (1) TR199700219A3 (en)
TW (1) TW444001B (en)
YU (1) YU10397A (en)
ZA (1) ZA972302B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
KR101285720B1 (en) * 2012-03-02 2013-07-19 주식회사 유니크메디케어 Composition for improving acne
KR102493627B1 (en) 2015-11-26 2023-01-31 코웨이 주식회사 Pharmaceutical Composition Comprising Hordenine as Active Ingredient for Preventing or Treating Skin Cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
DK0398217T3 (en) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferol derivatives

Also Published As

Publication number Publication date
CA2199893C (en) 2008-02-05
YU10397A (en) 1999-07-28
CZ85897A3 (en) 1998-04-15
EP0796843A2 (en) 1997-09-24
CN1172793A (en) 1998-02-11
AR006315A1 (en) 1999-08-25
DE69722064D1 (en) 2003-06-26
KR970065495A (en) 1997-10-13
CA2199893A1 (en) 1997-09-21
SG70589A1 (en) 2000-02-22
TR199700219A2 (en) 1997-10-21
TW444001B (en) 2001-07-01
PL319070A1 (en) 1997-09-29
TR199700219A3 (en) 1997-10-21
IL120469A0 (en) 1997-07-13
ZA972302B (en) 1997-09-22
BR9701404A (en) 1998-11-03
CN1110477C (en) 2003-06-04
EP0796843B1 (en) 2003-05-21
HU9700609D0 (en) 1997-05-28
JPH107651A (en) 1998-01-13
AU708679B2 (en) 1999-08-12
MA26423A1 (en) 2004-12-20
ATE240941T1 (en) 2003-06-15
KR100240541B1 (en) 2000-01-15
MX9702139A (en) 1998-04-30
JP2801587B2 (en) 1998-09-21
ID16285A (en) 1997-09-18
AU1513597A (en) 1997-09-25
DE69722064T2 (en) 2004-04-08
DK0796843T3 (en) 2003-09-15
CO4820396A1 (en) 1999-07-28
ES2198512T3 (en) 2004-02-01
PE42998A1 (en) 1998-08-11
HRP970162A2 (en) 1998-04-30
PT796843E (en) 2003-09-30
EP0796843A3 (en) 1999-04-14
NO971217D0 (en) 1997-03-17
NO971217L (en) 1997-09-22
HUP9700609A3 (en) 1999-03-01
NZ314424A (en) 1998-07-28

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