HUP0103077A2 - New benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
New benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HUP0103077A2 HUP0103077A2 HU0103077A HUP0103077A HUP0103077A2 HU P0103077 A2 HUP0103077 A2 HU P0103077A2 HU 0103077 A HU0103077 A HU 0103077A HU P0103077 A HUP0103077 A HU P0103077A HU P0103077 A2 HUP0103077 A2 HU P0103077A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- straight
- branched
- aryl group
- carbon
- Prior art date
Links
- 150000007658 benzothiadiazines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
A találmány szerinti (I) általános képletű vegyületek - a képletben R1jelentése hidroxilcsoport, RCO-O- vagy RCO-NRa- általános képletűcsoport, R2 jelentése hidrogénatom, halogénatom vagy hidroxilcsoport,R'CO-O vagy R'CO-NR'a- általános képletű csoport, R és R' jelentéseazonosan vagy eltérően egyenes vagy elágazó szénláncú 1-6 szénatomosalkilcsoport, amely adottesetben arilcsoporttal van szubsztituálva,egyenes vagy elágazó szénláncú 2-6 szénatomos alkenilcsoport, amelyadott esetben arilcsoporttal van szubsztituálva, egyenes vagy elágazószénláncú 1-6 szénatomos perhalogénalkilcsoport, 3-7 szénatomoscikloalkilcsoport, adamantilcsoport, arilcsoport vagyheteroarilcsoport, Ra és R'a jelentése azonosan vagy eltérőenhidrogénatom vagy egyenes vagy elágazó szénláncú 1-6 szénatomosalkilcsoport, egyenes vagy elágazó szénláncú 1-6 szénatomosperhalogénalkilcsoport, egyenes vagy elágazó szénláncú 1-6 szénatomosacilcsoport, arilcsoport, vagy heteroarilcsoport és izomerjeik,valamint gyógyászatilag elfogadható savval vagy bázissal alkotottaddíciós sóik AMPA modulátor hatásuk következtébengyógyszerkészítmények hatóanyagaként alkalmazhatók. ÓThe compounds of the general formula (I) according to the invention - in the formula, R1 means a hydroxyl group, RCO-O- or RCO-NRa- a group of the general formula, R2 means a hydrogen atom, a halogen atom or a hydroxyl group, R'CO-O or R'CO-NR'a- a group of the formula, R and R' are the same or different straight or branched C1-C6 alkyl groups, optionally substituted with an aryl group, straight or branched C2-C6 alkenyl groups, optionally substituted with an aryl group, straight or branched C1-C6 perhaloalkyl groups, 3-7 carbon atom cycloalkyl group, adamantyl group, aryl group or heteroaryl group, Ra and R'a are the same or different hydrogen atom or straight or branched carbon 1-6 alkyl group, straight or branched carbon 1-6 perhaloalkyl group, straight or branched carbon 1-6 acyl group, aryl group, or heteroaryl group and their isomers, as well as their addition salts formed with a pharmaceutically acceptable acid or base, can be used as active ingredients in pharmaceutical preparations due to their AMPA modulator effect. HE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0009916A FR2812291B1 (en) | 2000-07-28 | 2000-07-28 | NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0103077D0 HU0103077D0 (en) | 2001-10-28 |
| HUP0103077A2 true HUP0103077A2 (en) | 2002-05-29 |
| HUP0103077A3 HUP0103077A3 (en) | 2002-11-28 |
Family
ID=8853020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103077A HUP0103077A3 (en) | 2000-07-28 | 2001-07-27 | New benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6635635B2 (en) |
| EP (1) | EP1176148B1 (en) |
| JP (1) | JP3643325B2 (en) |
| KR (2) | KR100544590B1 (en) |
| CN (1) | CN1147494C (en) |
| AR (1) | AR030002A1 (en) |
| AT (1) | ATE248843T1 (en) |
| AU (1) | AU779422B2 (en) |
| BR (1) | BR0103070A (en) |
| CA (1) | CA2354123C (en) |
| DE (1) | DE60100690T2 (en) |
| DK (1) | DK1176148T3 (en) |
| EA (1) | EA004682B1 (en) |
| ES (1) | ES2206386T3 (en) |
| FR (1) | FR2812291B1 (en) |
| HK (1) | HK1042094B (en) |
| HU (1) | HUP0103077A3 (en) |
| MX (1) | MXPA01007558A (en) |
| NO (1) | NO20013710L (en) |
