HUP0303688A2 - Propanolamino-tetralinok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Propanolamino-tetralinok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0303688A2
HUP0303688A2 HU0303688A HUP0303688A HUP0303688A2 HU P0303688 A2 HUP0303688 A2 HU P0303688A2 HU 0303688 A HU0303688 A HU 0303688A HU P0303688 A HUP0303688 A HU P0303688A HU P0303688 A2 HUP0303688 A2 HU P0303688A2
Authority
HU
Hungary
Prior art keywords
group
alk
hydrogen
atom
coo
Prior art date
Application number
HU0303688A
Other languages
English (en)
Inventor
Laura Barzaghi
Philippe R. Bovy
Roberto Cecchi
Tiziano Croci
Stefano Romagnano
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0303688A2 publication Critical patent/HUP0303688A2/hu
Publication of HUP0303688A3 publication Critical patent/HUP0303688A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány az (I) képletű vegyületekre - ahol R1 és R2 egymástólfüggetlenül hidrogénatomot benzilcsoportot, benzoilcsoportot egyCO(C1-C4-csoportot), egy CH2OCH3 csoportot, egy COO(C1-C4) Alkcsoportot vagy egy benziloxikarbonilcsoportot jelent; vagy Rl és R2együtt egy karbonil, egy di(C1-C4) Alk csoport metiléncsoportjátképezi, mely egy heterociklusos struktúrát képez az őket hordozóoxigén- és nitrogénatomokkal együtt; R3 hidrogént vagy egy (C1-C4) Alkcsoportot jelent; R4 hidroxicsoportot (C1-C4) alkoxicsoportot vagyNR5R6 csoportot jelent; R5 és R6 függetlenül egymástól hidrogénatomot,(C1-C4) alkilcsoportot, aril- vagy heteroarilcsoportot jelent adottesetben egy R7 csoporttal helyettesítve; vagy R5 és R6nitrogénatommal, mely hordozza őket egy 5-7 atomos telített vagytelítetlen gyűrűt képeznek; R7 hidrogén- vagy halogénatomot,hidroxilcsoportot, (C1-C4) Alk csoportot; (C1-C4) alkoxi, - COOH, -COO(C1-C4) Alk, -CN, -NH(C1-C4) Alk2 csoportot jelent; X jelentése Ovagy CH2; - és sóikra vagy szolvátjaikra, az azokat tartalmazógyógyszerkészítményekre, előállítási eljárásukra és szintézis-intermedierjeire vonatkozik. Ó
HU0303688A 2000-06-06 2001-05-29 Propanolaminotetralines, preparation thereof and pharmaceutical compositions containing same HUP0303688A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0007190A FR2809725B1 (fr) 2000-06-06 2000-06-06 Propanolaminotetralines, leur preparation et compositions pharmaceutiques en contenant
PCT/FR2001/001652 WO2001094307A1 (fr) 2000-06-06 2001-05-29 Propanolaminotetralines, leur preparation et compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
HUP0303688A2 true HUP0303688A2 (hu) 2004-03-01
HUP0303688A3 HUP0303688A3 (en) 2005-06-28

Family

ID=8850987

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303688A HUP0303688A3 (en) 2000-06-06 2001-05-29 Propanolaminotetralines, preparation thereof and pharmaceutical compositions containing same

Country Status (9)

Country Link
US (1) US7030160B2 (hu)
EP (1) EP1292572B1 (hu)
JP (1) JP4746253B2 (hu)
AT (1) ATE259784T1 (hu)
AU (1) AU2001274138A1 (hu)
DE (1) DE60102084T2 (hu)
FR (1) FR2809725B1 (hu)
HU (1) HUP0303688A3 (hu)
WO (1) WO2001094307A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833010B1 (fr) * 2001-12-05 2004-02-20 Sanofi Synthelabo Propanolaminomethyltetralines, leur preparation et compositions pharmaceutiques les contenant
EP2515890A4 (en) * 2009-12-21 2013-07-17 Univ Queensland NEURAL STIMULATION
WO2011112499A1 (en) * 2010-03-08 2011-09-15 Medicinova, Inc. Compositions, methods, and devices for the treatment of dysmenorrhea
WO2012119617A1 (en) 2011-03-10 2012-09-13 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Disinfection appliance and disinfection method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623941A1 (de) * 1986-07-16 1988-01-28 Bayer Ag Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel
US5254595A (en) * 1988-12-23 1993-10-19 Elf Sanofi Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
CN1202106A (zh) * 1995-09-21 1998-12-16 伊莱利利公司 选择性的β3肾上腺素能激动剂
TW375604B (en) * 1996-02-19 1999-12-01 Kissei Pharmaceutical 3,4-di-substituting phenyl-ethanolamine-tetrahydronaphthyl carboxylic amide derivatives
JPH09328459A (ja) * 1996-06-10 1997-12-22 Kissei Pharmaceut Co Ltd ３，４−ジ置換フェニルエタノールアミノテトラリン誘導体
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
AUPO565997A0 (en) * 1997-03-17 1997-04-10 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
JP4829418B2 (ja) * 2001-04-03 2011-12-07 キッセイ薬品工業株式会社 光学活性なハロヒドリン誘導体およびその使用方法

Also Published As

Publication number Publication date
EP1292572B1 (fr) 2004-02-18
HUP0303688A3 (en) 2005-06-28
JP2003535845A (ja) 2003-12-02
US20040034070A1 (en) 2004-02-19
WO2001094307A1 (fr) 2001-12-13
US7030160B2 (en) 2006-04-18
FR2809725B1 (fr) 2004-05-07
JP4746253B2 (ja) 2011-08-10
AU2001274138A1 (en) 2001-12-17
DE60102084T2 (de) 2004-12-09
DE60102084D1 (de) 2004-03-25
FR2809725A1 (fr) 2001-12-07
EP1292572A1 (fr) 2003-03-19
ATE259784T1 (de) 2004-03-15

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