GB2405637B - Process for preparing of Paclitaxel - Google Patents

Process for preparing of Paclitaxel

Info

Publication number
GB2405637B
GB2405637B GB0500809A GB0500809A GB2405637B GB 2405637 B GB2405637 B GB 2405637B GB 0500809 A GB0500809 A GB 0500809A GB 0500809 A GB0500809 A GB 0500809A GB 2405637 B GB2405637 B GB 2405637B
Authority
GB
United Kingdom
Prior art keywords
paclitaxel
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0500809A
Other versions
GB2405637A (en
GB0500809D0 (en
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of GB0500809D0 publication Critical patent/GB0500809D0/en
Publication of GB2405637A publication Critical patent/GB2405637A/en
Application granted granted Critical
Publication of GB2405637B publication Critical patent/GB2405637B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB0500809A 2002-07-15 2003-07-15 Process for preparing of Paclitaxel Expired - Fee Related GB2405637B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216412.7A GB0216412D0 (en) 2002-07-15 2002-07-15 Chemical process
PCT/GB2003/003041 WO2004007473A1 (en) 2002-07-15 2003-07-15 Process for preparing of paclitaxel

Publications (3)

Publication Number Publication Date
GB0500809D0 GB0500809D0 (en) 2005-02-23
GB2405637A GB2405637A (en) 2005-03-09
GB2405637B true GB2405637B (en) 2006-02-22

Family

ID=9940483

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0216412.7A Ceased GB0216412D0 (en) 2002-07-15 2002-07-15 Chemical process
GB0500809A Expired - Fee Related GB2405637B (en) 2002-07-15 2003-07-15 Process for preparing of Paclitaxel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB0216412.7A Ceased GB0216412D0 (en) 2002-07-15 2002-07-15 Chemical process

Country Status (6)

Country Link
AP (1) AP2005003229A0 (en)
AU (1) AU2003254450A1 (en)
GB (2) GB0216412D0 (en)
RU (1) RU2326876C2 (en)
WO (1) WO2004007473A1 (en)
ZA (1) ZA200501234B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303077C (en) 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 Preparation process for synthesized taxane
CN101274924B (en) * 2007-03-27 2010-11-10 中国科学院大连化学物理研究所 Preparation for paclitaxel and derivatives thereof
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
CN104250235B (en) * 2014-09-24 2016-10-05 江苏红豆杉药业有限公司 A kind of preparation method of paclitaxel
CN105418543A (en) * 2015-12-01 2016-03-23 贵州大学 Method for extracting baccatin III reference substance from taxus chinensis plants
CN109438395A (en) * 2018-12-25 2019-03-08 重庆市碚圣医药科技股份有限公司 A kind of synthetic method and products thereof of Japanese yew alcohol intermediate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
WO1999045001A1 (en) * 1998-03-02 1999-09-10 Bristol-Myers Squibb Company Synthesis of paclitaxel baccatin iii by protecting the 7-hydroxyl using a strong base and an electrophile

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
WO1999045001A1 (en) * 1998-03-02 1999-09-10 Bristol-Myers Squibb Company Synthesis of paclitaxel baccatin iii by protecting the 7-hydroxyl using a strong base and an electrophile

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Am. Chem. Soc., 1998, Vol.120(49), Koichiro Morihira, pp.12980-1. *
Tetrahedron Letters, 1998, Vol.39(19), Holton, pp.2883-6. *
Tetrahedron, 1986, Vol.42(16), Gueritte-Vogelein, pp.4451-4460. *

Also Published As

Publication number Publication date
RU2005102395A (en) 2006-06-10
GB0216412D0 (en) 2002-08-21
GB2405637A (en) 2005-03-09
WO2004007473A1 (en) 2004-01-22
RU2326876C2 (en) 2008-06-20
AP2005003229A0 (en) 2005-03-31
GB0500809D0 (en) 2005-02-23
ZA200501234B (en) 2006-10-25
AU2003254450A1 (en) 2004-02-02

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20180715