HUP1300733A2 - A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan - Google Patents

A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Info

Publication number
HUP1300733A2
HUP1300733A2 HU1300733A HUP1300733A HUP1300733A2 HU P1300733 A2 HUP1300733 A2 HU P1300733A2 HU 1300733 A HU1300733 A HU 1300733A HU P1300733 A HUP1300733 A HU P1300733A HU P1300733 A2 HUP1300733 A2 HU P1300733A2
Authority
HU
Hungary
Prior art keywords
azilsartan
oxadiazol
carboxylates
benzo
biphenyl
Prior art date
Application number
HU1300733A
Other languages
Hungarian (hu)
Inventor
Stanislav Radl
Jan Stach
Original Assignee
Zentiva As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As filed Critical Zentiva As
Publication of HUP1300733A2 publication Critical patent/HUP1300733A2/en
Publication of HU230577B1 publication Critical patent/HU230577B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU1300733A 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan HU230577B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2011-208 2011-04-11
CZ20110208A CZ303505B6 (en) 2011-04-11 2011-04-11 Process for preparing 2-ethoxy-1-((2?-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylates through their conversion to azilsartan
PCT/CZ2012/000030 WO2012139535A1 (en) 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Publications (2)

Publication Number Publication Date
HUP1300733A2 true HUP1300733A2 (en) 2014-03-28
HU230577B1 HU230577B1 (en) 2017-01-30

Family

ID=46000594

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1300733A HU230577B1 (en) 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Country Status (3)

Country Link
CZ (1) CZ303505B6 (en)
HU (1) HU230577B1 (en)
WO (1) WO2012139535A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014530805A (en) * 2011-09-30 2014-11-20 スンシネ ルアケ プハルマ カンパニー リミテッド Crystal form of azilsartan and its production and use
CN103044412B (en) * 2012-12-26 2016-04-06 华润赛科药业有限责任公司 Polymorphic of a kind of Azilsartan and preparation method thereof
CN104072491A (en) * 2013-03-29 2014-10-01 天津药物研究院 Azilsartan derivative compound and preparation method and application thereof
CN103254188B (en) * 2013-05-22 2015-09-02 黄冈鲁班药业有限公司 A kind of preparation method of Azilsartan derivative
CN103588764B (en) * 2013-11-11 2015-12-30 浙江永宁药业股份有限公司 The synthetic method of Azilsartan or its salt and intermediate thereof
CN103601723B (en) * 2013-11-19 2016-04-27 合肥远志医药科技开发有限公司 A kind of industrialized preparing process of Azilsartan
CZ2014702A3 (en) * 2014-10-15 2016-04-27 Zentiva, K.S. Process for preparing extremely pure azilsartan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03258779A (en) * 1990-03-06 1991-11-19 Mitsui Toatsu Chem Inc Imidazole derivative and anticonvulsant containing the same imidazole derivative as active ingredient
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
GB9320744D0 (en) * 1992-11-04 1993-12-01 Zeneca Ltd Oxa and thiadiazole derivatives
DE4408497A1 (en) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K New bi:phenyl-methyl-benzimidazole derivs.

Also Published As

Publication number Publication date
CZ2011208A3 (en) 2012-10-24
WO2012139535A1 (en) 2012-10-18
CZ303505B6 (en) 2012-10-24
HU230577B1 (en) 2017-01-30

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