HUP0401446A2 - Heterocondensated indole and heteroindole derivatives, the production and use thereof and pharmaceutical compositions containing them - Google Patents
Heterocondensated indole and heteroindole derivatives, the production and use thereof and pharmaceutical compositions containing themInfo
- Publication number
- HUP0401446A2 HUP0401446A2 HU0401446A HUP0401446A HUP0401446A2 HU P0401446 A2 HUP0401446 A2 HU P0401446A2 HU 0401446 A HU0401446 A HU 0401446A HU P0401446 A HUP0401446 A HU P0401446A HU P0401446 A2 HUP0401446 A2 HU P0401446A2
- Authority
- HU
- Hungary
- Prior art keywords
- nitrogen atom
- production
- indole
- heterocondensated
- pharmaceutical compositions
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003574 free electron Substances 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány új, (I) általános képletű, anellált, helyettesített indol-és heteroindolszármazékokkal, tautomerjeikkel, sztereoizomerjeikkel,ezek keverékeivel és gyógyszerészetileg alkalmazható sóikkal,előállításukkal és főleg daganatellenes gyógyszerként emlősöknél,különösen embernél történő alkalmazásukkal foglalkozik. A képletben A,B, C és D jelentése egymástól függetlenül nitrogénatom vagy szénatom,R2-R5 szubsztituensekkel helyettesítve; X jelentése karbonil-,szulfinil- vagy szulfonilcsoport; Y jelentése oxigénatom vagy R7szubsztituenssel helyettesített nitrogénatom; n jelentése 0 vagy l;amennyiben n=0, akkor Z jelentése R8 szubsztituenssel helyettesítettszénatom; amennyiben n=1, akkor Z jelentése nitrogénatom; R2, R3, R4 és R5jelentései egymástól függetlenül szabad elektronpár (amennyiben A, B,C vagy D jelentése nitrogénatom), illetve a leírásban részletezetthelyettesítők; R1, R6, R7 és R8 jelentései a leírásban részletezettsokféle helyet-tesítő. ÓThe invention deals with new, fused, substituted indole and heteroindole derivatives of general formula (I), their tautomers, stereoisomers, their mixtures and their pharmaceutically applicable salts, their production and their use mainly as antitumor drugs in mammals, especially in humans. In the formula, A, B, C and D independently represent a nitrogen atom or a carbon atom, replaced by R2-R5 substituents; X is carbonyl, sulfinyl or sulfonyl; Y is an oxygen atom or a nitrogen atom substituted with an R7 substituent; n is 0 or 1; if n=0, then Z is a carbon atom substituted with R8; if n=1, then Z is a nitrogen atom; The meanings of R2, R3, R4 and R5 independently of each other are free electron pairs (if A, B, C or D is a nitrogen atom), or the substituents detailed in the description; The meanings of R1, R6, R7 and R8 are various substituents detailed in the description. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10143079A DE10143079A1 (en) | 2001-09-03 | 2001-09-03 | Cyclic indole and heteroindole derivatives, their production and use as medicines |
| PCT/EP2002/009539 WO2003020731A1 (en) | 2001-09-03 | 2002-08-27 | Cyclic indole and heteroindole derivatives, the production and use thereof as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401446A2 true HUP0401446A2 (en) | 2004-11-29 |
| HUP0401446A3 HUP0401446A3 (en) | 2006-11-28 |
Family
ID=32239891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401446A HUP0401446A3 (en) | 2001-09-03 | 2002-08-27 | Heterocondensated indole and heteroindole derivatives, the production and use thereof and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1423393A1 (en) |
| JP (1) | JP2005508898A (en) |
| KR (1) | KR20040029463A (en) |
| CN (1) | CN1551885A (en) |
| AR (1) | AR036776A1 (en) |
| BR (1) | BR0212300A (en) |
| CA (1) | CA2458399A1 (en) |
| HU (1) | HUP0401446A3 (en) |
| IL (1) | IL160441A0 (en) |
| MX (1) | MXPA04002034A (en) |
| NO (1) | NO20040831L (en) |
| NZ (1) | NZ531642A (en) |
| PL (1) | PL370210A1 (en) |
| RU (1) | RU2004110412A (en) |
| ZA (1) | ZA200401290B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362891A (en) * | 2020-04-01 | 2020-07-03 | 杭州福斯特药业有限公司 | Production device and production method of acetyl tetrahydrofuran |
-
2002
- 2002-08-27 NZ NZ531642A patent/NZ531642A/en unknown
- 2002-08-27 MX MXPA04002034A patent/MXPA04002034A/en unknown
- 2002-08-27 BR BR0212300-2A patent/BR0212300A/en not_active IP Right Cessation
- 2002-08-27 IL IL16044102A patent/IL160441A0/en unknown
- 2002-08-27 JP JP2003525001A patent/JP2005508898A/en not_active Withdrawn
- 2002-08-27 RU RU2004110412/04A patent/RU2004110412A/en not_active Application Discontinuation
- 2002-08-27 CA CA002458399A patent/CA2458399A1/en not_active Abandoned
- 2002-08-27 KR KR10-2004-7003201A patent/KR20040029463A/en not_active Application Discontinuation
- 2002-08-27 HU HU0401446A patent/HUP0401446A3/en unknown
- 2002-08-27 PL PL02370210A patent/PL370210A1/en not_active Application Discontinuation
- 2002-08-27 EP EP02767436A patent/EP1423393A1/en not_active Withdrawn
- 2002-08-27 CN CNA028172639A patent/CN1551885A/en active Pending
- 2002-09-03 AR ARP020103329A patent/AR036776A1/en not_active Application Discontinuation
-
2004
- 2004-02-18 ZA ZA200401290A patent/ZA200401290B/en unknown
- 2004-02-25 NO NO20040831A patent/NO20040831L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ531642A (en) | 2005-01-28 |
| RU2004110412A (en) | 2005-03-20 |
| MXPA04002034A (en) | 2004-07-08 |
| CA2458399A1 (en) | 2003-03-13 |
| IL160441A0 (en) | 2004-07-25 |
| NO20040831L (en) | 2004-04-13 |
| EP1423393A1 (en) | 2004-06-02 |
| KR20040029463A (en) | 2004-04-06 |
| ZA200401290B (en) | 2004-03-23 |
| CN1551885A (en) | 2004-12-01 |
| PL370210A1 (en) | 2005-05-16 |
| JP2005508898A (en) | 2005-04-07 |
| BR0212300A (en) | 2004-10-13 |
| AR036776A1 (en) | 2004-10-06 |
| HUP0401446A3 (en) | 2006-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |