HUP0103992A2 - Pregnane glucuronides, process for their production and pharmaceutical compositions containing them - Google Patents

Pregnane glucuronides, process for their production and pharmaceutical compositions containing them

Info

Publication number
HUP0103992A2
HUP0103992A2 HU0103992A HUP0103992A HUP0103992A2 HU P0103992 A2 HUP0103992 A2 HU P0103992A2 HU 0103992 A HU0103992 A HU 0103992A HU P0103992 A HUP0103992 A HU P0103992A HU P0103992 A2 HUP0103992 A2 HU P0103992A2
Authority
HU
Hungary
Prior art keywords
glucuronides
pregnane
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0103992A
Other languages
Hungarian (hu)
Inventor
Michael David Collini
Christopher Paul Miller
Bach Dinh Tran
Original Assignee
American Home Products Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp. filed Critical American Home Products Corp.
Publication of HUP0103992A2 publication Critical patent/HUP0103992A2/en
Publication of HUP0103992A3 publication Critical patent/HUP0103992A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A tal lm ny 5a-pregn n-3b,20S,21-triol-20-O-b-D-glükuronidra és 5a-pregn n-3b,20R-diol-20-O-b-D-glükuronidra és ezek gyógy - szatilagelfogadható sóira, ezek elő llít s ra, valamint a vegyületekettartalmazó gyógyszerkészítményekre vonatkozik. Fenti vegyületekmenstru ciót megelőző kezelésre, r kbetegségek és k"zpontiidegrendszeri rendellenességek kezelésére vagy g tl s raalkalmazhatók. ÓThese include 5a-pregn n-3b,20S,21-triol-20-O-b-D-glucuronide and 5a-pregn n-3b,20R-diol-20-O-b-D-glucuronide and their medicinally acceptable salts, these are produced and pharmaceutical preparations containing the compounds. The above compounds can be used for premenstrual treatment, for the treatment of cancer diseases and central nervous system disorders, or for gtls.

HU0103992A 1998-10-13 1999-10-07 Pregnane glucuronides, process for their production and pharmaceutical compositions containing them HUP0103992A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17034298A 1998-10-13 1998-10-13
PCT/US1999/023467 WO2000021977A1 (en) 1998-10-13 1999-10-07 Pregnane glucuronides

Publications (2)

Publication Number Publication Date
HUP0103992A2 true HUP0103992A2 (en) 2002-04-29
HUP0103992A3 HUP0103992A3 (en) 2002-12-28

Family

ID=22619512

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103992A HUP0103992A3 (en) 1998-10-13 1999-10-07 Pregnane glucuronides, process for their production and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP1121376A1 (en)
JP (1) JP2002527448A (en)
KR (1) KR20010080102A (en)
CN (1) CN1330659A (en)
AR (1) AR020778A1 (en)
AU (1) AU751708B2 (en)
BR (1) BR9914521A (en)
CA (1) CA2346693A1 (en)
CZ (1) CZ20011343A3 (en)
EA (1) EA200100437A1 (en)
HU (1) HUP0103992A3 (en)
IL (1) IL142441A0 (en)
NO (1) NO20011825L (en)
PL (1) PL347270A1 (en)
TW (1) TW499435B (en)
WO (1) WO2000021977A1 (en)
ZA (1) ZA200103012B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104423D0 (en) * 2001-12-27 2001-12-27 Umecrine Ab Pregnane steroids and their use in the treatment of CNS disorders
KR100440607B1 (en) * 2001-12-28 2004-07-15 주식회사 엘컴사이언스 Pregnan glycoside compounds and preventives and remedies of neurodegenerative disease containing them as active ingredients

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2029011B (en) * 1978-09-01 1983-02-02 Coulson W Use of a synthetic bifunctional ligand for the immunimetric determination of the concentration ratio of two solutes

Also Published As

Publication number Publication date
EP1121376A1 (en) 2001-08-08
CA2346693A1 (en) 2000-04-20
CZ20011343A3 (en) 2002-04-17
EA200100437A1 (en) 2001-10-22
NO20011825L (en) 2001-06-05
WO2000021977A1 (en) 2000-04-20
IL142441A0 (en) 2002-03-10
AU751708B2 (en) 2002-08-22
BR9914521A (en) 2001-06-26
PL347270A1 (en) 2002-03-25
JP2002527448A (en) 2002-08-27
AU6511599A (en) 2000-05-01
ZA200103012B (en) 2002-07-11
KR20010080102A (en) 2001-08-22
HUP0103992A3 (en) 2002-12-28
AR020778A1 (en) 2002-05-29
NO20011825D0 (en) 2001-04-10
CN1330659A (en) 2002-01-09
TW499435B (en) 2002-08-21

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