HUP0203816A3 - Process of preparing tolterodine and analogues there of as well as intermediates - Google Patents

Process of preparing tolterodine and analogues there of as well as intermediates

Info

Publication number
HUP0203816A3
HUP0203816A3 HU0203816A HUP0203816A HUP0203816A3 HU P0203816 A3 HUP0203816 A3 HU P0203816A3 HU 0203816 A HU0203816 A HU 0203816A HU P0203816 A HUP0203816 A HU P0203816A HU P0203816 A3 HUP0203816 A3 HU P0203816A3
Authority
HU
Hungary
Prior art keywords
analogues
intermediates
well
preparing tolterodine
tolterodine
Prior art date
Application number
HU0203816A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of HUP0203816A2 publication Critical patent/HUP0203816A2/hu
Publication of HUP0203816A3 publication Critical patent/HUP0203816A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0203816A 1999-12-30 2000-12-22 Process of preparing tolterodine and analogues there of as well as intermediates HUP0203816A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904850A SE9904850D0 (sv) 1999-12-30 1999-12-30 Novel process and intermediates
PCT/SE2000/002662 WO2001049649A1 (en) 1999-12-30 2000-12-22 Process of preparing tolterodine and analogues there of as well as intermediates prepared in the process

Publications (2)

Publication Number Publication Date
HUP0203816A2 HUP0203816A2 (hu) 2003-03-28
HUP0203816A3 true HUP0203816A3 (en) 2004-12-28

Family

ID=20418365

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203816A HUP0203816A3 (en) 1999-12-30 2000-12-22 Process of preparing tolterodine and analogues there of as well as intermediates

Country Status (29)

Country Link
US (1) US6310248B2 (enExample)
EP (2) EP1242361B1 (enExample)
JP (1) JP2003519207A (enExample)
KR (1) KR20020062669A (enExample)
CN (1) CN1209342C (enExample)
AR (1) AR027138A1 (enExample)
AT (1) ATE282019T1 (enExample)
AU (1) AU782796B2 (enExample)
BR (1) BR0016785A (enExample)
CA (1) CA2392832A1 (enExample)
CZ (1) CZ20022255A3 (enExample)
DE (1) DE60015799T2 (enExample)
DK (1) DK1242361T3 (enExample)
EE (1) EE200200325A (enExample)
ES (1) ES2228658T3 (enExample)
HU (1) HUP0203816A3 (enExample)
IL (1) IL150275A0 (enExample)
MX (1) MXPA02006415A (enExample)
MY (1) MY118906A (enExample)
NO (1) NO20023189L (enExample)
NZ (1) NZ519079A (enExample)
PE (1) PE20011123A1 (enExample)
PL (1) PL355947A1 (enExample)
PT (1) PT1242361E (enExample)
SE (1) SE9904850D0 (enExample)
SK (1) SK9392002A3 (enExample)
TW (1) TWI225476B (enExample)
WO (1) WO2001049649A1 (enExample)
ZA (1) ZA200204066B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
US6703504B2 (en) 2002-02-11 2004-03-09 Clarke Slemon Conformationally constrained compounds as dendrimer cores
WO2003064501A1 (en) * 2002-01-31 2003-08-07 Clarke Slemon Conformationally restricted compounds as dendrimer cores
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
ITMI20031354A1 (it) * 2003-07-02 2005-01-03 Istituto Di Chimica Biomolecolare D El Cnr Sezione Sintesis enantioselettiva di composti enantiomericamente arricchiti.
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
ITMI20040616A1 (it) * 2004-03-30 2004-06-30 Dinamite Dipharma S P A In For Processo per la preparazione di tolterodina e suoi intermedi
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
ITMI20041920A1 (it) * 2004-10-11 2005-01-11 Chemi Spa Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina
JP4513535B2 (ja) * 2004-12-03 2010-07-28 住友化学株式会社 トルテロジンの製造方法
US20080045602A1 (en) * 2004-12-24 2008-02-21 Casar Renata T Process for Preparation of 3-(2-Hydroxy-5Methylphenyl)-N, N-Disopropyl-3-Phenylpropylamine
US7528267B2 (en) * 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
ES2268987B1 (es) 2005-08-05 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de 3,3-difenilpropilaminas.
KR100647068B1 (ko) 2005-09-15 2006-11-23 하나제약 주식회사 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법
KR100686351B1 (ko) * 2006-01-12 2007-02-22 주식회사 카이로제닉스 톨테로딘 라세미체의 제조방법
DK2029567T3 (da) 2006-05-24 2010-11-29 Pfizer Ltd Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater
SI2027103T1 (sl) 2006-06-12 2014-07-31 Ucb Pharma Gmbh Novi kiralni vmesni produkt, postopek za njegovo proizvodnjo in njega uporaba pri proizvodnji tolterodina, fesoterodina ali njih aktivnega metabolita
KR100717361B1 (ko) * 2006-08-07 2007-05-11 주식회사 카이로제닉스 톨테로딘 라세미체 및 이의 중간체의 제조방법
US8871275B2 (en) 2007-08-08 2014-10-28 Inventia Healthcare Private Limited Extended release compositions comprising tolterodine
HRP20140640T1 (hr) 2008-08-19 2014-11-21 Xenoport, Inc. Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe
CA2748250A1 (en) 2008-12-24 2010-07-01 Daiichi Sankyo Company, Limited Indanyl compounds
MX2011006655A (es) 2008-12-24 2011-07-29 Daiichi Sankyo Co Ltd Compuestos de anima ciclica.
KR101275984B1 (ko) * 2010-10-18 2013-06-18 경기대학교 산학협력단 광학활성을 갖는 크로만계 유도체 및 이의 제조방법
WO2012063843A1 (ja) * 2010-11-09 2012-05-18 株式会社カネカ ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
EP2476665A1 (en) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
WO2012098044A1 (en) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
PE20150928A1 (es) 2011-06-20 2015-06-26 Lundbeck & Co As H 1-piperazino-3-fenil-indanos deuterados para el tratamiento de esquizofrenia
CN103159657B (zh) * 2011-12-08 2016-06-29 重庆华邦胜凯制药有限公司 一种定向合成不饱和共轭醇的方法
AR094054A1 (es) * 2012-12-19 2015-07-08 H Lundbeck As 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma
KR101380982B1 (ko) 2013-04-29 2014-04-10 경기대학교 산학협력단 광학활성을 갖는 크로만-2-올 유도체 및 이의 제조방법
WO2017137955A1 (en) 2016-02-14 2017-08-17 Celestis Pharmaceuticals Pvt. Ltd. Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
US20210282443A1 (en) * 2016-07-12 2021-09-16 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) * 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
ZA969363B (en) 1995-11-08 1997-11-18 Smithkline Beecham Corp An improved process for preparing aromatic ring-fused cyclopentane derivatives.
KR20000057548A (ko) * 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines

