HUP1800129A1 - A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek - Google Patents

A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek

Info

Publication number
HUP1800129A1
HUP1800129A1 HUP1800129A HUP1800129A1 HU P1800129 A1 HUP1800129 A1 HU P1800129A1 HU P1800129 A HUP1800129 A HU P1800129A HU P1800129 A1 HUP1800129 A1 HU P1800129A1
Authority
HU
Hungary
Prior art keywords
isoforms
compounds
selectively inhibiting
inhibiting myosin
myosin
Prior art date
Application number
Other languages
English (en)
Inventor
Andras Malnasi-Csizmadia
Mate Gyimesi
Andras Szabo
Peter Hari
Kumar Suthar Sharad
Mihaly Kovacs
Adam Istvan Horvath
Mate Penzes
Istvan Loerincz
Original Assignee
Printnet Kereskedelmi Es Szolgaltato Kft
Soneas Kutato Kft
Eoetvoes Lorand Tudomanyegyetem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Printnet Kereskedelmi Es Szolgaltato Kft, Soneas Kutato Kft, Eoetvoes Lorand Tudomanyegyetem filed Critical Printnet Kereskedelmi Es Szolgaltato Kft
Priority to HU1800129A priority Critical patent/HU231285B1/hu
Priority to PCT/HU2019/050017 priority patent/WO2019202346A2/en
Priority to ES19779087T priority patent/ES2963548T3/es
Priority to KR1020207033132A priority patent/KR20210010465A/ko
Priority to EP19779087.6A priority patent/EP3781263B1/en
Priority to US17/048,206 priority patent/US11746112B2/en
Priority to AU2019256801A priority patent/AU2019256801A1/en
Priority to MX2020011020A priority patent/MX2020011020A/es
Priority to MA052298A priority patent/MA52298A/fr
Priority to CA3097479A priority patent/CA3097479A1/en
Priority to HUE19779087A priority patent/HUE063424T2/hu
Priority to IL278105A priority patent/IL278105B2/en
Priority to FIEP19779087.6T priority patent/FI3781263T3/fi
Priority to PL19779087.6T priority patent/PL3781263T3/pl
Priority to BR112020021347-0A priority patent/BR112020021347A2/pt
Priority to PT197790876T priority patent/PT3781263T/pt
Priority to JP2021506072A priority patent/JP7463344B2/ja
Priority to EP23184543.9A priority patent/EP4276102A3/en
Priority to CN201980040782.2A priority patent/CN112334191A/zh
Priority to SG11202010177UA priority patent/SG11202010177UA/en
Priority to DK19779087.6T priority patent/DK3781263T3/da
Priority to SI201930626T priority patent/SI3781263T1/sl
Priority to CN202311771677.0A priority patent/CN117924285A/zh
Publication of HUP1800129A1 publication Critical patent/HUP1800129A1/hu
Priority to PH12020551734A priority patent/PH12020551734A1/en
Publication of HU231285B1 publication Critical patent/HU231285B1/hu
Priority to US18/345,772 priority patent/US11845758B2/en
Priority to JP2024050808A priority patent/JP2024075759A/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU1800129A 2018-04-18 2018-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek HU231285B1 (hu)

Priority Applications (26)