| NZ (1) | NZ513203A (en) |
| PL (1) | PL348936A1 (en) |
| PT (1) | PT1176148E (en) |
| SI (1) | SI1176148T1 (en) |
| ZA (1) | ZA200106203B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823753B1 (en) * | 2001-04-18 | 2004-07-16 | Servier Lab | NEW PROCESS FOR THE SYNTHESIS OF (3AS) -5,5-DIOXO-2,3,3A, 4-TETRAHYDRO-1H-PYRROLO [2,1-C] [1,2,4] BENZOTHIADIAZINE |
| FR2833956B1 (en) | 2001-12-21 | 2004-01-30 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2833955B1 (en) * | 2001-12-21 | 2004-01-30 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| JP4818114B2 (en) * | 2003-05-16 | 2011-11-16 | メルク シャープ エンド ドーム リミテッド | Cyclohexyl sulfones as γ-secretase inhibitors |
| FR2856064B1 (en) * | 2003-06-13 | 2005-08-19 | Servier Lab | NOVEL BENZOTHIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2879201B1 (en) * | 2004-12-10 | 2007-02-16 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| WO2007023907A1 (en) * | 2005-08-24 | 2007-03-01 | Transcu Ltd. | Refrigeration-type electrode structure for iontophoresis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1255216B (en) * | 1962-06-05 | 1967-11-30 | Bayer Ag | Process for the production of azo dyes and their metal complex compounds |
| US3471483A (en) * | 1967-11-09 | 1969-10-07 | American Home Prod | 1 - substituted - 2,3,3a - 4 - tetrahydro - 1h-pyrrolo(2,1 - c)(1,2,4)benzothiadiazine,5,5-dioxide |
| JP3061631B2 (en) * | 1989-10-11 | 2000-07-10 | 山之内製薬株式会社 | Novel heterocyclic compound and method for producing the same |
| JPH06192272A (en) * | 1992-12-24 | 1994-07-12 | Japan Tobacco Inc | New triazolobenzothiadiazine and triazolobenzothiadiazepine derivative |
| FR2722502B1 (en) * | 1994-07-12 | 1996-08-23 | Adir | NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| CA2320354A1 (en) * | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
-
2000
- 2000-07-28 FR FR0009916A patent/FR2812291B1/en not_active Expired - Fee Related
-
2001
- 2001-07-10 SI SI200130028T patent/SI1176148T1/en unknown
- 2001-07-10 ES ES01401839T patent/ES2206386T3/en not_active Expired - Lifetime
- 2001-07-10 AT AT01401839T patent/ATE248843T1/en not_active IP Right Cessation
- 2001-07-10 PT PT01401839T patent/PT1176148E/en unknown
- 2001-07-10 DE DE60100690T patent/DE60100690T2/en not_active Expired - Fee Related
- 2001-07-10 DK DK01401839T patent/DK1176148T3/en active
- 2001-07-10 EP EP01401839A patent/EP1176148B1/en not_active Expired - Lifetime
- 2001-07-26 MX MXPA01007558A patent/MXPA01007558A/en not_active Application Discontinuation
- 2001-07-26 PL PL01348936A patent/PL348936A1/en unknown
- 2001-07-26 JP JP2001225821A patent/JP3643325B2/en not_active Expired - Fee Related
- 2001-07-26 CA CA002354123A patent/CA2354123C/en not_active Expired - Fee Related
- 2001-07-27 NO NO20013710A patent/NO20013710L/en not_active Application Discontinuation
- 2001-07-27 EA EA200100725A patent/EA004682B1/en not_active IP Right Cessation
- 2001-07-27 KR KR1020010045411A patent/KR100544590B1/en not_active IP Right Cessation
- 2001-07-27 CN CNB01124352XA patent/CN1147494C/en not_active Expired - Fee Related
- 2001-07-27 AR ARP010103587A patent/AR030002A1/en not_active Application Discontinuation
- 2001-07-27 NZ NZ513203A patent/NZ513203A/en unknown
- 2001-07-27 ZA ZA200106203A patent/ZA200106203B/en unknown
- 2001-07-27 AU AU57692/01A patent/AU779422B2/en not_active Ceased
- 2001-07-27 HU HU0103077A patent/HUP0103077A3/en unknown
- 2001-07-27 US US09/916,479 patent/US6635635B2/en not_active Expired - Fee Related
- 2001-07-30 BR BR0103070-1A patent/BR0103070A/en not_active Application Discontinuation
-
2002
- 2002-05-31 HK HK02104113.2A patent/HK1042094B/en not_active IP Right Cessation
-
2005
- 2005-10-27 KR KR1020050102053A patent/KR20050108327A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |