HUP0202738A2 - Ló herpeszvírus hőérzékeny mutánsa és az abból készített élő oltóanyag - Google Patents

Ló herpeszvírus hőérzékeny mutánsa és az abból készített élő oltóanyag Download PDF

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Publication number
HUP0202738A2
HUP0202738A2 HU0202738A HUP0202738A HUP0202738A2 HU P0202738 A2 HUP0202738 A2 HU P0202738A2 HU 0202738 A HU0202738 A HU 0202738A HU P0202738 A HUP0202738 A HU P0202738A HU P0202738 A2 HUP0202738 A2 HU P0202738A2
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ehv
virus
mutant
days
vaccine
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HU0202738A
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English (en)
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Jay R. Patel
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Akzo Nobel N.V.
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Publication of HUP0202738A2 publication Critical patent/HUP0202738A2/hu
Publication of HUP0202738A3 publication Critical patent/HUP0202738A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/27—Equine rhinopneumonitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16763—Methods of inactivation or attenuation by chemical treatment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgya ló vetélési vírus (EHV-1) mutánsa, amely hőérzékenya gazdaállat testhőmérsékletén, közelebbről 38,5 °C-on vagymagasabban. A hőérzékeny mutáns alkalmazható vakcinálásban fogékonyállatok EHV-1-fertőzés elleni védelmére. A találmány tárgyát képeziktovábbá a mutánsból származó élő oltóanyagok. Ó

Claims (5)

  1. - 22 - .· ···. .· : .··.
    ···· ··· ···· ··· ··
    Szabadalmi igénypontok
    1. Ló vetélési vírus (EHV-1) hőérzékeny (Ts) mutánsa, amely a V99061001 lajstromszámon az ECACC-nál letétbe helyezett EHV-1 Ts-mutáns, vagy annak utóda.
  2. 2. Gyógyászati készítmény, amely 1. igénypont szerinti hőérzékeny mutánst és gyógyászatilag elfogadható hordozót vagy hordozóeszközt tartalmaz.
  3. 3. Oltóanyag EHV-l-fertőzések megelőzésére és/vagy kezelésre lófélékben, amely 1. igénypont szerinti hőérzékeny mutáns vírust és gyógyászatilag elfogadható hordozót vagy oldószert tartalmaz.
  4. 4. Az 1. igénypont szerinti hőérzékeny mutáns alkalmazása EHV-l-fertőzések megelőzésére és/vagy kezelésére alkalmas oltóanyag gyártásában.
  5. 5. Eljárás állat EHV-1-fertőzés elleni immunizálására, azzal jellemezve, hogy az állatnak 4. igénypont szerinti oltóanyagot adunk be.
    A meghatalmazott:
    DANUBIA
    szabadalmi ügyvivőjelölt ν'
HU0202738A 1999-09-10 2000-09-11 Equine herpes virus temperature sensitive mutant and live vaccine thereof HUP0202738A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202933 1999-09-10
PCT/EP2000/008944 WO2001017553A1 (en) 1999-09-10 2000-09-11 Equine herpes virus temperature sensitive mutant and live vaccine thereof

Publications (2)

Publication Number Publication Date
HUP0202738A2 true HUP0202738A2 (hu) 2002-12-28
HUP0202738A3 HUP0202738A3 (en) 2003-12-29

Family

ID=8240619

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202738A HUP0202738A3 (en) 1999-09-10 2000-09-11 Equine herpes virus temperature sensitive mutant and live vaccine thereof

Country Status (8)

Country Link
EP (1) EP1216054A1 (hu)
JP (1) JP2004532601A (hu)
AU (1) AU778157B2 (hu)
CA (1) CA2383980A1 (hu)
HU (1) HUP0202738A3 (hu)
MX (1) MXPA02002566A (hu)
RU (1) RU2252253C2 (hu)
WO (1) WO2001017553A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1129722A1 (en) 2000-02-17 2001-09-05 Boehringer Ingelheim Vetmedica Gmbh gM-negative EHV-mutants
AR040601A1 (es) 2002-07-19 2005-04-13 Boehringer Ingelheim Vetmed Mutantes ehv negativos de gm sin elementos heterologos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110433A (en) * 1976-04-23 1978-08-29 Philips Roxane, Inc. Equine rhinopneumonitis virus
US5972666A (en) * 1996-07-26 1999-10-26 G. D. Searle & Co. Assembly-deficient herpesvirus vaccine
US5853715A (en) * 1996-08-16 1998-12-29 Bayer Corporation Cross-protective equine herpesvirus preparations and method of making and using the same

Also Published As

Publication number Publication date
MXPA02002566A (es) 2002-10-23
WO2001017553A1 (en) 2001-03-15
RU2002109231A (ru) 2004-02-27
CA2383980A1 (en) 2001-03-15
RU2252253C2 (ru) 2005-05-20
HUP0202738A3 (en) 2003-12-29
AU778157B2 (en) 2004-11-18
EP1216054A1 (en) 2002-06-26
JP2004532601A (ja) 2004-10-28
AU1271101A (en) 2001-04-10

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