Also Published As

Publication number Publication date
NO20023189D0 (no) 2002-07-01
EP1242361A1 (en) 2002-09-25
AU2719001A (en) 2001-07-16
PL355947A1 (en) 2004-05-31
MY118906A (en) 2005-02-28
WO2001049649A1 (en) 2001-07-12
KR20020062669A (ko) 2002-07-26
EP1496045A2 (en) 2005-01-12
CN1209342C (zh) 2005-07-06
TWI225476B (en) 2004-12-21
DE60015799D1 (de) 2004-12-16
EE200200325A (et) 2003-08-15
ATE282019T1 (de) 2004-11-15
AU782796B2 (en) 2005-09-01
PE20011123A1 (es) 2001-11-09
HK1052000A1 (en) 2003-08-29
ZA200204066B (en) 2003-07-30
EP1496045A3 (en) 2005-03-30
ES2228658T3 (es) 2005-04-16
JP2003519207A (ja) 2003-06-17
HUP0203816A2 (hu) 2003-03-28
IL150275A0 (en) 2002-12-01
BR0016785A (pt) 2002-09-24
PT1242361E (pt) 2005-01-31
EP1242361B1 (en) 2004-11-10
US20010016669A1 (en) 2001-08-23
CN1414944A (zh) 2003-04-30
NZ519079A (en) 2004-02-27
CA2392832A1 (en) 2001-07-12
AR027138A1 (es) 2003-03-12
DE60015799T2 (de) 2005-12-15
MXPA02006415A (es) 2002-11-29
NO20023189L (no) 2002-07-04
SE9904850D0 (sv) 1999-12-30
SK9392002A3 (en) 2003-01-09
US6310248B2 (en) 2001-10-30
CZ20022255A3 (cs) 2002-11-13
DK1242361T3 (da) 2005-02-14

Similar Documents

Publication Publication Date Title
HUP0203816A3 (en) Process of preparing tolterodine and analogues there of as well as intermediates
HUP0200898A2 (en) Derivatives of venlafaxine and methods of preparing and using the same
PL357302A1 (en) Premixes and method of preparing adhesives and caulks from premixes
PL340109A1 (en) Method of obtaining analogues of nucleosides
GB0112699D0 (en) Process for the preparation of prostglandins and analogues thereof
GB0106310D0 (en) Process for the preparation of ethyl acetate
EG23819A (en) Method for preparing of l-phenylephrine-hydrochloride
IL159632A0 (en) Process and intermediates to prepare latanoprost
PL368600A1 (en) Process for the preparation of tolterodine
SG118060A1 (en) Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof
PL352765A1 (en) Production of aliphatic fluorocarbons
AU1706802A (en) A process for the preparation of iopamidol and the new intermediates therein
EP1406855A4 (en) NOVEL PROCESS FOR THE PREPARATION OF RAC-BICALUTAMIDE AND INTERMEDIATE PRODUCTS THEREOF
HUP0203315A3 (en) Process and intermediates for the preparation of isoxazolecaroxamides and analogues
HUP0104278A3 (en) Novel process for the preparation of 7-azaindolyl-3-carboxylic acid and 7-azaindol and their intermediates
HUP0100356A3 (en) Process for preparation and purification of tramadol
HUP0004582A3 (en) Novel stereoselective processes for the preparation of gabapentin analogues
HUP0203543A3 (en) Process to prepare aryltriazolinones and novel intermediates thereto
PL341752A1 (en) Method of obtaining aryloamino hydroxyantraquinones
AU9372601A (en) Process for preparing discodermolide and analogues thereof
IL149531A0 (en) Ethers of o-desmethyl venlafaxine
HUP0302144A3 (en) Process of preparation of aliphatic amines
HUP0001327A3 (en) Process for preparing of cyclic amides and their intermediates
PL338405A1 (en) Method of obtaining 2-quinoxalincarboxylic acid
HU9904575D0 (en) Process for preparation of n-alkoxy-methyl-acidamides

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees