HUP0100865A2 - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use - Google Patents
Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their useInfo
- Publication number
- HUP0100865A2 HUP0100865A2 HU0100865A HUP0100865A HUP0100865A2 HU P0100865 A2 HUP0100865 A2 HU P0100865A2 HU 0100865 A HU0100865 A HU 0100865A HU P0100865 A HUP0100865 A HU P0100865A HU P0100865 A2 HUP0100865 A2 HU P0100865A2
- Authority
- HU
- Hungary
- Prior art keywords
- meta
- derivatives
- pharmaceutical compositions
- benzoic acid
- integrin antagonists
- Prior art date
Links
- 102000006495 integrins Human genes 0.000 title abstract 3
- 108010044426 integrins Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000005415 aminobenzoic acids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
A találmány av<3 integrin antagonistákként felhasználható (I) általános képletű vegyületekre - amelyek képletében X és Yjelentése azonos vagy egymástól eltérő halogénatom; és R jelentésehidrogénatom vagy 1-10 szénatomos alkilcsoport - és gyógyszerészetilegelfogadható sóikra, ilyen vegyületeket tartalmazógyógyszerkészítményekre, valamint a vegyületeknek av<3 integrin általmediált betegségek kezelésére szolgáló gyógyszerkészítményekelőállítására történő alkalmazására vonatkozik. ÓThe invention can be used as av<3 integrin antagonists for compounds of general formula (I) - in the formula of which X and Y mean the same or different halogen atoms; and R represents a hydrogen atom or an alkyl group with 1-10 carbon atoms - and refers to their pharmaceutically acceptable salts, pharmaceutical preparations containing such compounds, and the use of the compounds for the production of pharmaceutical preparations for the treatment of diseases mediated by av<3 integrin. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3427098A | 1998-03-04 | 1998-03-04 | |
| PCT/US1999/003281 WO1999044994A1 (en) | 1998-03-04 | 1999-02-22 | Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100865A2 true HUP0100865A2 (en) | 2001-08-28 |
| HUP0100865A3 HUP0100865A3 (en) | 2001-11-28 |
Family
ID=21875345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100865A HUP0100865A3 (en) | 1998-03-04 | 1999-02-22 | Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1060164A1 (en) |
| JP (1) | JP2002505323A (en) |
| KR (1) | KR20010041584A (en) |
| CN (1) | CN1214011C (en) |
| AP (1) | AP1244A (en) |
| AR (1) | AR018139A1 (en) |
| AU (1) | AU753230B2 (en) |
| BG (1) | BG104740A (en) |
| BR (1) | BR9908470A (en) |
| CA (1) | CA2322207A1 (en) |
| EA (1) | EA200000804A1 (en) |
| EE (1) | EE200000506A (en) |
| GE (1) | GEP20033118B (en) |
| HR (1) | HRP20000574A2 (en) |
| HU (1) | HUP0100865A3 (en) |
| ID (1) | ID25591A (en) |
| IL (1) | IL137653A0 (en) |
| IS (1) | IS5582A (en) |
| MY (1) | MY123908A (en) |
| NO (1) | NO315703B1 (en) |
| NZ (1) | NZ506598A (en) |
| OA (1) | OA11530A (en) |
| PL (1) | PL342726A1 (en) |
| SK (1) | SK13002000A3 (en) |
| TR (1) | TR200002542T2 (en) |
| UA (1) | UA71906C2 (en) |
| WO (1) | WO1999044994A1 (en) |
| YU (1) | YU52000A (en) |
| ZA (1) | ZA994406B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| AU2001248553A1 (en) | 2000-04-17 | 2001-10-30 | Celltech R And D Limited | Enamine derivatives as cell adhesion molecules |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| US6921767B2 (en) * | 2000-06-15 | 2005-07-26 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives |
| JP2004505110A (en) | 2000-08-02 | 2004-02-19 | セルテック アール アンド ディ リミテッド | 3-position substituted isoquinolin-1-yl derivative |
| EP1572210A1 (en) * | 2002-12-20 | 2005-09-14 | Pharmacia Corporation | The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| US20070015814A1 (en) * | 2005-06-10 | 2007-01-18 | Ernest Kun | Parp Modulators and Treatment of Cancer |
| WO2008108944A2 (en) | 2007-03-01 | 2008-09-12 | Mallinckrodt Inc. | Integrated photoactive small molecules and uses thereof |
