HUP0102887A2 - Lipidcsökkentő kinazolinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Lipidcsökkentő kinazolinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0102887A2 HUP0102887A2 HU0102887A HUP0102887A HUP0102887A2 HU P0102887 A2 HUP0102887 A2 HU P0102887A2 HU 0102887 A HU0102887 A HU 0102887A HU P0102887 A HUP0102887 A HU P0102887A HU P0102887 A2 HUP0102887 A2 HU P0102887A2
- Authority
- HU
- Hungary
- Prior art keywords
- lipid
- lowering
- pharmaceutical composition
- same
- composition containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- VWYAGHXULKUVQY-UHFFFAOYSA-N (3-bromophenyl)-(6,7-dimethoxyquinazolin-4-yl)methanone Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1C(=O)C1=CC=CC(Br)=C1 VWYAGHXULKUVQY-UHFFFAOYSA-N 0.000 abstract 1
- KHTZEFSHZJPOTJ-UHFFFAOYSA-N 1h-quinazolin-2-ylidenemethanone Chemical class C1=CC=C2C=NC(=C=O)NC2=C1 KHTZEFSHZJPOTJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 108010028554 LDL Cholesterol Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány új (I) általános képletű karbonil szubsztituáltkinazolinokra, előnyösen 4-(3'-bróm-benzoil)-6,7-dimetoxi-kinazolinra(WHI-P164) vonatkozik, és kiterjed a vegyület alkalmazására olyangyógyszer előállítására, amellyel a vér koleszterinszintjecsökkenthető, ideértve az össz-koleszterinszintet és az LDL-koleszterinszintet, melyet a karbonil-kinazolinok, illetve ezekettartalmazó készítmények adagolásával lehet elérni. Az (I) általánosképletben: X jelentése egyenes vagy elágazó láncú vagy ciklusosalkilcsoport vagy aromás gyűrűszerkezet, és R1-R5 egymástólfüggetlenül hidrogénatom, hidroxil-, NH2, SH, alkil-, alkoxi- vagyaciloxi-csoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/126,940 US6172071B1 (en) | 1998-07-30 | 1998-07-30 | Lipid-lowering quinazoline derivative |
| PCT/US1999/015841 WO2000006554A1 (en) | 1998-07-30 | 1999-07-13 | Lipid-lowering quinazoline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0102887A2 true HUP0102887A2 (hu) | 2003-02-28 |
Family
ID=22427479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102887A HUP0102887A2 (hu) | 1998-07-30 | 1999-07-13 | Lipidcsökkentő kinazolinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6172071B1 (hu) |
| EP (1) | EP1100787B1 (hu) |
| JP (1) | JP2002521475A (hu) |
| KR (1) | KR20010089146A (hu) |
| AT (1) | ATE306476T1 (hu) |
| AU (1) | AU750653B2 (hu) |
| CA (1) | CA2338825A1 (hu) |
| DE (1) | DE69927689T2 (hu) |
| HU (1) | HUP0102887A2 (hu) |
| IL (1) | IL141025A0 (hu) |
| MX (1) | MXPA01001139A (hu) |
| NO (1) | NO20010525L (hu) |
| WO (1) | WO2000006554A1 (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999010349A1 (en) | 1997-08-22 | 1999-03-04 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| US6410545B2 (en) | 1998-07-30 | 2002-06-25 | Parker Hughes Institute | Lipid lowering quinazoline dietary supplement composition |
| US6172071B1 (en) | 1998-07-30 | 2001-01-09 | Hughes Institute | Lipid-lowering quinazoline derivative |
| KR100838617B1 (ko) | 1999-02-10 | 2008-06-16 | 아스트라제네카 아베 | 혈관형성 억제제로서의 퀴나졸린 유도체 |
| US6126917A (en) * | 1999-06-01 | 2000-10-03 | Hadasit Medical Research Services And Development Ltd. | Epidermal growth factor receptor binding compounds for positron emission tomography |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CN101607958A (zh) | 2002-02-01 | 2009-12-23 | 阿斯特拉曾尼卡有限公司 | 喹唑啉化合物 |
| GB0330002D0 (en) | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
| WO2006034056A2 (en) * | 2004-09-16 | 2006-03-30 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| EP1827472A4 (en) * | 2004-12-06 | 2012-09-05 | Univ California | METHOD FOR IMPROVING THE STRUCTURE AND FUNCTION OF ARTERIOLS |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CN104016929B (zh) * | 2014-06-25 | 2016-03-30 | 北京理工大学 | 一种合成喹唑啉-4(3h)-酮的方法 |
| US20170233466A1 (en) * | 2016-02-17 | 2017-08-17 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Atherosclerosis by Administering an Inhibitor of ANGPTL3 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US6172071B1 (en) | 1998-07-30 | 2001-01-09 | Hughes Institute | Lipid-lowering quinazoline derivative |
-
1998
- 1998-07-30 US US09/126,940 patent/US6172071B1/en not_active Expired - Fee Related
-
1999
- 1999-07-13 AU AU49913/99A patent/AU750653B2/en not_active Ceased
- 1999-07-13 HU HU0102887A patent/HUP0102887A2/hu unknown
- 1999-07-13 KR KR1020017001293A patent/KR20010089146A/ko not_active Application Discontinuation
- 1999-07-13 WO PCT/US1999/015841 patent/WO2000006554A1/en active IP Right Grant
- 1999-07-13 DE DE69927689T patent/DE69927689T2/de not_active Expired - Fee Related
- 1999-07-13 AT AT99933976T patent/ATE306476T1/de not_active IP Right Cessation
- 1999-07-13 CA CA002338825A patent/CA2338825A1/en not_active Abandoned
- 1999-07-13 MX MXPA01001139A patent/MXPA01001139A/es unknown
- 1999-07-13 EP EP99933976A patent/EP1100787B1/en not_active Expired - Lifetime
- 1999-07-13 IL IL14102599A patent/IL141025A0/xx unknown
- 1999-07-13 JP JP2000562357A patent/JP2002521475A/ja active Pending
-
2001
- 2001-01-08 US US09/756,483 patent/US6355645B2/en not_active Expired - Fee Related
- 2001-01-30 NO NO20010525A patent/NO20010525L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01001139A (es) | 2002-04-24 |
| AU750653B2 (en) | 2002-07-25 |
| IL141025A0 (en) | 2002-02-10 |
| DE69927689D1 (de) | 2006-02-23 |
| DE69927689T2 (de) | 2006-07-20 |
| US6355645B2 (en) | 2002-03-12 |
| KR20010089146A (ko) | 2001-09-29 |
| EP1100787A1 (en) | 2001-05-23 |
| WO2000006554A1 (en) | 2000-02-10 |
| EP1100787B1 (en) | 2005-10-12 |
| AU4991399A (en) | 2000-02-21 |
| JP2002521475A (ja) | 2002-07-16 |
| US6172071B1 (en) | 2001-01-09 |
| US20010008894A1 (en) | 2001-07-19 |
| NO20010525D0 (no) | 2001-01-30 |
| CA2338825A1 (en) | 2000-02-10 |
| ATE306476T1 (de) | 2005-10-15 |
| NO20010525L (no) | 2001-01-30 |
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