Application Number Priority Date Filing Date Title
HU1800129A HU231285B1 (hu) 2018-04-18 2018-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
KR1020207033132A KR20210010465A (ko) 2018-04-18 2019-04-18 미오신 2 이소형을 선택적으로 억제하는 약제학적으로 효과적인 화합물
DK19779087.6T DK3781263T3 (da) 2018-04-18 2019-04-18 Farmaceutisk effektive forbindelser, der selektivt hæmmer myosin-2-isoformerne
PL19779087.6T PL3781263T3 (pl) 2018-04-18 2019-04-18 Farmaceutycznie skuteczne związki selektywnie hamujące izoformy miozyny 2
EP19779087.6A EP3781263B1 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
US17/048,206 US11746112B2 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
AU2019256801A AU2019256801A1 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
MX2020011020A MX2020011020A (es) 2018-04-18 2019-04-18 Compuestos farmaceuticamente efectivos que inhiben selectivamente las isoformas de miosina 2.
MA052298A MA52298A (fr) 2018-04-18 2019-04-18 Composés pharmaceutiquement efficaces inhibant sélectivement les isoformes de myosine 2
CA3097479A CA3097479A1 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
HUE19779087A HUE063424T2 (hu) 2018-04-18 2019-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
IL278105A IL278105B2 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds that selectively inhibit myosin 2 isoforms
FIEP19779087.6T FI3781263T3 (fi) 2018-04-18 2019-04-18 Myosiini 2 -isoformeja selektiivisesti estäviä farmaseuttisesti tehokkaita yhdisteitä
PCT/HU2019/050017 WO2019202346A2 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
BR112020021347-0A BR112020021347A2 (pt) 2018-04-18 2019-04-18 Compostos farmaceuticamente eficazes que inibe seletivamente as isoformas de miosina 2
CN202311771677.0A CN117924285A (zh) 2018-04-18 2019-04-18 选择性抑制肌球蛋白2同工型的药学有效化合物
JP2021506072A JP7463344B2 (ja) 2018-04-18 2019-04-18 ミオシン2アイソフォームを選択的に阻害する医薬的に有効な化合物
EP23184543.9A EP4276102A3 (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
CN201980040782.2A CN112334191A (zh) 2018-04-18 2019-04-18 选择性抑制肌球蛋白2同工型的药学有效化合物
SG11202010177UA SG11202010177UA (en) 2018-04-18 2019-04-18 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
ES19779087T ES2963548T3 (es) 2018-04-18 2019-04-18 Compuestos farmacéuticamente eficaces que inhiben selectivamente las isoformas de miosina 2
SI201930626T SI3781263T1 (sl) 2018-04-18 2019-04-18 Farmacevtsko učinkovite spojine, ki selektivno zavirajo izooblike miozina 2
PT197790876T PT3781263T (pt) 2018-04-18 2019-04-18 Compostos farmaceuticamente aceitáveis que inibem seletivamente as isoformas de miosina 2
PH12020551734A PH12020551734A1 (en) 2018-04-18 2020-10-17 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
US18/345,772 US11845758B2 (en) 2018-04-18 2023-06-30 Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
JP2024050808A JP2024075759A (ja) 2018-04-18 2024-03-27 ミオシン2アイソフォームを選択的に阻害する医薬的に有効な化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1800129A HU231285B1 (hu) 2018-04-18 2018-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek

Publications (2)

Publication Number Publication Date
HUP1800129A1 true HUP1800129A1 (hu) 2019-10-28
HU231285B1 HU231285B1 (hu) 2022-08-28

Family

ID=89992670

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1800129A HU231285B1 (hu) 2018-04-18 2018-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
HUE19779087A HUE063424T2 (hu) 2018-04-18 2019-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE19779087A HUE063424T2 (hu) 2018-04-18 2019-04-18 A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek

Country Status (21)

Country Link
US (2) US11746112B2 (hu)
EP (2) EP3781263B1 (hu)
JP (2) JP7463344B2 (hu)
KR (1) KR20210010465A (hu)
CN (2) CN117924285A (hu)
AU (1) AU2019256801A1 (hu)
BR (1) BR112020021347A2 (hu)
CA (1) CA3097479A1 (hu)
DK (1) DK3781263T3 (hu)
ES (1) ES2963548T3 (hu)
FI (1) FI3781263T3 (hu)
HU (2) HU231285B1 (hu)
IL (1) IL278105B2 (hu)
MA (1) MA52298A (hu)
MX (1) MX2020011020A (hu)
PH (1) PH12020551734A1 (hu)
PL (1) PL3781263T3 (hu)
PT (1) PT3781263T (hu)
SG (1) SG11202010177UA (hu)
SI (1) SI3781263T1 (hu)
WO (1) WO2019202346A2 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231285B1 (hu) 2018-04-18 2022-08-28 Printnet Kereskedelmi És Szolgáltató Kft. A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
KR102559394B1 (ko) 2018-06-14 2023-07-27 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 물질 사용 재발에 사용되는 비근육 미오신 ii 억제제

