WO2012056294A8 - An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-l-valine - Google Patents

An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-l-valine Download PDF

Info

Publication number
WO2012056294A8
WO2012056294A8 PCT/IB2011/002538 IB2011002538W WO2012056294A8 WO 2012056294 A8 WO2012056294 A8 WO 2012056294A8 IB 2011002538 W IB2011002538 W IB 2011002538W WO 2012056294 A8 WO2012056294 A8 WO 2012056294A8
Authority
WO
WIPO (PCT)
Prior art keywords
pentanoyl
tetrazol
valine
biphenyl
methyl
Prior art date
Application number
PCT/IB2011/002538
Other languages
French (fr)
Other versions
WO2012056294A1 (en
Inventor
Jag Mohan Khanna
Anil Ganpatrao Holkar
Radheshyam Allugulasetty
Chandrashekhar Yelakanti
Original Assignee
Jubilant Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Life Sciences Ltd. filed Critical Jubilant Life Sciences Ltd.
Publication of WO2012056294A1 publication Critical patent/WO2012056294A1/en
Publication of WO2012056294A8 publication Critical patent/WO2012056294A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Abstract

Disclosed herein is an improved process for the preparation of pure N-Pentanoyl-N-[[2'- (1h-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]-L-Valine employing highly active carbon.
PCT/IB2011/002538 2010-10-29 2011-10-25 An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine WO2012056294A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2591/DEL/2010 2010-10-29
IN2591DE2010 2010-10-29

Publications (2)

Publication Number Publication Date
WO2012056294A1 WO2012056294A1 (en) 2012-05-03
WO2012056294A8 true WO2012056294A8 (en) 2012-09-20

Family

ID=45315848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002538 WO2012056294A1 (en) 2010-10-29 2011-10-25 An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine

Country Status (1)

Country Link
WO (1) WO2012056294A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102875485A (en) * 2012-09-29 2013-01-16 华润赛科药业有限责任公司 Method for controlling impurity VLSI-M in valsartan
CN103554049B (en) * 2013-11-08 2016-03-23 浙江新赛科药业有限公司 A kind of method preparing valsartan
CN104072386A (en) * 2014-06-28 2014-10-01 浙江华海药业股份有限公司 Improvement method of valsartan intermediate
CN108047152A (en) * 2017-12-12 2018-05-18 湖南千金协力药业有限公司 A kind of process for purification of Valsartan
CN110078640B (en) * 2019-03-29 2022-04-05 浙江美诺华药物化学有限公司 Synthesis method of valsartan intermediate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97219A (en) 1990-02-19 1995-12-08 Ciba Geigy Ag Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them
US5260325A (en) 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides
WO1997030036A1 (en) 1996-02-15 1997-08-21 Novartis Ag Aryl derivatives
IT1292437B1 (en) 1997-06-30 1999-02-08 Zambon Spa ORTHO-METALLATION PROCESS USEFUL FOR THE SYNTHESIS OF 1 - TETRAZOL- 5-IL) 2-SUBSTITUTED BENZENES
IT1301759B1 (en) 1998-06-19 2000-07-07 Nicox Sa NITRATED SALTS OF ANTI-HYPERTENSIVE DRUGS
WO2001082858A2 (en) 2000-05-04 2001-11-08 Ipf Pharmaceuticals Gmbh Novel compounds for the treatment of inflammatory and cardiovascular diseases
PE20020613A1 (en) 2000-07-19 2002-08-07 Novartis Ag SALTS OF (S) -N- (1-CARBOXY-2-METHYL-PROP-1-IL) -N-PENTANOYL-N- [2 '- (1H-TETRAZOLE-5-IL) -BIPHENYL-4-ILMETHYL] -AMINE AS ANTAGONIST OF THE AT1 RECEPTOR
US7659406B2 (en) * 2005-01-03 2010-02-09 Dr. Reddy's Laboratories Limited Process for preparing valsartan
WO2008007391A2 (en) 2006-07-10 2008-01-17 Manne Satyanarayana Reddy An improved process for the preparation of valsartan

Also Published As

Publication number Publication date
WO2012056294A1 (en) 2012-05-03

Similar Documents

Publication Publication Date Title
WO2011012816A3 (en) Pharmaceutical formulation
WO2010128050A3 (en) Dihydroorotate - dehydrogenasee inhibitors as virostatic compounds
WO2012025944A3 (en) Sitagliptin, salts and polymorphs thereof
MX2011012739A (en) Fluorinated aminotriazole derivatives.
WO2011039735A3 (en) Compounds with ddx3 inhibitory activity and uses thereof
WO2012056294A8 (en) An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-l-valine
MX347734B (en) S100a4 antibodies and therapeutic uses thereof.
TW200942524A (en) Novel aminomethyl benzene derivatives
WO2012078757A3 (en) Combination for breast cancer therapy with hsp90 inhibitory compounds
WO2011006935A3 (en) Tetrazole derivatives
MX2012007590A (en) Composition for improving brain function and method for improving brain function.
WO2011079193A3 (en) Preparation of bendamustine and its salts
WO2012135615A3 (en) Enopeptins, uses thereof, and methods of synthesis thereto
WO2009060952A1 (en) Novel preparation
WO2012003932A3 (en) Use of parvovirus for eliminating cancer stem cells (cscs)
WO2012007846A3 (en) A combination pharmaceutical composition and methods of treating diseases or conditions associated with the cardiovascular system
WO2009144551A3 (en) Use of dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for regulating the potassium level in the blood
WO2010121675A3 (en) Thiazolyl-benzimidazoles
WO2012075015A3 (en) Oral metronidazole pharmaceutical compositions
WO2010012940A3 (en) Microparticulate oral drug form useful for the modified release of nanoparticles
WO2010034976A3 (en) Co-crystals
WO2009124733A8 (en) Substituted sulfonamide derivatives
WO2009011901A3 (en) Methods for promoting wakefulness
WO2011042890A3 (en) Use of phenolic compounds for protein deglycolysation
WO2012015687A3 (en) Drug-ligand conjugates, synthesis thereof, and intermediates thereto

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11794227

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct app. not ent. europ. phase

Ref document number: 11794227

Country of ref document: EP

Kind code of ref document: A1