HUP0402639A2 - Szubsztituált akriloil-disztamicin-származékokat és protein kináz (szerin/treonin kináz) inhibitorokat tartalmazó tumorellenes kombinációs készítmény és alkalmazása - Google Patents

Szubsztituált akriloil-disztamicin-származékokat és protein kináz (szerin/treonin kináz) inhibitorokat tartalmazó tumorellenes kombinációs készítmény és alkalmazása

Info

Publication number
HUP0402639A2
HUP0402639A2 HU0402639A HUP0402639A HUP0402639A2 HU P0402639 A2 HUP0402639 A2 HU P0402639A2 HU 0402639 A HU0402639 A HU 0402639A HU P0402639 A HUP0402639 A HU P0402639A HU P0402639 A2 HUP0402639 A2 HU P0402639A2
Authority
HU
Hungary
Prior art keywords
serine
inhibitors
kinase
distamycin derivatives
protein kinase
Prior art date
Application number
HU0402639A
Other languages
English (en)
Inventor
Maria Cristina Geroni
Camilla Fowst
Paolo Cozzi
Original Assignee
Pharmacia Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.
Publication of HUP0402639A2 publication Critical patent/HUP0402639A2/hu
Publication of HUP0402639A3 publication Critical patent/HUP0402639A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

A találmány tárgya akriloil-disztamicin-származékok, különösen az (l)általános képletű a-bróm- és a-klór-akriloil-disztamicin-származékokés protein kináz (szerin/treonin és tirozin kináz) inhibitoralkalmazása tumorok kezelésére. Kiterjed a találmány a kombinációkalkalmazására tumor áttétek kezelésére vagy megelőzésére, és tumorokkezelésére az angiogenézis gátlásával. Ó
HU0402639A 2002-01-02 2002-12-18 Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use HUP0402639A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075052 2002-01-02
PCT/EP2002/013092 WO2003055522A1 (en) 2002-01-02 2002-12-18 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors

Publications (2)

Publication Number Publication Date
HUP0402639A2 true HUP0402639A2 (hu) 2005-04-28
HUP0402639A3 HUP0402639A3 (en) 2012-02-28

Family

ID=8185508

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402639A HUP0402639A3 (en) 2002-01-02 2002-12-18 Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use

Country Status (24)

Country Link
US (1) US20060084612A1 (hu)
EP (1) EP1461083B1 (hu)
JP (1) JP2005516025A (hu)
KR (1) KR20040078118A (hu)
CN (1) CN1617744A (hu)
AT (1) ATE321572T1 (hu)
AU (1) AU2002352090B8 (hu)
BR (1) BR0215454A (hu)
CA (1) CA2472008C (hu)
CY (1) CY1105269T1 (hu)
DE (1) DE60210329T2 (hu)
DK (1) DK1461083T3 (hu)
ES (1) ES2263835T3 (hu)
HU (1) HUP0402639A3 (hu)
IL (2) IL162820A0 (hu)
MX (1) MXPA04006543A (hu)
NO (1) NO20043217L (hu)
NZ (1) NZ533854A (hu)
PL (1) PL371179A1 (hu)
PT (1) PT1461083E (hu)
RU (1) RU2328306C2 (hu)
SI (1) SI1461083T1 (hu)
WO (1) WO2003055522A1 (hu)
ZA (1) ZA200405290B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
SI1545553T1 (sl) * 2002-07-30 2011-09-30 Aeterna Zerntaris Gmbh Uporaba alkil fosfoholinov v kombinaciji s protitumornimi zdravili
PL1868599T3 (pl) * 2005-04-08 2010-04-30 Nerviano Medical Sciences Srl Przeciwnowotworowa kombinacja zawierająca podstawione akryloilowe pochodne dystamycyny oraz przeciwciała hamujące czynniki wzrostu lub ich receptory
WO2011123691A1 (en) 2010-03-31 2011-10-06 Keryx Biopharmaceuticals, Inc. Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274576B1 (en) * 1995-06-27 2001-08-14 The Henry Jackson Foundation For The Advancement Of Military Medicine Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents

Also Published As

Publication number Publication date
US20060084612A1 (en) 2006-04-20
MXPA04006543A (es) 2004-10-04
CN1617744A (zh) 2005-05-18
BR0215454A (pt) 2004-11-23
ES2263835T3 (es) 2006-12-16
AU2002352090A1 (en) 2003-07-15
CA2472008A1 (en) 2003-07-10
ATE321572T1 (de) 2006-04-15
SI1461083T1 (sl) 2006-08-31
AU2002352090B8 (en) 2008-06-19
RU2328306C2 (ru) 2008-07-10
IL162820A0 (en) 2005-11-20
CY1105269T1 (el) 2010-03-03
NZ533854A (en) 2007-05-31
JP2005516025A (ja) 2005-06-02
DE60210329T2 (de) 2006-11-30
WO2003055522A1 (en) 2003-07-10
KR20040078118A (ko) 2004-09-08
HUP0402639A3 (en) 2012-02-28
ZA200405290B (en) 2005-06-17
RU2004123641A (ru) 2005-06-10
CA2472008C (en) 2009-07-28
NO20043217L (no) 2004-07-30
AU2002352090B2 (en) 2008-05-15
EP1461083B1 (en) 2006-03-29
PT1461083E (pt) 2006-08-31
EP1461083A1 (en) 2004-09-29
DE60210329D1 (de) 2006-05-18
IL162820A (en) 2010-04-15
PL371179A1 (en) 2005-06-13
DK1461083T3 (da) 2006-07-10

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: NERVIANO MEDICAL SCIENCES S.R.L., IT

Free format text: FORMER OWNER(S): PHARMACIA ITALIA S.P.A., IT

FD9A Lapse of provisional protection due to non-payment of fees