HUP1300730A2 - A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan - Google Patents

A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Info

Publication number
HUP1300730A2
HUP1300730A2 HU1300730A HUP1300730A HUP1300730A2 HU P1300730 A2 HUP1300730 A2 HU P1300730A2 HU 1300730 A HU1300730 A HU 1300730A HU P1300730 A HUP1300730 A HU P1300730A HU P1300730 A2 HUP1300730 A2 HU P1300730A2
Authority
HU
Hungary
Prior art keywords
azilsartan
oxadiazol
carboxylates
benzo
biphenyl
Prior art date
Application number
HU1300730A
Other languages
Hungarian (hu)
Inventor
Stanislav Radl
Original Assignee
Zentiva As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As filed Critical Zentiva As
Publication of HUP1300730A2 publication Critical patent/HUP1300730A2/en
Publication of HU230540B1 publication Critical patent/HU230540B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU1300730A 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan HU230540B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ2011-209A CZ304252B6 (en) 2011-04-11 2011-04-11 Process for preparing 2-ethoxy-1-((2´-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylates and their conversion to azilsartan
CZPV2011-209 2011-04-11
PCT/CZ2012/000031 WO2012139536A1 (en) 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Publications (2)

Publication Number Publication Date
HUP1300730A2 true HUP1300730A2 (en) 2014-03-28
HU230540B1 HU230540B1 (en) 2016-11-28

Family

ID=46000595

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1300730A HU230540B1 (en) 2011-04-11 2012-04-04 A method of preparing 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl- 4-yl)methyl)-1h-benzo[d]imidazole-7-carboxylates and conversion thereof to azilsartan

Country Status (3)

Country Link
CZ (1) CZ304252B6 (en)
HU (1) HU230540B1 (en)
WO (1) WO2012139536A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930419B (en) * 2011-09-30 2016-06-01 广东东阳光药业有限公司 The brilliant type of Azilsartan and its preparation method
CN103664921B (en) * 2013-11-27 2016-08-24 湖南千金湘江药业股份有限公司 A kind of Azilsartan crystal formation A and preparation method thereof
CN103709155A (en) * 2013-12-30 2014-04-09 江西制药有限责任公司 Preparation method of azilsartan
CN104119279B (en) * 2014-05-30 2018-01-02 上海天慈生物谷生物工程有限公司 The method for preparing the carboxylic acid of 2 ethyoxyl 1 { [base of 2 ' (base of 5 carbonyl, 4,5 dihydro, 1,2,4 oxadiazole 3) xenyl 4] methyl } 1H benzimidazoles 7
CN104230910B (en) * 2014-09-16 2016-08-31 常州大学 The crystal formation of a kind of Azilsartan intermediate and the preparation method of crystal thereof
CN104262334A (en) * 2014-09-16 2015-01-07 常州大学 Azilsartan crystal and preparation method thereof
CZ2014702A3 (en) * 2014-10-15 2016-04-27 Zentiva, K.S. Process for preparing extremely pure azilsartan
JP6948693B2 (en) * 2017-05-23 2021-10-13 金剛化学株式会社 Method for Producing Azilsartan Synthetic Intermediate
CN108640911B (en) * 2018-04-03 2020-03-27 科兴生物制药股份有限公司 Preparation method of azilsartan
WO2020101450A1 (en) * 2018-11-16 2020-05-22 엠에프씨 주식회사 Derivative compounds of azilsartan, intermediates thereof, preparation method therefor, and pharmaceutical composition comprising same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03258779A (en) * 1990-03-06 1991-11-19 Mitsui Toatsu Chem Inc Imidazole derivative and anticonvulsant containing the same imidazole derivative as active ingredient
IL102183A (en) 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
GEP20115138B (en) * 2005-03-30 2011-01-10 Takeda Pharmaceuticals Co Benzimidazole derivative and use as angiotensin ii antagonist
US8501750B2 (en) * 2007-05-21 2013-08-06 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
MA33071B1 (en) * 2009-01-30 2012-02-01 Takeda Pharmaceutical Composite of intensive nucleus and its use

Also Published As

Publication number Publication date
HU230540B1 (en) 2016-11-28
CZ304252B6 (en) 2014-01-29
WO2012139536A1 (en) 2012-10-18
CZ2011209A3 (en) 2012-10-24

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