| JP4792124B1 (en) * | 2010-11-15 | 2011-10-12 | エフイートレード株式会社 | Method for molding protective film for vehicle and method for manufacturing protective film for vehicle |
| US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| JP6215324B2 (en) | 2012-07-18 | 2017-10-18 | セントルイス ユニバーシティ | Beta amino acid derivatives as integrin antagonists |
| BR112016027778A2 (en) | 2014-05-30 | 2017-08-15 | Pfizer | USES OF CARBONITRIL DERIVATIVES, THEIR COMBINATION AND THEIR PHARMACEUTICAL COMPOSITION |
| ES2757074T3 (en) * | 2014-06-04 | 2020-04-28 | Monsanto Technology Llc | 3,6-Dichlorosalicylic Acid Compounds and Related Synthetic Procedures |
| SG11201805387RA (en) | 2015-12-30 | 2018-07-30 | Univ Saint Louis | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
| KR20230011967A (en) | 2020-05-14 | 2023-01-25 | 유비이 가부시키가이샤 | 1,4,5,6-tetrahydropyrimidin-2-amine derivatives |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO118289B1 (en) * | 1995-08-30 | 2003-04-30 | Gd Searle & Co Chicago | Phenyl carbonyl urea derivatives and pharmaceutical composition |
-
1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/en unknown
- 1999-02-22 EA EA200000804A patent/EA200000804A1/en unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/en unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/en active Pending
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Application Discontinuation
- 1999-02-22 UA UA2000095148A patent/UA71906C2/en unknown
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 IL IL13765399A patent/IL137653A0/en unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/en unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/en not_active Expired - Fee Related
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 YU YU52000A patent/YU52000A/en unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/en not_active Application Discontinuation
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/en unknown
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/en not_active Application Discontinuation
- 1999-02-22 ID IDW20001695A patent/ID25591A/en unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/en unknown
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/en unknown
- 1999-03-02 AR ARP990100880A patent/AR018139A1/en unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
-
2000
- 2000-08-04 IS IS5582A patent/IS5582A/en unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/en not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/en unknown
- 2000-09-01 HR HR20000574A patent/HRP20000574A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK13002000A3 (en) | 2001-07-10 |
| CA2322207A1 (en) | 1999-09-10 |
| BG104740A (en) | 2001-02-28 |
| WO1999044994A1 (en) | 1999-09-10 |
| NO315703B1 (en) | 2003-10-13 |
| GEP20033118B (en) | 2003-11-25 |
| UA71906C2 (en) | 2005-01-17 |
| YU52000A (en) | 2003-02-28 |
| AP1244A (en) | 2004-02-04 |
| ID25591A (en) | 2000-10-19 |
| EA200000804A1 (en) | 2001-04-23 |
| AU3294799A (en) | 1999-09-20 |
| OA11530A (en) | 2004-05-17 |
| CN1291978A (en) | 2001-04-18 |
| EE200000506A (en) | 2002-04-15 |
| KR20010041584A (en) | 2001-05-25 |
| TR200002542T2 (en) | 2001-05-21 |
| IS5582A (en) | 2000-08-04 |
| EP1060164A1 (en) | 2000-12-20 |
| PL342726A1 (en) | 2001-07-02 |
| NZ506598A (en) | 2003-07-25 |
| IL137653A0 (en) | 2001-10-31 |
| NO20004316D0 (en) | 2000-08-30 |
| HUP0100865A3 (en) | 2001-11-28 |
| AP2000001893A0 (en) | 2000-09-30 |
| NO20004316L (en) | 2000-11-06 |
| ZA994406B (en) | 2000-02-11 |
| CN1214011C (en) | 2005-08-10 |
| JP2002505323A (en) | 2002-02-19 |
| AU753230B2 (en) | 2002-10-10 |
| BR9908470A (en) | 2000-12-05 |
| AR018139A1 (en) | 2001-10-31 |
| MY123908A (en) | 2006-06-30 |
| HRP20000574A2 (en) | 2001-08-31 |
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