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* Cited by examiner, † Cited by third party
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NZ216519A (en) 1985-06-13 1989-02-24 Schering Corp Polycyclic compounds and pharmaceutical compositions
JP2011510933A (ja) * 2008-01-31 2011-04-07 モナシュ ユニバーシティ 血栓塞栓性障害を治療する方法
WO2010120785A2 (en) 2009-04-13 2010-10-21 The Regents Of The University Of California Methods and compositions for stem cell cultures
AU2011250651B2 (en) 2010-05-05 2015-10-08 Genea Ip Holdings Pty Limited Media and methods for cell culture
EP2492687A1 (en) 2011-02-23 2012-08-29 Institut Gustave Roussy -Igr- MYH10 as a new diagnostic marker of pathologies resulting from RUNX1 inactivation
US9492441B2 (en) 2011-05-18 2016-11-15 Michael E. DiSanto Drug treatment of overactive bladder
US9994564B2 (en) * 2011-05-18 2018-06-12 Michael E. DiSanto Myosin II ATPase inhibitor compounds
EP2524915A1 (en) 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
EP2777703B1 (en) * 2013-03-15 2016-09-14 Lonza Cologne GmbH Compositions and methods for enhancing the therapeutic potential of stem cells
CA2937460A1 (en) * 2014-02-18 2015-08-27 Etablissement Francais Du Sang High-resolution hla typing
AU2016243750B2 (en) 2015-04-03 2022-02-03 Propagenix Inc. Ex vivo proliferation of epithelial cells
WO2016180918A1 (en) 2015-05-12 2016-11-17 Platod Combination of pharmacological and microfluidic features for improved platelets production
US10858357B2 (en) 2016-01-29 2020-12-08 Paris Sciences Et Lettres-Quartier Latin Water-soluble myosin 2 inhibitors for the treatment of neurological, neuropathic or psychiatric diseases
WO2019164852A1 (en) 2018-02-20 2019-08-29 Edgewise Therapeutics, Inc. Methods and compositions for treating movement disorders
HU231285B1 (hu) 2018-04-18 2022-08-28 Printnet Kereskedelmi És Szolgáltató Kft. A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
KR102559394B1 (ko) 2018-06-14 2023-07-27 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 물질 사용 재발에 사용되는 비근육 미오신 ii 억제제
WO2020097266A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof

Also Published As

Publication number Publication date
EP3781263B1 (en) 2023-07-12
EP4276102A2 (en) 2023-11-15
WO2019202346A3 (en) 2019-12-19
MA52298A (fr) 2021-02-24
MX2020011020A (es) 2021-01-08
DK3781263T3 (da) 2023-10-02
EP3781263A2 (en) 2021-02-24
PL3781263T3 (pl) 2024-01-22
BR112020021347A2 (pt) 2021-01-19
PT3781263T (pt) 2023-10-13
CN112334191A (zh) 2021-02-05
IL278105B2 (en) 2024-05-01
CN117924285A (zh) 2024-04-26
IL278105B1 (en) 2024-01-01
HU231285B1 (hu) 2022-08-28
US11845758B2 (en) 2023-12-19
US11746112B2 (en) 2023-09-05
KR20210010465A (ko) 2021-01-27
JP7463344B2 (ja) 2024-04-08
HUE063424T2 (hu) 2024-01-28
IL278105A (hu) 2020-12-31
AU2019256801A1 (en) 2020-12-17
JP2024075759A (ja) 2024-06-04
FI3781263T3 (fi) 2023-09-15
SG11202010177UA (en) 2020-11-27
SI3781263T1 (sl) 2024-01-31
EP4276102A3 (en) 2023-12-06
PH12020551734A1 (en) 2021-06-07
US20230339959A1 (en) 2023-10-26
WO2019202346A2 (en) 2019-10-24
ES2963548T3 (es) 2024-03-27
JP2021522322A (ja) 2021-08-30
CA3097479A1 (en) 2019-10-24
US20210087201A1 (en) 2021-03-25

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