HUP1300221A2 - Isitope containing morphine derivatives - Google Patents

Isitope containing morphine derivatives

Info

Publication number
HUP1300221A2
HUP1300221A2 HU1300221A HUP1300221A HUP1300221A2 HU P1300221 A2 HUP1300221 A2 HU P1300221A2 HU 1300221 A HU1300221 A HU 1300221A HU P1300221 A HUP1300221 A HU P1300221A HU P1300221 A2 HUP1300221 A2 HU P1300221A2
Authority
HU
Hungary
Prior art keywords
isitope
morphine derivatives
containing morphine
derivatives
morphine
Prior art date
Application number
HU1300221A
Other languages
English (en)
Inventor
Fueloep Ferenc Dr
Mandity Istvan Dr
Original Assignee
Univ Szegedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Szegedi filed Critical Univ Szegedi
Priority to HU1300221A priority Critical patent/HU231191B1/hu
Priority to EP17167947.5A priority patent/EP3312183B1/en
Priority to EP14727037.5A priority patent/EP2986612B1/en
Priority to PCT/HU2014/000030 priority patent/WO2014170704A1/en
Priority to US14/781,116 priority patent/US9447108B2/en
Publication of HUP1300221A2 publication Critical patent/HUP1300221A2/hu
Publication of HU231191B1 publication Critical patent/HU231191B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU1300221A 2013-04-15 2013-04-15 Izotóp tartalmú morfin molekulák HU231191B1 (hu)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HU1300221A HU231191B1 (hu) 2013-04-15 2013-04-15 Izotóp tartalmú morfin molekulák
EP17167947.5A EP3312183B1 (en) 2013-04-15 2014-04-14 Deuterated morphine derivatives for use in analgesia
EP14727037.5A EP2986612B1 (en) 2013-04-15 2014-04-14 Deuterated morphine derivatives
PCT/HU2014/000030 WO2014170704A1 (en) 2013-04-15 2014-04-14 Deuterated morphine derivatives
US14/781,116 US9447108B2 (en) 2013-04-15 2014-04-14 Deuterated morphine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1300221A HU231191B1 (hu) 2013-04-15 2013-04-15 Izotóp tartalmú morfin molekulák

Publications (2)

Publication Number Publication Date
HUP1300221A2 true HUP1300221A2 (en) 2014-10-28
HU231191B1 HU231191B1 (hu) 2021-08-30

Family

ID=89991096

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1300221A HU231191B1 (hu) 2013-04-15 2013-04-15 Izotóp tartalmú morfin molekulák

Country Status (4)

Country Link
US (1) US9447108B2 (hu)
EP (2) EP3312183B1 (hu)
HU (1) HU231191B1 (hu)
WO (1) WO2014170704A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
WO2017165738A1 (en) 2016-03-25 2017-09-28 The Trustees Of Columbia University In The City Of New York Mitragynine alkaloids as opioid receptor modulators
WO2018089797A1 (en) 2016-11-14 2018-05-17 Mingwu Wang Formulations for the treatment of ocular surface diseases and related methods
US20220135564A1 (en) * 2019-02-01 2022-05-05 The Trustees Of Columbia University In The City Of New York Deuterated mitragynine analogs as safer opioid modulators in the mitragynine class
US20230102206A1 (en) * 2020-03-05 2023-03-30 The Trustees Of Columbia University In The City Of New York Ibogaine analogs as therapeutics for neurological and psychiatric disorders
WO2022225884A1 (en) * 2021-04-22 2022-10-27 Lennham Pharmaceuticals, Inc. Deuterated derivatives of psychedelic compounds and uses thereof
IL309073A (en) * 2021-06-03 2024-02-01 Arcadia Medicine Inc Enantiomeric entactogen compounds and methods of their use.
WO2023115006A1 (en) * 2021-12-16 2023-06-22 Terran Biosciences, Inc. Isotopically enriched analogs of 2-bromo-lsd, lsd, ald-52, and 1p-lsd

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3153042A (en) 1964-10-13 Morphinone and codeinone derivatives
US1980972A (en) 1934-07-19 1934-11-13 Small Lyndon Frederick Morphine derivative and processes for its preparation
US2178010A (en) 1937-02-03 1939-10-31 Small Lyndon Frederick Nuclear substituted derivatives of the morphine series and methods for their preparation
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3814768A (en) 1971-11-26 1974-06-04 Lewenstein E 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
SE9401727D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds I
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
DE19939044A1 (de) 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
HU229938B1 (en) 2001-05-03 2015-01-28 Hoffmann La Roche Pharmaceutical dosage form of amorphous nelfinavir mesylate
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US6740641B2 (en) 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
WO2006039237A1 (en) 2004-09-29 2006-04-13 Cordis Corporation Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
US8703099B2 (en) * 2005-02-24 2014-04-22 Dr Pharma Nova, Llc Registry method and control system for DEA schedule II-V medicines
EP1813276A1 (en) 2006-01-27 2007-08-01 Euro-Celtique S.A. Tamper resistant dosage forms
CA2661302A1 (en) * 2006-08-16 2008-02-21 Auspex Pharmaceuticals, Inc. Preparation and utility of opioid analgesics
DK2345653T3 (da) 2007-05-01 2013-04-08 Concert Pharmaceuticals Inc Morphinanforbindelser
WO2011008636A1 (en) 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
JP6357098B2 (ja) * 2011-06-06 2018-07-11 ウオーターズ・テクノロジーズ・コーポレイシヨン 試料中の標的分析物を定量化するための組成物、方法およびキット

Also Published As

Publication number Publication date
EP2986612B1 (en) 2017-06-07
HU231191B1 (hu) 2021-08-30
WO2014170704A1 (en) 2014-10-23
US20160052931A1 (en) 2016-02-25
EP3312183B1 (en) 2020-06-17
US9447108B2 (en) 2016-09-20
EP2986612A1 (en) 2016-02-24
EP3312183A1 (en) 2018-04-25

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