HUP0501018A2 - Chiral resolution method for producing compounds useful in the synthesis of taxanes - Google Patents

Chiral resolution method for producing compounds useful in the synthesis of taxanes

Info

Publication number
HUP0501018A2
HUP0501018A2 HU0501018A HUP0501018A HUP0501018A2 HU P0501018 A2 HUP0501018 A2 HU P0501018A2 HU 0501018 A HU0501018 A HU 0501018A HU P0501018 A HUP0501018 A HU P0501018A HU P0501018 A2 HUP0501018 A2 HU P0501018A2
Authority
HU
Hungary
Prior art keywords
taxanes
synthesis
compounds useful
resolution method
producing compounds
Prior art date
Application number
HU0501018A
Other languages
English (en)
Inventor
James D Mcchesney
Herbert R Brinkman
Siead Zegar
David Baehr
Original Assignee
Napro Biotherapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics filed Critical Napro Biotherapeutics
Publication of HUP0501018A2 publication Critical patent/HUP0501018A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0501018A 2001-06-27 2002-06-27 Chiral resolution method for producing compounds useful in the synthesis of taxanes HUP0501018A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/894,811 US6653501B2 (en) 2001-06-27 2001-06-27 Chiral resolution method for producing compounds useful in the synthesis of taxanes
PCT/US2002/020733 WO2003002509A1 (en) 2001-06-27 2002-06-27 Chiral resolution method for producing compounds useful in the synthesis of taxanes

Publications (1)

Publication Number Publication Date
HUP0501018A2 true HUP0501018A2 (en) 2006-01-30

Family

ID=25403548

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0501018A HUP0501018A2 (en) 2001-06-27 2002-06-27 Chiral resolution method for producing compounds useful in the synthesis of taxanes

Country Status (8)

Country Link
US (1) US6653501B2 (hu)
EP (1) EP1412319A1 (hu)
JP (1) JP2005507859A (hu)
CN (1) CN1547567A (hu)
CA (1) CA2452109A1 (hu)
CZ (1) CZ2004136A3 (hu)
HU (1) HUP0501018A2 (hu)
WO (1) WO2003002509A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005243465B2 (en) * 2004-05-18 2011-08-25 F. Hoffmann-La Roche Ag Novel CIS-imidazolines
US7893278B2 (en) * 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
JP2009114065A (ja) * 2006-02-21 2009-05-28 Kaneka Corp （２ｒ，３ｒ）および（２ｓ，３ｓ）−３−フェニルイソセリン誘導体の製造法
JP6593328B2 (ja) * 2015-03-03 2019-10-23 東レ・ファインケミカル株式会社 ３−フェニルイソセリン誘導体の製造方法
CN108889276A (zh) * 2018-07-04 2018-11-27 林思思 一种人参皂苷专属分离硅胶固定相及制备方法
CN109400577B (zh) * 2019-01-07 2021-01-19 石药集团中奇制药技术（石家庄）有限公司 利伐沙班有关化合物及其制备方法和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
DK1001036T3 (da) 1992-01-15 2004-11-29 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
US6020174A (en) 1992-07-27 2000-02-01 The Board Of Governors For Higher Education Chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- (2R,3S)-Phenylisoserine
US5420337A (en) 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US5684175A (en) 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5948919A (en) 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
CA2155304C (en) 1993-02-05 2010-07-20 Charles Swindell Syntheses of paclitaxel, analogs and intermediates with variable a-ring side chains
US5602272A (en) 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
US5675025A (en) 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6107497A (en) 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5773629A (en) 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5973170A (en) 1996-09-25 1999-10-26 Napro Biotherapuetics, Inc. C-7 metal alkoxides of baccatin III
US5750737A (en) 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US6048990A (en) 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6066749A (en) 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6025516A (en) 1998-10-14 2000-02-15 Chiragene, Inc. Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
US6136999A (en) 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6143902A (en) 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof

Also Published As

Publication number Publication date
CN1547567A (zh) 2004-11-17
JP2005507859A (ja) 2005-03-24
EP1412319A1 (en) 2004-04-28
WO2003002509A1 (en) 2003-01-09
CZ2004136A3 (cs) 2004-07-14
US6653501B2 (en) 2003-11-25
CA2452109A1 (en) 2003-01-09
US20030045743A1 (en) 2003-03-06

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees